Emerging roles for hyaluronidase in cancer metastasis and therapy (Q35653691)

9 August 2017

title

Emerging roles for hyaluronidase in cancer metastasis and therapy (English)

1 reference

9 August 2017

1 reference

Caitlin O McAtee

1

1 reference

9 August 2017

Joseph J Barycki

series ordinal

2

1 reference

9 August 2017

Melanie A Simpson

series ordinal

3

1 reference

9 August 2017

publication date

1 January 2014

1 reference

Advances in Cancer Research

9 August 2017

published in

1 reference

9 August 2017

volume

123

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9 August 2017

page(s)

1-34

1 reference

Hyaluronidases Have Strong Hydrolytic Activity toward Chondroitin 4-Sulfate Comparable to that for Hyaluronan.

9 August 2017

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High-molecular-mass hyaluronan mediates the cancer resistance of the naked mole rat.

12 July 2018

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Hyaluronan production enhances shedding of plasma membrane-derived microvesicles

12 July 2018

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Inverse expression of hyaluronidase 2 and hyaluronan synthases 1-3 is associated with reduced hyaluronan content in malignant cutaneous melanoma

12 July 2018

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Molecular mechanisms and imaging of lymphatic metastasis

12 July 2018

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12 July 2018

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FRET based ratio-metric sensing of hyaluronidase in synthetic urine as a biomarker for bladder and prostate cancer.

12 July 2018

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Role of the extracellular matrix in variations of invasive pathways in lung cancers.

12 July 2018

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The high and low molecular weight forms of hyaluronan have distinct effects on CD44 clustering

12 July 2018

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Identification of amino acid residues required for the substrate specificity of human and mouse chondroitin sulfate hydrolase (conventional hyaluronidase-4)

12 July 2018

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Dual-functional liposomes based on pH-responsive cell-penetrating peptide and hyaluronic acid for tumor-targeted anticancer drug delivery

12 July 2018

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Detection of hyaluronidase activity using fluorescein labeled hyaluronic acid and Fluorescence Correlation Spectroscopy

12 July 2018

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Indocyanine green encapsulated nanogels for hyaluronidase activatable and selective near infrared imaging of tumors and lymph nodes

12 July 2018

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Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma

12 July 2018

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Peripheral blood DNA methylation profiles are indicative of head and neck squamous cell carcinoma: an epigenome-wide association study

12 July 2018

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12 July 2018

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Therapeutic potential of hyaluronan oligosaccharides for bone metastasis of breast cancer

12 July 2018

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Molecular characterization of kidney cancer: association of hyaluronic acid family with histological subtypes and metastasis

12 July 2018

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Upregulation of HYAL1 expression in breast cancer promoted tumor cell proliferation, migration, invasion and angiogenesis

12 July 2018

1 reference

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Fragmented hyaluronan is an autocrine chemokinetic motility factor supported by the HAS2-HYAL2/CD44 system on the plasma membrane

12 July 2018

1 reference

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Hyal2 is a glycosylphosphatidylinositol-anchored, lipid raft-associated hyaluronidase

12 July 2018

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Subtype specific elevated expression of hyaluronidase-1 (HYAL-1) in epithelial ovarian cancer

12 July 2018

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Targeting hyaluronidase for cancer therapy: antitumor activity of sulfated hyaluronic acid in prostate cancer cells

12 July 2018

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Hyaluronan suppresses prostate tumor cell proliferation through diminished expression of N-cadherin and aberrant growth factor receptor signaling.

12 July 2018

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Cancer exosomes trigger fibroblast to myofibroblast differentiation

12 July 2018

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Association of hyaluronic acid family members (HAS1, HAS2, and HYAL‐1) with bladder cancer diagnosis and prognosis

12 July 2018

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Hyaluronan synthases (HAS1-3) and hyaluronidases (HYAL1-2) in the accumulation of hyaluronan in endometrioid endometrial carcinoma

12 July 2018

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Involvement of hyaluronidases in colorectal cancer

12 July 2018

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Nodular basal cell carcinoma is associated with increased hyaluronan homeostasis

12 July 2018

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Signaling from membrane receptors to tumor suppressor WW domain-containing oxidoreductase

12 July 2018

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HYAL1 overexpression is correlated with the malignant behavior of human breast cancer

12 July 2018

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Hyaluronan stabilizes focal adhesions, filopodia, and the proliferative phenotype in esophageal squamous carcinoma cells.

