PI3K/Akt and apoptosis: size matters (Q35603373)

9 August 2017

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title

PI3K/Akt and apoptosis: size matters (English)

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9 August 2017

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Thomas F Franke

1

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9 August 2017

Christoph P Hornik

2

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9 August 2017

Lisa Segev

3

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9 August 2017

Grigoriy A Shostak

4

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9 August 2017

Chizuru Sugimoto

5

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9 August 2017

language of work or name

English

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publication date

1 December 2003

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9 August 2017

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9 August 2017

volume

22

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9 August 2017

issue

56

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9 August 2017

page(s)

8983-8998

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Mechanism of activation and function of protein kinase B.

9 August 2017

cites work

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Akt phosphorylation site found in human caspase-9 is absent in mouse caspase-9.

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Increased AKT activity contributes to prostate cancer progression by dramatically accelerating prostate tumor growth and diminishing p27Kip1 expression

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Phosphorylation of serine 256 by protein kinase B disrupts transactivation by FKHR and mediates effects of insulin on insulin-like growth factor-binding protein-1 promoter activity through a conserved insulin response sequence

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Insulin and insulin-like growth factor-1 regulate tau phosphorylation in cultured human neurons.

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Protein kinase B regulates T lymphocyte survival, nuclear factor kappaB activation, and Bcl-X(L) levels in vivo

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Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation

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Molecular cloning of rat RAC protein kinase alpha and beta and their association with protein kinase C zeta

21 January 2018

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Novel PI analogues selectively block activation of the pro-survival serine/threonine kinase Akt.

21 January 2018

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Akt protein kinase inhibits Rac1-GTP binding through phosphorylation at serine 71 of Rac1.

21 January 2018

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Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family

21 January 2018

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The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

21 January 2018

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Prostate intraepithelial neoplasia induced by prostate restricted Akt activation: the MPAKT model

21 January 2018

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Tumor induction by an Lck-MyrAkt transgene is delayed by mechanisms controlling the size of the thymus

21 January 2018

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A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus

21 January 2018

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https://api.crossref.org/works/10.1038/SJ.ONC.1207115

Mitogenic activation, phosphorylation, and nuclear translocation of protein kinase Bbeta

21 January 2018

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https://api.crossref.org/works/10.1038/SJ.ONC.1207115

FOXO proteins regulate tumor necrosis factor-related apoptosis inducing ligand expression. Implications for PTEN mutation in prostate cancer

21 January 2018

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https://api.crossref.org/works/10.1038/SJ.ONC.1207115

Bad can act as a key regulator of T cell apoptosis and T cell development.

21 January 2018

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https://api.crossref.org/works/10.1038/SJ.ONC.1207115

PTEN: sometimes taking it off can be better than putting it on.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1207115

Insulin stimulates phosphorylation of the forkhead transcription factor FKHR on serine 253 through a Wortmannin-sensitive pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1207115

Identification and characterization of the interaction between tuberin and 14-3-3zeta

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1207115

Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR.

21 January 2018

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https://api.crossref.org/works/10.1038/SJ.ONC.1207115

The protein kinase B/Akt signalling pathway in human malignancy

21 January 2018

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https://api.crossref.org/works/10.1038/SJ.ONC.1207115

Peptide and protein library screening defines optimal substrate motifs for AKT/PKB.

21 January 2018

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https://api.crossref.org/works/10.1038/SJ.ONC.1207115

Akt enhances Mdm2-mediated ubiquitination and degradation of p53.

21 January 2018

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https://api.crossref.org/works/10.1038/SJ.ONC.1207115

Role of glycogen synthase kinase-3 in the phosphatidylinositol 3-Kinase/Akt cell survival pathway

21 January 2018

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https://api.crossref.org/works/10.1038/SJ.ONC.1207115

Akt and Bcl-xL promote growth factor-independent survival through distinct effects on mitochondrial physiology

21 January 2018

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https://api.crossref.org/works/10.1038/SJ.ONC.1207115

Akt activation promotes degradation of tuberin and FOXO3a via the proteasome

21 January 2018

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https://api.crossref.org/works/10.1038/SJ.ONC.1207115

An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten /- mice

21 January 2018

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https://api.crossref.org/works/10.1038/SJ.ONC.1207115

The role of phosphoinositide 3-kinase lipid products in cell function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1207115

Postmitochondrial regulation of apoptosis during heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1207115

Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1207115

Modulation of Akt kinase activity by binding to Hsp90

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1207115

Dissociation of cytokine-induced phosphorylation of Bad and activation of PKB/akt: involvement of MEK upstream of Bad phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1207115

