SHP-2 phosphatase is required for hematopoietic cell transformation by Bcr-Abl (Q35615838)

9 August 2017

title

SHP-2 phosphatase is required for hematopoietic cell transformation by Bcr-Abl (English)

1 reference

9 August 2017

Brian J Druker

5

0 references

Hal E. Broxmeyer

4

object named as

Hal E Broxmeyer

1 reference

9 August 2017

Jing Chen

1

1 reference

9 August 2017

Wen-Mei Yu

2

1 reference

9 August 2017

Hanako Daino

3

1 reference

9 August 2017

Cheng-Kui Qu

6

1 reference

9 August 2017

language of work or name

English

0 references

publication date

26 September 2006

1 reference

9 August 2017

number of pages

8

1 reference

based on heuristic

inferred from page(s)

published in

Blood

1 reference

9 August 2017

volume

109

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9 August 2017

issue

2

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9 August 2017

page(s)

778-785

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Functional analysis of leukemia-associated PTPN11 mutations in primary hematopoietic cells

9 August 2017

cites work

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Human somatic PTPN11 mutations induce hematopoietic-cell hypersensitivity to granulocyte-macrophage colony-stimulating factor

12 July 2018

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Catalytic-dependent and -independent roles of SHP-2 tyrosine phosphatase in interleukin-3 signaling

12 July 2018

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DNA damage-induced G2/M checkpoint in SV40 large T antigen-immortalized embryonic fibroblast cells requires SHP-2 tyrosine phosphatase

12 July 2018

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Critical role for Gab2 in transformation by BCR/ABL

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12 July 2018

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Requirement of Shp-2 tyrosine phosphatase in lymphoid and hematopoietic cell development

12 July 2018

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The NH(2)-terminal coiled-coil domain and tyrosine 177 play important roles in induction of a myeloproliferative disease in mice by Bcr-Abl

12 July 2018

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The heat shock protein 90 antagonist geldanamycin alters chaperone association with p210bcr-abl and v-src proteins before their degradation by the proteasome

12 July 2018

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The Grb2 binding site is required for the induction of chronic myeloid leukemia-like disease in mice by the Bcr/Abl tyrosine kinase

12 July 2018

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Molecular mechanism for the Shp-2 tyrosine phosphatase function in promoting growth factor stimulation of Erk activity

12 July 2018

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Enforced expression of the GATA-2 transcription factor blocks normal hematopoiesis.

12 July 2018

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Biased suppression of hematopoiesis and multiple developmental defects in chimeric mice containing Shp-2 mutant cells

12 July 2018

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Protein-tyrosine phosphatase Shp-2 regulates cell spreading, migration, and focal adhesion

12 July 2018

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The phosphatidylinositol polyphosphate 5-phosphatase SHIP and the protein tyrosine phosphatase SHP-2 form a complex in hematopoietic cells which can be regulated by BCR/ABL and growth factors

12 July 2018

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A deletion mutation in the SH2-N domain of Shp-2 severely suppresses hematopoietic cell development

12 July 2018

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Src homology 2 protein tyrosine phosphatase (SHPTP2)/Src homology 2 phosphatase 2 (SHP2) tyrosine phosphatase is a positive regulator of the interleukin 5 receptor signal transduction pathways leading to the prolongation of eosinophil survival

12 July 2018

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BCR/ABL induces multiple abnormalities of cytoskeletal function

12 July 2018

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In vivo repopulating hematopoietic stem cells are present in the murine yolk sac at day 9.0 postcoitus

12 July 2018

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12 July 2018

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Role for c-Abl tyrosine kinase in growth arrest response to DNA damage.

12 July 2018

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Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells

12 July 2018

1 reference

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Efficient transplantation of BCR-ABL-induced chronic myelogenous leukemia-like syndrome in mice

12 July 2018

1 reference

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SH2-containing phosphotyrosine phosphatase Syp is a target of p210bcr-abl tyrosine kinase.

12 July 2018

1 reference

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Activation of the c-Abl tyrosine kinase in the stress response to DMA-damaging agents

12 July 2018

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Letter: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining

12 July 2018

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In vitro transformation of immature hematopoietic cells by the P210 BCR/ABL oncogene product of the Philadelphia chromosome

12 July 2018

1 reference

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The chronic myelogenous leukemia-specific P210 protein is the product of the bcr/abl hybrid gene

12 July 2018

1 reference

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Induction of chronic myelogenous leukemia in mice by the P210bcr/abl gene of the Philadelphia chromosome

12 July 2018

1 reference

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Effects of a leukemia-associated gain-of-function mutation of SHP-2 phosphatase on interleukin-3 signaling

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1785089

SHP-2 phosphatase regulates DNA damage-induced apoptosis and G2/M arrest in catalytically dependent and independent manners, respectively

25 September 2018

1 reference

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Prognostic, therapeutic, and mechanistic implications of a mouse model of leukemia evoked by Shp2 (PTPN11) mutations.

25 September 2018

1 reference

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A negative role of SHP-2 tyrosine phosphatase in growth factor-dependent hematopoietic cell survival

25 September 2018

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c-CBL is not required for leukemia induction by Bcr-Abl in mice

25 September 2018

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Mutations in PTPN11 implicate the SHP-2 phosphatase in leukemogenesis

25 September 2018

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Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1785089

The coiled-coil domain and Tyr177 of bcr are required to induce a murine chronic myelogenous leukemia-like disease by bcr/abl.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1785089

Geldanamycin and its analogue 17-allylamino-17-demethoxygeldanamycin lowers Bcr-Abl levels and induces apoptosis and differentiation of Bcr-Abl-positive human leukemic blasts

25 September 2018

1 reference

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Characterization of two SHP-2-associated binding proteins and potential substrates in hematopoietic cells.

25 September 2018

1 reference

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Reduced incidence of persistent chromosome aberrations in mice irradiated at low dose rates

25 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17003374

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Initiation of deregulated growth of multipotent progenitor cells by bcr-abl in vitro

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17003374

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1182/BLOOD-2006-04-019141

1 reference

9 August 2017

1 reference

9 August 2017

1 reference