12 July 2018

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Two novel functions of hyaluronidase-2 (Hyal2) are formation of the glycocalyx and control of CD44-ERM interactions

12 July 2018

1 reference

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Hyaluronic acid and HYAL-1 in prostate biopsy specimens: predictors of biochemical recurrence

12 July 2018

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bFGF induces changes in hyaluronan synthase and hyaluronidase isoform expression and modulates the migration capacity of fibrosarcoma cells

12 July 2018

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Designed human serum hyaluronidase 1 variant, HYAL1DeltaL, exhibits activity up to pH 5.9

12 July 2018

1 reference

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Size-dependent regulation of Snail2 by hyaluronan: its role in cellular invasion

12 July 2018

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Expression of hyaluronan synthases (HAS1-3) and hyaluronidases (HYAL1-2) in serous ovarian carcinomas: inverse correlation between HYAL1 and hyaluronan content

12 July 2018

1 reference

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Transforming growth factor beta1 signaling via interaction with cell surface Hyal-2 and recruitment of WWOX/WOX1

12 July 2018

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HYAL-1 hyaluronidase: a potential prognostic indicator for progression to muscle invasion and recurrence in bladder cancer

12 July 2018

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Protein structure prediction on the Web: a case study using the Phyre server

12 July 2018

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Spontaneous metastasis of prostate cancer is promoted by excess hyaluronan synthesis and processing

12 July 2018

1 reference

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Hyaluronidase activity of human Hyal1 requires active site acidic and tyrosine residues

12 July 2018

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Cancer-associated splicing variants of the CDCA1 and MSMB genes expressed in cancer cell lines and surgically resected gastric cancer tissues.

12 July 2018

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Chondroitin sulfate E fragments enhance CD44 cleavage and CD44-dependent motility in tumor cells

12 July 2018

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Molecular risk assessment for breast cancer development in patients with ductal hyperplasias

12 July 2018

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Mouse Hyal3 encodes a 45- to 56-kDa glycoprotein whose overexpression increases hyaluronidase 1 activity in cultured cells

12 July 2018

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Structure of human hyaluronidase-1, a hyaluronan hydrolyzing enzyme involved in tumor growth and angiogenesis

12 July 2018

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Inducible hyaluronan production reveals differential effects on prostate tumor cell growth and tumor angiogenesis

12 July 2018

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Recombinant human hyaluronidase Hyal-1: insect cells versus Escherichia coli as expression system and identification of low molecular weight inhibitors

12 July 2018

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Kinetic analysis of hyaluronidase activity using a bioactive MRI contrast agent

12 July 2018

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CD44-dependent intracellular and extracellular catabolism of hyaluronic acid by hyaluronidase-1 and -2

12 July 2018

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HYAL1-v1, an alternatively spliced variant of HYAL1 hyaluronidase: a negative regulator of bladder cancer

12 July 2018

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Hyaluronidase expression induces prostate tumor metastasis in an orthotopic mouse model

12 July 2018

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Concurrent expression of hyaluronan biosynthetic and processing enzymes promotes growth and vascularization of prostate tumors in mice

12 July 2018

1 reference

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Amino acid residues that are important for Hyal2 function as a receptor for jaagsiekte sheep retrovirus

12 July 2018

1 reference

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Differential selectivity of hyaluronidase inhibitors toward acidic and basic hyaluronidases

12 July 2018

1 reference

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HYAL1 hyaluronidase in prostate cancer: a tumor promoter and suppressor

12 July 2018

1 reference

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The over-expression of HAS2, Hyal-2 and CD44 is implicated in the invasiveness of breast cancer

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4445717

Expression and characterization of a soluble, active form of the jaagsiekte sheep retrovirus receptor, Hyal2.

12 July 2018

1 reference

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Inhibition of hyaluronan degradation by dextran sulphate facilitates characterisation of hyaluronan synthesis: an in vitro and in vivo study

12 July 2018

1 reference

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Comparison of the prognostic potential of hyaluronic acid, hyaluronidase (HYAL-1), CD44v6 and microvessel density for prostate cancer

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4445717

Expression of WW domain-containing oxidoreductase WOX1 in the developing murine nervous system

12 July 2018

1 reference

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Selective expression and functional characteristics of three mammalian hyaluronan synthases in oncogenic malignant transformation.

12 July 2018

1 reference

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Evaluation of the prognostic potential of hyaluronic acid and hyaluronidase (HYAL1) for prostate cancer

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4445717

Hyaluronidase 2 negatively regulates RON receptor tyrosine kinase and mediates transformation of epithelial cells by jaagsiekte sheep retrovirus

12 July 2018

1 reference

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Role of virus receptor Hyal2 in oncogenic transformation of rodent fibroblasts by sheep betaretrovirus env proteins

12 July 2018

1 reference

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Expression of hyaluronan synthase 2 or hyaluronidase 1 differentially affect the growth rate of transplantable colon carcinoma cell tumors

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4445717

Inhibition of prostate tumor cell hyaluronan synthesis impairs subcutaneous growth and vascularization in immunocompromised mice

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4445717

Regulation of hyaluronidase activity by alternative mRNA splicing

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4445717

Overexpression of hyaluronan synthase-2 reduces the tumorigenic potential of glioma cells lacking hyaluronidase activity.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4445717

Transforming growth factor-beta1 blocks the enhancement of tumor necrosis factor cytotoxicity by hyaluronidase Hyal-2 in L929 fibroblasts

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4445717

The six hyaluronidase-like genes in the human and mouse genomes

12 July 2018

1 reference

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Hyaluronan enters keratinocytes by a novel endocytic route for catabolism

12 July 2018

1 reference

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Disruption of hyaluronan synthase-2 abrogates normal cardiac morphogenesis and hyaluronan-mediated transformation of epithelium to mesenchyme

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4445717

CD44 interaction with tiam1 promotes Rac1 signaling and hyaluronic acid-mediated breast tumor cell migration

12 July 2018

1 reference

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Three isoforms of mammalian hyaluronan synthases have distinct enzymatic properties

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4445717

Association of hyaluronidase and breast adenocarcinoma invasiveness.

