4-1BB Signaling Enhances Primary and Secondary Population Expansion of CD8 T Cells by Maximizing Autocrine IL-2/IL-2 Receptor Signaling (Q35593150)

9 August 2017

title

4-1BB Signaling Enhances Primary and Secondary Population Expansion of CD8 T Cells by Maximizing Autocrine IL-2/IL-2 Receptor Signaling (English)

1 reference

9 August 2017

Ho S Oh

1

1 reference

9 August 2017

Beom K Choi

2

1 reference

9 August 2017

Young H Kim

3

1 reference

9 August 2017

Don G Lee

4

1 reference

9 August 2017

Sunhee Hwang

5

1 reference

9 August 2017

Myoung J Lee

6

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9 August 2017

Sang H Park

7

1 reference

9 August 2017

Yong-Soo Bae

8

1 reference

9 August 2017

Byoung S Kwon

9

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9 August 2017

language of work or name

English

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publication date

11 May 2015

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9 August 2017

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9 August 2017

volume

10

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9 August 2017

issue

5

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9 August 2017

page(s)

e0126765

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Creative Commons Attribution 4.0 International

9 August 2017

copyright license

start time

11 May 2015

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

4-1BB signaling activates the t cell factor 1 effector/β-catenin pathway with delayed kinetics via ERK signaling and delayed PI3K/AKT activation to promote the proliferation of CD8 T Cells

1 reference

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Interleukin-2 at the crossroads of effector responses, tolerance, and immunotherapy

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4427336

Autocrine IL-2 is required for secondary population expansion of CD8( ) memory T cells

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4427336

Immune regulation by 4-1BB and 4-1BBL: complexities and challenges

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4427336

Homeostasis of naive and memory T cells

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4427336

Interleukin 2: from immunostimulation to immunoregulation and back again

12 July 2018

1 reference

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Interleukin-2 signals during priming are required for secondary expansion of CD8 memory T cells.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4427336

Removal of homeostatic cytokine sinks by lymphodepletion enhances the efficacy of adoptively transferred tumor-specific CD8 T cells

12 July 2018

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HIV-1-specific IFN-gamma/IL-2-secreting CD8 T cells support CD4-independent proliferation of HIV-1-specific CD8 T cells.

12 July 2018

1 reference

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Phosphoinositide 3-kinase: diverse roles in immune cell activation

12 July 2018

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Effector differentiation is not prerequisite for generation of memory cytotoxic T lymphocytes

12 July 2018

1 reference

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IL-7 is critical for homeostatic proliferation and survival of naive T cells

12 July 2018

1 reference

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Anti-4-1BB monoclonal antibodies abrogate T cell-dependent humoral immune responses in vivo through the induction of helper T cell anergy

12 July 2018

1 reference

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CD28-independent, TRAF2-dependent costimulation of resting T cells by 4-1BB ligand

12 July 2018

1 reference

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4-1BB costimulatory signals preferentially induce CD8 T cell proliferation and lead to the amplification in vivo of cytotoxic T cell responses

12 July 2018

1 reference

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Interleukin-2 induction of T-cell G1 progression and c-myb expression

12 July 2018

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Prolonged interleukin-2Ralpha expression on virus-specific CD8 T cells favors terminal-effector differentiation in vivo.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4427336

IL-15 is required for sustained lymphopenia-driven proliferation and accumulation of CD8 T cells.

26 September 2018

1 reference

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Differential role of IL-2R signaling for CD8 T cell responses in acute and chronic viral infections.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4427336

4-1BB enhances CD8 T cell expansion by regulating cell cycle progression through changes in expression of cyclins D and E and cyclin-dependent kinase inhibitor p27kip1.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4427336

Selective delivery of augmented IL-2 receptor signals to responding CD8 T cells increases the size of the acute antiviral response and of the resulting memory T cell pool

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4427336

High numbers of IL-2-producing CD8 T cells during viral infection: correlation with stable memory development.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4427336

Temporal segregation of 4-1BB versus CD28-mediated costimulation: 4-1BB ligand influences T cell numbers late in the primary response and regulates the size of the T cell memory response following influenza infection

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4427336

Role of 4-1BB in immune responses

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4427336

The duration of antigenic stimulation determines the fate of naive and effector T cells

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4427336

Endogenous IL-2 contributes to T cell expansion and IFN-gamma production during lymphocytic choriomeningitis virus infection.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4427336

Signals through 4-1BB are costimulatory to previously activated splenic T cells and inhibit activation-induced cell death

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4427336

Cutting edge: 4-1BB is a bona fide CD8 T cell survival signal

26 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25962156

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Efficient induction of primary and secondary T cell-dependent immune responses in vivo in the absence of functional IL-2 and IL-15 receptors

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25962156

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PONE.0126765

1 reference

9 August 2017

0 references

1 reference

9 August 2017

1 reference