The LRRK2 inhibitor GSK2578215A induces protective autophagy in SH-SY5Y cells: involvement of Drp-1-mediated mitochondrial fission and mitochondrial-derived ROS signaling. (Q35679501)

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scientific article published on 14 August 2014

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English	The LRRK2 inhibitor GSK2578215A induces protective autophagy in SH-SY5Y cells: involvement of Drp-1-mediated mitochondrial fission and mitochondrial-derived ROS signaling.	scientific article published on 14 August 2014

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12 March 2020

The LRRK2 inhibitor GSK2578215A induces protective autophagy in SH-SY5Y cells: involvement of Drp-1-mediated mitochondrial fission and mitochondrial-derived ROS signaling (English)

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12 March 2020

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mitochondrial fission

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José Rafael Blesa

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12 March 2020

Michael P. Murphy

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12 March 2020

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S Saez-Atienzar

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L Bonet-Ponce

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F J Romero

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M F Galindo

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14 August 2014

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Cell Death and Disease

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e1368

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Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported

1 August 2014

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Mutant LRRK2 toxicity in neurons depends on LRRK2 levels and synuclein but not kinase activity or inclusion bodies

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Functional interaction of Parkinson's disease-associated LRRK2 with members of the dynamin GTPase superfamily

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Physiological and pathological significance of dynamin-related protein 1 (drp1)-dependent mitochondrial fission in the nervous system

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Interplay of LRRK2 with chaperone-mediated autophagy

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LRRK2 interactions with α-synuclein in Parkinson's disease brains and in cell models

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12 July 2018

GSK2578215A; a potent and highly selective 2-arylmethyloxy-5-substitutent-N-arylbenzamide LRRK2 kinase inhibitor

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The mitochondria-targeted anti-oxidant MitoQ reduces aspects of mitochondrial fission in the 6-OHDA cell model of Parkinson's disease.

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LRRK2 regulates mitochondrial dynamics and function through direct interaction with DLP1

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12 July 2018

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Autophagy and disease: always two sides to a problem

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Genetic characteristics of leucine-rich repeat kinase 2 (LRRK2) associated Parkinson's disease

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12 July 2018

A QUICK screen for Lrrk2 interaction partners--leucine-rich repeat kinase 2 is involved in actin cytoskeleton dynamics.

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12 July 2018

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12 July 2018

Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of alpha-synuclein, and apoptotic cell death in aged mice

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12 July 2018

Leucine-rich repeat kinase 2 regulates the progression of neuropathology induced by Parkinson's-disease-related mutant alpha-synuclein.

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12 July 2018

alpha-synuclein and LRRK2: partners in crime

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12 July 2018

Phosphorylation of ezrin/radixin/moesin proteins by LRRK2 promotes the rearrangement of actin cytoskeleton in neuronal morphogenesis

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S-nitrosylation of Drp1 mediates beta-amyloid-related mitochondrial fission and neuronal injury

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LRRK2 exon 41 mutations in sporadic Parkinson disease in Europeans

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Microtubule dynamics

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12 December 2020

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10.1038/CDDIS.2014.320

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12 March 2020

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