Regulation of bad phosphorylation and association with Bcl-x(L) by the MAPK/Erk kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1207115

PKB/AKT: functional insights from genetic models

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1207115

14-3-3beta binds to and negatively regulates the tuberous sclerosis complex 2 (TSC2) tumor suppressor gene product, tuberin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1207115

Isolation of transforming murine leukemia viruses from mice with a high incidence of spontaneous lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1207115

Activity-dependent NMDA receptor-mediated activation of protein kinase B/Akt in cortical neuronal cultures

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1207115

BAD Ser-155 phosphorylation regulates BAD/Bcl-XL interaction and cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1207115

p90(RSK) blocks bad-mediated cell death via a protein kinase C-dependent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1207115

Negative regulation of the forkhead transcription factor FKHR by Akt.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1207115

Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1207115

Crystal structure of an activated Akt/protein kinase B ternary complex with GSK3-peptide and AMP-PNP

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1207115

AKT2 inhibition of cisplatin-induced JNK/p38 and Bax activation by phosphorylation of ASK1: implication of AKT2 in chemoresistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1207115

Akt regulates cell survival and apoptosis at a postmitochondrial level

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1207115

Inhibition of Akt kinase by cell-permeable ceramide and its implications for ceramide-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1207115

Phosphorylation and Activation of Heart 6-Phosphofructo-2-kinase by Protein Kinase B and Other Protein Kinases of the Insulin Signaling Cascades

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1207115

High Affinity Binding of Inositol Phosphates and Phosphoinositides to the Pleckstrin Homology Domain of RAC/Protein Kinase B and Their Influence on Kinase Activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1207115

Phosphorylation of HDM2 by Akt.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1207115

7 January 2021

The integrin-linked kinase (ILK) suppresses anoikis

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https://api.crossref.org/works/10.1038/SJ.ONC.1207115

7 January 2021

AKT2 is frequently upregulated in HER-2/neu-positive breast cancers and may contribute to tumor aggressiveness by enhancing cell survival

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https://api.crossref.org/works/10.1038/SJ.ONC.1207115

7 January 2021

A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region

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7 January 2021

Brain-derived neurotrophic factor mediates the anti-apoptotic effect of NMDA in cerebellar granule neurons: signal transduction cascades and site of ethanol action.

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7 January 2021

Are p27 and p21 cytoplasmic oncoproteins?

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7 January 2021

Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms

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7 January 2021

PKB binding proteins. Getting in on the Akt.

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7 January 2021

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

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7 January 2021

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

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https://api.crossref.org/works/10.1038/SJ.ONC.1207115

7 January 2021

Regulation of cell death protease caspase-9 by phosphorylation

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https://api.crossref.org/works/10.1038/SJ.ONC.1207115

7 January 2021

Involvement of PI3K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer chemotherapy.

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7 January 2021

Transformation of chicken cells by the gene encoding the catalytic subunit of PI 3-kinase

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https://api.crossref.org/works/10.1038/SJ.ONC.1207115

7 January 2021

Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice

1 reference

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7 January 2021

Dissociation of apoptosis from proliferation, protein kinase B activation, and BAD phosphorylation in interleukin-3-mediated phosphoinositide 3-kinase signaling

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1207115

7 January 2021

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1207115

7 January 2021

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

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https://api.crossref.org/works/10.1038/SJ.ONC.1207115

7 January 2021

Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt

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https://api.crossref.org/works/10.1038/SJ.ONC.1207115

7 January 2021

Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1207115

7 January 2021

TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1207115

7 January 2021

Regulation of neuronal survival by the serine-threonine protein kinase Akt

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1207115

7 January 2021

Phosphoinositide 3-kinase regulation of T cell receptor-mediated interleukin-2 gene expression in normal T cells

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1207115

7 January 2021

Regulation of longevity and stress resistance by Sch9 in yeast

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1207115

7 January 2021

Oxidants, oxidative stress and the biology of ageing

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https://api.crossref.org/works/10.1038/SJ.ONC.1207115

7 January 2021

A Bad kinase makes good

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https://api.crossref.org/works/10.1038/SJ.ONC.1207115

7 January 2021

PI3K: downstream AKTion blocks apoptosis

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1207115

7 January 2021

Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1207115

7 January 2021

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1207115

7 January 2021

PTEN tumor suppressor regulates p53 protein levels and activity through phosphatase-dependent and -independent mechanisms

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1207115

7 January 2021

Regulation of endothelium-derived nitric oxide production by the protein kinase Akt

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1207115

7 January 2021

Apoptosis meets signal transduction: elimination of a BAD influence

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1207115

7 January 2021

Characterization of PDK2 activity against protein kinase B gamma

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1207115

7 January 2021

Phosphorylation and nuclear exclusion of the forkhead transcription factor FKHR after epidermal growth factor treatment in human breast cancer cells.

