FOXO3a-Dependent Mechanism of E1A-Induced Chemosensitization (Q35622770)

9 August 2017

title

FOXO3a-Dependent Mechanism of E1A-Induced Chemosensitization (English)

1 reference

9 August 2017

Kuo-Tai Hua

8

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Dung-Fang Lee

Dung-Fang Lee

6

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Michael Hsiao

Michael Hsiao

10

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Robert C. Bast

Robert C Bast

13

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Gabriel N Hortobagyi

14

Gabriel N Hortobagyi

1 reference

9 August 2017

15

Mien-Chie Hung

1 reference

9 August 2017

3

Hirohito Yamaguchi

1 reference

9 August 2017

7

How-Wen Ko

1 reference

9 August 2017

11

Poshen B Chen

1 reference

9 August 2017

9

Ying-Nai Wang

1 reference

9 August 2017

12

Jung-Mao Hsu

1 reference

9 August 2017

Jen-Liang Su

1

1 reference

9 August 2017

Xiaoyun Cheng

2

1 reference

9 August 2017

Yi-Wen Chang

4

1 reference

9 August 2017

Chao-Feng Hou

5

1 reference

9 August 2017

language of work or name

English

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publication date

12 September 2011

1 reference

9 August 2017

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9 August 2017

volume

71

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9 August 2017

issue

21

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9 August 2017

page(s)

6878-6887

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Inhibition of FOXO3 tumor suppressor function by betaTrCP1 through ubiquitin-mediated degradation in a tumor mouse model

9 August 2017

cites work

1 reference

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Protein phosphatase 2A is a negative regulator of transforming growth factor-beta1-induced TAK1 activation in mesangial cells

12 July 2018

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ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation

12 July 2018

1 reference

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Novel approaches for chemosensitization of breast cancer cells: the E1A story

12 July 2018

1 reference

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IKK beta suppression of TSC1 links inflammation and tumor angiogenesis via the mTOR pathway

12 July 2018

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CIP2A inhibits PP2A in human malignancies

12 July 2018

1 reference

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PP2A: unveiling a reluctant tumor suppressor

12 July 2018

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The tumor suppressor PP2A Abeta regulates the RalA GTPase

12 July 2018

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Involvement of PP2A in viral and cellular transformation

12 July 2018

1 reference

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The tumor suppressor PP2A is functionally inactivated in blast crisis CML through the inhibitory activity of the BCR/ABL-regulated SET protein

12 July 2018

1 reference

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TAK1 is recruited to the tumor necrosis factor-alpha (TNF-alpha) receptor 1 complex in a receptor-interacting protein (RIP)-dependent manner and cooperates with MEKK3 leading to NF-kappaB activation

12 July 2018

1 reference

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Adenoviral E1A targets Mdm4 to stabilize tumor suppressor p53

12 July 2018

1 reference

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A new role of protein phosphatase 2a in adenoviral E1A protein-mediated sensitization to anticancer drug-induced apoptosis in human breast cancer cells

12 July 2018

1 reference

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Enhanced paclitaxel cytotoxicity and prolonged animal survival rate by a nonviral-mediated systemic delivery of E1A gene in orthotopic xenograft human breast cancer

12 July 2018

1 reference

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FoxOs at the crossroads of cellular metabolism, differentiation, and transformation

12 July 2018

1 reference

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IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242367

The many faces of beta-TrCP E3 ubiquitin ligases: reflections in the magic mirror of cancer

12 July 2018

1 reference

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Adenovirus type 5 E1A sensitizes hepatocellular carcinoma cells to gemcitabine

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242367

FoxO3a transcriptional regulation of Bim controls apoptosis in paclitaxel-treated breast cancer cell lines

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242367

Regulation of the activity of p38 mitogen-activated protein kinase by Akt in cancer and adenoviral protein E1A-mediated sensitization to apoptosis

12 July 2018

1 reference

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Cell cycle inhibition by FoxO forkhead transcription factors involves downregulation of cyclin D.

12 July 2018

1 reference

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Adenovirus-5 E1A: paradox and paradigm

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242367

TAK1 is a ubiquitin-dependent kinase of MKK and IKK

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242367

Role of serine/threonine protein phosphatase 2A in cancer

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242367

Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242367

Development of clinical trial of E1A gene therapy targeting HER-2/neu-overexpressing breast and ovarian cancer

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242367

AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242367

E1A is sufficient by itself to induce apoptosis independent of p53 and other adenoviral gene products.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242367

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242367

The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242367

Adenovirus E1A expression enhances the sensitivity of an ovarian cancer cell line to multiple cytotoxic agents through an apoptotic mechanism

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242367

E1A signaling to p53 involves the p19(ARF) tumor suppressor

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242367

Chemosensitization of HER-2/neu-overexpressing human breast cancer cells to paclitaxel (Taxol) by adenovirus type 5 E1A

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242367

bax-deficiency promotes drug resistance and oncogenic transformation by attenuating p53-dependent apoptosis

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242367

RIP mediates tumor necrosis factor receptor 1 activation of NF-kappaB but not Fas/APO-1-initiated apoptosis

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242367

Enhanced c-erbB-2/neu expression in human ovarian cancer cells correlates with more severe malignancy that can be suppressed by E1A.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242367

Adenovirus E1a-mediated tumor suppression by a c-erbB-2/neu-independent mechanism

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242367

Mechanisms of c-erbB2/neu oncogene-induced metastasis and repression of metastatic properties by adenovirus 5 E1A gene products

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242367

Critical roles of threonine 187 phosphorylation in cellular stress-induced rapid and transient activation of transforming growth factor-beta-activated kinase 1 (TAK1) in a signaling complex containing TAK1-binding protein TAB1 and TAB2.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242367

FOXO transcription factors directly activate bim gene expression and promote apoptosis in sympathetic neurons

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242367

A multicenter phase II study of tgDCC-E1A for the intratumoral treatment of patients with recurrent head and neck squamous cell carcinoma

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242367

E1A: tumor suppressor or oncogene? Preclinical and clinical investigations of E1A gene therapy

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242367

Phase I trial of intratumoral liposome E1A gene therapy in patients with recurrent breast and head and neck cancer

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242367

E1A-mediated paclitaxel sensitization in HER-2/neu-overexpressing ovarian cancer SKOV3.ip1 through apoptosis involving the caspase-3 pathway.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242367

Adenovirus 5 E1A-mediated tumor suppression associated with E1A-mediated apoptosis in vivo.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242367

A Phase I multicenter study of E1A gene therapy for patients with metastatic breast cancer and epithelial ovarian cancer that overexpresses HER-2/neu or epithelial ovarian cancer

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242367

The erbB2 gene as a cancer therapeutic target and the tumor- and metastasis-suppressing function of E1A

25 September 2018

1 reference

12 December 2020

E1A sensitizes cells to tumor necrosis factor-induced apoptosis through inhibition of IkappaB kinases and nuclear factor kappaB activities

1 reference

12 December 2020

Primary cells suppress oncogene-dependent apoptosis

1 reference

12 December 2020

Adenovirus E1A proteins induce apoptosis by both p53-dependent and p53-independent mechanisms

1 reference

12 December 2020

10.1158/0008-5472.CAN-11-0295

Identifiers

DOI

1 reference

9 August 2017

1 reference

9 August 2017

1 reference