Pyroglutamate Amyloid-β (Aβ): A Hatchet Man in Alzheimer Disease (Q35604177)

9 August 2017

1 reference

title

Pyroglutamate amyloid-β (Aβ): a hatchet man in Alzheimer disease (English)

1 reference

9 August 2017

Pyroglutamate Amyloid-β (Aβ): A Hatchet Man in Alzheimer Disease (English)

1 reference

https://api.crossref.org/works/10.1074/JBC.R111.288308

13 December 2024

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2

Oliver Wirths

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:21965666

13 December 2024

author name string

Sadim Jawhar

series ordinal

1

1 reference

9 August 2017

Thomas A. Bayer

series ordinal

3

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:21965666

13 December 2024

language of work or name

English

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publication date

29 September 2011

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9 August 2017

number of pages

8

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full work available at URL

inferred from page(s)

https://europepmc.org/articles/pmc3234707?pdf=render

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:21965666

https://europepmc.org/articles/PMC3234707

13 December 2024

file format

HyperText Markup Language

online access status

open access

content deliverer

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:21965666

https://europepmc.org/articles/PMC3234707?pdf=render

13 December 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:21965666

https://doi.org/10.1074/jbc.r111.288308

13 December 2024

online access status

open access

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:21965666

https://api.elsevier.com/content/article/PII:S0021925820505413?httpAccept=text/xml

13 December 2024

1 reference

https://api.crossref.org/works/10.1074/JBC.R111.288308

https://api.elsevier.com/content/article/PII:S0021925820505413?httpAccept=text/plain

13 December 2024

1 reference

https://api.crossref.org/works/10.1074/JBC.R111.288308

https://syndication.highwire.org/content/doi/10.1074/jbc.R111.288308

13 December 2024

1 reference

https://api.crossref.org/works/10.1074/JBC.R111.288308

Journal of Biological Chemistry

13 December 2024

published in

1 reference

9 August 2017

volume

286

1 reference

9 August 2017

issue

45

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9 August 2017

page(s)

38825-38832

1 reference

Potent amyloidogenicity and pathogenicity of Aβ43.

9 August 2017

cites work

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Neuroprotective natural antibodies to assemblies of amyloidogenic peptides decrease with normal aging and advancing Alzheimer's disease.

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27 July 2018

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Aminopeptidase A contributes to the N-terminal truncation of amyloid beta-peptide

27 July 2018

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27 July 2018

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Amyloidogenic processing of amyloid precursor protein: evidence of a pivotal role of glutaminyl cyclase in generation of pyroglutamate-modified amyloid-beta

27 July 2018

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Isolation of an isoenzyme of human glutaminyl cyclase: retention in the Golgi complex suggests involvement in the protein maturation machinery

27 July 2018

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27 July 2018

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Inhibition of glutaminyl cyclase alters pyroglutamate formation in mammalian cells

27 July 2018

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A specific amyloid-beta protein assembly in the brain impairs memory

27 July 2018

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Biological significance of isoaspartate and its repair system

27 July 2018

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Role of water-soluble amyloid-beta in the pathogenesis of Alzheimer's disease

27 July 2018

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27 July 2018

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Massive CA1/2 neuronal loss with intraneuronal and N-terminal truncated Abeta42 accumulation in a novel Alzheimer transgenic model

27 July 2018

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Glutaminyl cyclases unfold glutamyl cyclase activity under mild acid conditions

27 July 2018

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Identification of human glutaminyl cyclase as a metalloenzyme. Potent inhibition by imidazole derivatives and heterocyclic chelators

27 July 2018

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Beta-secretase processing in the trans-Golgi network preferentially generates truncated amyloid species that accumulate in Alzheimer's disease brain

27 July 2018

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Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease

27 July 2018

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Amino-terminal modification and tyrosine phosphorylation of [corrected] carboxy-terminal fragments of the amyloid precursor protein in Alzheimer's disease and Down's syndrome brain

27 July 2018

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27 July 2018

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27 July 2018

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27 July 2018

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27 July 2018

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27 July 2018

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27 July 2018

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27 July 2018

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27 July 2018

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27 July 2018

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27 July 2018

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27 July 2018

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Structural alterations in the peptide backbone of beta-amyloid core protein may account for its deposition and stability in Alzheimer's disease.

27 July 2018

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27 July 2018

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27 July 2018

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27 July 2018

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27 July 2018

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Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43).