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1207115

7 January 2021

Molecular cloning of a second form of rac protein kinase

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1207115

7 January 2021

Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1207115

7 January 2021

Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB.

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1207115

7 January 2021

Akt1 regulates a JNK scaffold during excitotoxic apoptosis

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1207115

7 January 2021

Current status of the molecular mechanisms of anticancer drug-induced apoptosis. The contribution of molecular-level analysis to cancer chemotherapy

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1207115

7 January 2021

Direct control of the Forkhead transcription factor AFX by protein kinase B

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1207115

7 January 2021

AKT/PKB phosphorylation of p21Cip/WAF1 enhances protein stability of p21Cip/WAF1 and promotes cell survival

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1207115

7 January 2021

Regulation of TSC2 by 14-3-3 binding

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1207115

7 January 2021

p53 regulates Stat3 phosphorylation and DNA binding activity in human prostate cancer cells expressing constitutively active Stat3.

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1207115

7 January 2021

Integrin-linked kinase regulates phosphorylation of serine 473 of protein kinase B by an indirect mechanism

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1207115

7 January 2021

Carboxyl-terminal modulator protein (CTMP), a negative regulator of PKB/Akt and v-Akt at the plasma membrane

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1207115

7 January 2021

Adenoviral gene transfer of activated phosphatidylinositol 3'-kinase and Akt inhibits apoptosis of hypoxic cardiomyocytes in vitro

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1207115

7 January 2021

AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1207115

7 January 2021

Identification of a human Akt3 (protein kinase B gamma) which contains the regulatory serine phosphorylation site.

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1207115

7 January 2021

Up-regulation of Akt3 in estrogen receptor-deficient breast cancers and androgen-independent prostate cancer lines.

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1207115

7 January 2021

Signal transduction. Are there close encounters between signaling pathways?

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1207115

7 January 2021

Insulin-like growth factor-I inhibits the stress-activated protein kinase/c-Jun N-terminal kinase.

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1207115

7 January 2021

Induction of ovarian cancer by defined multiple genetic changes in a mouse model system

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1207115

7 January 2021

Tumor necrosis factor induces phosphorylation and translocation of BAD through a phosphatidylinositide-3-OH kinase-dependent pathway

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1207115

7 January 2021

Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1207115

7 January 2021

Social controls on cell survival and cell death

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1207115

7 January 2021

A novel mechanism of gene regulation and tumor suppression by the transcription factor FKHR.

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1207115

7 January 2021

Apoptosis-targeted therapies for cancer

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1207115

7 January 2021

Differentiation stage-specific inhibition of the Raf-MEK-ERK pathway by Akt.

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1207115

7 January 2021

The conserved PI3'K/PTEN/Akt signaling pathway regulates both cell size and survival in Drosophila

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1207115

7 January 2021

Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1207115

7 January 2021

Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1207115

7 January 2021

The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1207115

7 January 2021

Akt/protein kinase B is regulated by autophosphorylation at the hypothetical PDK-2 site

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1207115

7 January 2021

Cellular signaling: pivoting around PDK-1.

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1207115

7 January 2021

DNA repair pathway stimulated by the forkhead transcription factor FOXO3a through the Gadd45 protein

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1207115

7 January 2021

Ca2 -induced apoptosis through calcineurin dephosphorylation of BAD

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1207115

7 January 2021

Mutant presenilin-1 induces apoptosis and downregulates Akt/PKB.

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1207115

7 January 2021

Insulin-induced phosphorylation and activation of phosphodiesterase 3B in rat adipocytes: possible role for protein kinase B but not mitogen-activated protein kinase or p70 S6 kinase

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1207115

7 January 2021

Calcium promotes cell survival through CaM-K kinase activation of the protein-kinase-B pathway

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1207115

7 January 2021

Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1207115

7 January 2021

Apoptosis in the nervous system

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1207115

7 January 2021

Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1207115

7 January 2021

Human mammary epithelial cell transformation through the activation of phosphatidylinositol 3-kinase

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1207115

7 January 2021

Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1207115

7 January 2021

HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1207115

7 January 2021

Phosphorylation and regulation of Raf by Akt (protein kinase B)

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1207115

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1207115

1 reference

Dimensions Publication ID

9 August 2017

1002235389

0 references

1 reference