Synergy between TLR9 and NOD2 innate immune responses is lost in genetic Crohn's disease (Q35597925)

9 August 2017

title

Synergy between TLR9 and NOD2 innate immune responses is lost in genetic Crohn's disease (English)

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9 August 2017

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Christopher G. Mathew

4

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9 August 2017

D A van Heel

1

1 reference

9 August 2017

S Ghosh

2

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9 August 2017

K A Hunt

3

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9 August 2017

A Forbes

5

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9 August 2017

D P Jewell

6

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9 August 2017

R J Playford

7

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9 August 2017

language of work or name

English

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publication date

31 May 2005

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9 August 2017

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9 August 2017

volume

54

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9 August 2017

issue

11

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9 August 2017

page(s)

1553-1557

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GRIM-19 interacts with nucleotide oligomerization domain 2 and serves as downstream effector of anti-bacterial function in intestinal epithelial cells

9 August 2017

cites work

1 reference

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Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract

12 July 2018

1 reference

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War and peace at mucosal surfaces

12 July 2018

1 reference

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Identification of bacterial muramyl dipeptide as activator of the NALP3/cryopyrin inflammasome.

12 July 2018

1 reference

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The role of Toll-like receptors and Nod proteins in bacterial infection

12 July 2018

1 reference

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Degranulation of paneth cells via toll-like receptor 9.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1774767

Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1774767

NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1774767

Heterotypic interactions among NACHT domains: implications for regulation of innate immune responses

12 July 2018

1 reference

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Reciprocal cross-talk between Nod2 and TAK1 signaling pathways

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1774767

Of mice and not men: differences between mouse and human immunology

12 July 2018

1 reference

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Expression of NOD2 in Paneth cells: a possible link to Crohn's ileitis

12 July 2018

1 reference

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Bacterial DNA evokes epithelial IL-8 production by a MAPK-dependent, NF-kappaB-independent pathway

12 July 2018

1 reference

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Rational design of new CpG oligonucleotides that combine B cell activation with high IFN-alpha induction in plasmacytoid dendritic cells

12 July 2018

1 reference

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The molecular classification of the clinical manifestations of Crohn's disease

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1774767

RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1774767

CARD15/NOD2 mutational analysis and genotype-phenotype correlation in 612 patients with inflammatory bowel disease

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1774767

A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1774767

Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1774767

Synergistic effect of muramyldipeptide with lipopolysaccharide or lipoteichoic acid to induce inflammatory cytokines in human monocytic cells in culture

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1774767

A simple classification of Crohn's disease: report of the Working Party for the World Congresses of Gastroenterology, Vienna 1998.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1774767

Muramyl dipeptide and toll-like receptor sensitivity in NOD2-associated Crohn's disease

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1774767

Nod2 mutation in Crohn's disease potentiates NF-kappaB activity and IL-1beta processing

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1774767

Differential effects of NOD2 variants on Crohn's disease risk and phenotype in diverse populations: a metaanalysis.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1774767

Regulation of IL-8 and IL-1beta expression in Crohn's disease associated NOD2/CARD15 mutations

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1774767

Stimulation of peripheral blood and intestinal mucosa cells by synthetic CpG oligodeoxynucleotides

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1774767

Toll-like receptor 9 signaling mediates the anti-inflammatory effects of probiotics in murine experimental colitis.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1774767

Structural requirements of synthetic muropeptides to synergize with lipopolysaccharide in cytokine induction

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1774767

CD4 and CD8 cells in cryopreserved human PBMC maintain full functionality in cytokine ELISPOT assays

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1774767

Fine mapping of theIBD1 locus did not identify Crohn disease-associatedNOD2 variants: Implications for complex disease genetics

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1774767

Crohn's disease: genetic susceptibility, bacteria, and innate immunity

15 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15928043

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Association between insertion mutation in NOD2 gene and Crohn's disease in German and British populations

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15928043

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Muramyldipeptide and diaminopimelic acid-containing desmuramylpeptides in combination with chemically synthesized Toll-like receptor agonists synergistically induced production of interleukin-8 in a NOD2- and NOD1-dependent manner, respectively, in h

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15928043

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1136/GUT.2005.065888

1 reference

9 August 2017

1 reference

9 August 2017

1 reference