12 July 2018

1 reference

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Overproduction of hyaluronan by expression of the hyaluronan synthase Has2 enhances anchorage-independent growth and tumorigenicity.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4445717

HYAL2, a human gene expressed in many cells, encodes a lysosomal hyaluronidase with a novel type of specificity

12 July 2018

1 reference

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Inhibition of tumor growth in vivo by hyaluronan oligomers

12 July 2018

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Hyaluronan: its nature, distribution, functions and turnover

12 July 2018

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Early-response gene signalling is induced by angiogenic oligosaccharides of hyaluronan in endothelial cells. Inhibition by non-angiogenic, high-molecular-weight hyaluronan.

12 July 2018

1 reference

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The structure and function of hyaluronan: An overview

12 July 2018

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The role of hyaluronan in tumour neovascularization (review).

12 July 2018

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Angiogenesis induced by degradation products of hyaluronic acid.

12 July 2018

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CD44 is the principal cell surface receptor for hyaluronate

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4445717

Analysis of HYAL3 gene mutations in Chinese lung squamous cell carcinoma patients.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4445717

Detection of hyaluronidase RNA and activity in urine of schistosomal and non-schistosomal bladder cancer.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4445717

Hyaluronidase splice variants are associated with histology and outcome in adenocarcinoma and squamous cell carcinoma of the lung.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4445717

Autodisplay of catalytically active human hyaluronidase hPH-20 and testing of enzyme inhibitors

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4445717

Investigation of aminomethyl indole derivatives as hyaluronidase inhibitors.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4445717

Expression of HYAL1 and survivin RNA as diagnostic molecular markers for bladder cancer.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4445717

Identification of human hyaluronidase-4 as a novel chondroitin sulfate hydrolase that preferentially cleaves the galactosaminidic linkage in the trisulfated tetrasaccharide sequence.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4445717

Hyaluronidase 3 (HYAL3) knockout mice do not display evidence of hyaluronan accumulation.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4445717

New potent indole derivatives as hyaluronidase inhibitors

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4445717

Quantitative imaging of lymph function

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4445717

Magnetic resonance imaging visualization of hyaluronidase in ovarian carcinoma

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4445717

L-Ascorbic acid 6-hexadecanoate, a potent hyaluronidase inhibitor. X-ray structure and molecular modeling of enzyme-inhibitor complexes

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4445717

Strong Stromal Hyaluronan Expression Is Associated with PSA Recurrence in Local Prostate Cancer

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4445717

A novel PKC-regulated mechanism controls CD44 ezrin association and directional cell motility

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4445717

Expression of PH-20 in normal and neoplastic breast tissue.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4445717

Hyaluronidase gene profiling and role of hyal-1 overexpression in an orthotopic model of prostate cancer.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4445717

Hyaluronidase-2 overexpression accelerates intracerebral but not subcutaneous tumor formation of murine astrocytoma cells.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4445717

Increased hyaluronidase expression in more aggressive prostate adenocarcinoma.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4445717

Genetic deletions in sputum as diagnostic markers for early detection of stage I non-small cell lung cancer

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4445717

Urinary retinoic acid receptor-β2 gene promoter methylation and hyaluronidase activity as noninvasive tests for diagnosis of bladder cancer

15 November 2018

1 reference

12 December 2020

PH20: a novel tumor marker for laryngeal cancer

1 reference

12 December 2020

Hyaluronated nanoparticles with pH- and enzyme-responsive drug release properties

1 reference

12 December 2020

The effect of hyaluronate and its oligosaccharides on endothelial cell proliferation and monolayer integrity

1 reference

12 December 2020

Isoforms of hyaluronidases can be a predictor of a prostate cancer of good prognosis

1 reference

12 December 2020

Hyaluronidases and their inhibitors in the serum of colorectal carcinoma patients

1 reference

12 December 2020

Inhibition of hyaluronidase by fully O-sulfonated glycosaminoglycans

1 reference

12 December 2020

Hyaluronan in morphogenesis

1 reference

12 December 2020

Stromal and epithelial expression of tumor markers hyaluronic acid and HYAL1 hyaluronidase in prostate cancer

1 reference

12 December 2020

10.1016/B978-0-12-800092-2.00001-0

Identifiers

DOI

1 reference

9 August 2017

1 reference

9 August 2017

1 reference