27 July 2018

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Racemization: its biological significance on neuropathogenesis of Alzheimer's disease

27 July 2018

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27 July 2018

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Isolation and partial characterization of neurofibrillary tangles and amyloid plaque core in Alzheimer's disease: immunohistological studies

27 July 2018

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Isolation of low-molecular-weight proteins from amyloid plaque fibers in Alzheimer's disease

27 July 2018

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27 July 2018

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27 July 2018

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27 July 2018

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27 July 2018

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27 July 2018

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Amyloid deposition as the central event in the aetiology of Alzheimer's disease

27 July 2018

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Alzheimer's disease: the amyloid cascade hypothesis

27 July 2018

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Motor deficits, neuron loss, and reduced anxiety coinciding with axonal degeneration and intraneuronal Aβ aggregation in the 5XFAD mouse model of Alzheimer's disease

27 July 2018

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Mass spectrometric characterization of brain amyloid beta isoform signatures in familial and sporadic Alzheimer's disease

25 September 2018

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25 September 2018

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Pyroglutamate Abeta pathology in APP/PS1KI mice, sporadic and familial Alzheimer's disease cases

25 September 2018

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Developmental expression and subcellular localization of glutaminyl cyclase in mouse brain

25 September 2018

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APP/PS1KI bigenic mice develop early synaptic deficits and hippocampus atrophy

25 September 2018

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Transient intraneuronal A beta rather than extracellular plaque pathology correlates with neuron loss in the frontal cortex of APP/PS1KI mice

25 September 2018

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Glutaminyl cyclase inhibition attenuates pyroglutamate Abeta and Alzheimer's disease-like pathology

25 September 2018

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Longitudinal, quantitative assessment of amyloid, neuroinflammation, and anti-amyloid treatment in a living mouse model of Alzheimer's disease enabled by positron emission tomography

25 September 2018

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Deficits in working memory and motor performance in the APP/PS1ki mouse model for Alzheimer's disease

25 September 2018

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Monoclonal antibodies that target pathological assemblies of Abeta

25 September 2018

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Age-dependent axonal degeneration in an Alzheimer mouse model.

25 September 2018

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Quantification of Alzheimer pathology in ageing and dementia: age-related accumulation of amyloid-beta(42) peptide in vascular dementia.

25 September 2018

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beta-amyloid is different in normal aging and in Alzheimer disease.

25 September 2018

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Amyloid beta protein immunotherapy neutralizes Abeta oligomers that disrupt synaptic plasticity in vivo

25 September 2018

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A modified beta-amyloid hypothesis: intraneuronal accumulation of the beta-amyloid peptide--the first step of a fatal cascade

25 September 2018

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Oligomerization of Alzheimer's beta-amyloid within processes and synapses of cultured neurons and brain.

25 September 2018

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Metal binding and oxidation of amyloid-beta within isolated senile plaque cores: Raman microscopic evidence

25 September 2018

1 reference

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Antibodies to beta-amyloid decrease the blood-to-brain transfer of beta-amyloid peptide

25 September 2018

1 reference

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Soluble oligomers of beta amyloid (1-42) inhibit long-term potentiation but not long-term depression in rat dentate gyrus.

25 September 2018

1 reference

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On-line high-performance liquid chromatography/mass spectrometric investigation of amyloid-beta peptide variants found in Alzheimer's disease.

25 September 2018

1 reference

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Toxicity of pyroglutaminated amyloid beta-peptides 3(pE)-40 and -42 is similar to that of A beta1-40 and -42.

25 September 2018

1 reference

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Quantification of modified amyloid beta peptides in Alzheimer disease and Down syndrome brains

25 September 2018

1 reference

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Irreversible dimerization/tetramerization and post-translational modifications inhibit proteolytic degradation of A beta peptides of Alzheimer's disease

25 September 2018

1 reference

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Amyloid β-Protein (Aβ) 1–40 But Not Aβ1–42 Contributes to the Experimental Formation of Alzheimer Disease Amyloid Fibrils in Rat Brain

25 September 2018

1 reference

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Sequence of deposition of heterogeneous amyloid beta-peptides and APO E in Down syndrome: implications for initial events in amyloid plaque formation.

25 September 2018

1 reference

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Peptide compositions of the cerebrovascular and senile plaque core amyloid deposits of Alzheimer's disease

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234707

Dominant and differential deposition of distinct beta-amyloid peptide species, A beta N3(pE), in senile plaques.

25 September 2018

1 reference

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Amino-terminal Deletions Enhance Aggregation of β-Amyloid Peptides in Vitro

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234707

The isolation and amino acid composition of senile plaque core protein.

25 September 2018

1 reference

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Differences between vascular and plaque core amyloid in Alzheimer's disease

25 September 2018

1 reference

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Mass spectrometry of purified amyloid beta protein in Alzheimer's disease

25 September 2018

1 reference

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Phosphorylation of amyloid-beta at the serine 26 residue by human cdc2 kinase

25 September 2018

1 reference

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Presenilin-1 mutations in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.R111.288308

High-resolution separation of amyloid beta-peptides: structural variants present in Alzheimer's disease amyloid

21 January 2018

1 reference

12 December 2020

The oligomerization of amyloid beta-protein begins intracellularly in cells derived from human brain

1 reference

12 December 2020

Amyloid beta protein starting pyroglutamate at position 3 is a major component of the amyloid deposits in the Alzheimer's disease brain

1 reference

12 December 2020

On the seeding and oligomerization of pGlu-amyloid peptides (in vitro)

1 reference

12 December 2020

Reduced levels of IgM autoantibodies against N-truncated pyroglutamate Aβ in plasma of patients with Alzheimer's disease

1 reference

12 December 2020

N-truncated amyloid-beta oligomers induce learning impairment and neuronal apoptosis

1 reference

12 December 2020

Identifiers

1 reference

9 August 2017

1 reference

9 August 2017

1 reference