Combined blockade of integrin-α4β1 plus cytokines SDF-1α or IL-1β potently inhibits tumor inflammation and growth (Q35645125)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21948958 AND SRC:MED&resulttype=core&format=json

13 February 2020

title

Combined blockade of integrin-α4β1 plus cytokines SDF-1α or IL-1β potently inhibits tumor inflammation and growth (English)

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13 February 2020

1

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13 February 2020

Judith A. Varner

7

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13 February 2020

author name string

Christie J Avraamides

2

1 reference

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13 February 2020

Philippe Foubert

3

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13 February 2020

Yuval Shaked

4

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13 February 2020

Sang Won Kang

5

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13 February 2020

Robert S Kerbel

6

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13 February 2020

language of work or name

English

0 references

publication date

23 September 2011

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13 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21948958 AND SRC:MED&resulttype=core&format=json

13 February 2020

volume

71

1 reference

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13 February 2020

issue

22

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13 February 2020

page(s)

6965-6975

1 reference

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Receptor tyrosine kinases and TLR/IL1Rs unexpectedly activate myeloid cell PI3kγ, a single convergent point promoting tumor inflammation and progression.

13 February 2020

cites work

1 reference

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Proliferating macrophages associated with high grade, hormone receptor negative breast cancer and poor clinical outcome

12 July 2018

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Interleukin-1β regulates the migratory potential of MDAMB231 breast cancer cells through the hypoxia-inducible factor-1α.

12 July 2018

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12 July 2018

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Proinflammatory cytokines in breast cancer: mechanisms of action and potential targets for therapeutics

12 July 2018

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Role of myeloid cells in vascular endothelial growth factor-independent tumor angiogenesis

12 July 2018

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Immunity, Inflammation, and Cancer

12 July 2018

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Effects of IL-1 molecules on growth patterns of 3-MCA-induced cell lines: an interplay between immunogenicity and invasive potential

12 July 2018

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Myeloid-derived suppressor cells: linking inflammation and cancer

12 July 2018

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Rapid chemotherapy-induced acute endothelial progenitor cell mobilization: implications for antiangiogenic drugs as chemosensitizing agents

12 July 2018

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Tumor escape mechanism governed by myeloid-derived suppressor cells

12 July 2018

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Is interleukin-1 a good or bad 'guy' in tumor immunobiology and immunotherapy?

12 July 2018

1 reference

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HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249446

Matrix metalloproteinase-9 is required for tumor vasculogenesis but not for angiogenesis: role of bone marrow-derived myelomonocytic cells

12 July 2018

1 reference

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Plasticity of macrophage function during tumor progression: regulation by distinct molecular mechanisms

12 July 2018

1 reference

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Reduced inflammation in the tumor microenvironment delays the accumulation of myeloid-derived suppressor cells and limits tumor progression

12 July 2018

1 reference

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Tumor refractoriness to anti-VEGF treatment is mediated by CD11b Gr1 myeloid cells.

12 July 2018

1 reference

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Macrophages regulate the angiogenic switch in a mouse model of breast cancer

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249446

The involvement of IL-1 in tumorigenesis, tumor invasiveness, metastasis and tumor-host interactions

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249446

Therapy-induced acute recruitment of circulating endothelial progenitor cells to tumors.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249446

Blocking the alpha 4 integrin-paxillin interaction selectively impairs mononuclear leukocyte recruitment to an inflammatory site

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249446

Alpha4beta1-dependent adhesion strengthening under mechanical strain is regulated by paxillin association with the alpha4-cytoplasmic domain

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249446

Chemokines direct endothelial progenitors into tumor neovessels

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249446

Integrin structure, allostery, and bidirectional signaling

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249446

Macrophages direct tumour histology and clinical outcome in a colon cancer model

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249446

Macrophages promote the invasion of breast carcinoma cells via a colony-stimulating factor-1/epidermal growth factor paracrine loop

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249446

Transforming growth factor-beta production and myeloid cells are an effector mechanism through which CD1d-restricted T cells block cytotoxic T lymphocyte-mediated tumor immunosurveillance: abrogation prevents tumor recurrence.

12 July 2018

1 reference

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Progression to Malignancy in the Polyoma Middle T Oncoprotein Mouse Breast Cancer Model Provides a Reliable Model for Human Diseases

12 July 2018

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12 July 2018

Inflammation and cancer

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Alpha4 integrins and the immune response

12 July 2018

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Contributions of stromal metalloproteinase-9 to angiogenesis and growth of human ovarian carcinoma in mice

12 July 2018

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Subsecond induction of alpha4 integrin clustering by immobilized chemokines stimulates leukocyte tethering and rolling on endothelial vascular cell adhesion molecule 1 under flow conditions

12 July 2018

1 reference

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Activated conformations of very late activation integrins detected by a group of antibodies (HUTS) specific for a novel regulatory region (355-425) of the common beta 1 chain

12 July 2018

1 reference

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Urokinase and macrophages in tumour angiogenesis

12 July 2018

1 reference

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A homing mechanism for bone marrow-derived progenitor cell recruitment to the neovasculature

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249446

Integrin alpha4beta1 promotes monocyte trafficking and angiogenesis in tumors.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3249446

Expansion of myeloid immune suppressor Gr CD11b cells in tumor-bearing host directly promotes tumor angiogenesis

25 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21948958

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Significance of macrophage chemoattractant protein-1 in macrophage recruitment, angiogenesis, and survival in human breast cancer

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21948958

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1158/0008-5472.CAN-11-0588

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21948958 AND SRC:MED&resulttype=core&format=json

13 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21948958 AND SRC:MED&resulttype=core&format=json

13 February 2020

PubMed publication ID

21948958

1 reference