Runx1 loss minimally impacts long-term hematopoietic stem cells (Q35586823)

9 August 2017

title

Runx1 loss minimally impacts long-term hematopoietic stem cells (English)

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9 August 2017

Patricia Ernst

7

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author name string

Xiongwei Cai

1

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9 August 2017

Justin J Gaudet

2

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9 August 2017

James K Mangan

3

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9 August 2017

Michael J Chen

4

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9 August 2017

Maria Elena De Obaldia

5

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9 August 2017

Zaw Oo

6

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9 August 2017

Nancy A Speck

8

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9 August 2017

language of work or name

English

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publication date

1 December 2011

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9 August 2017

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9 August 2017

volume

6

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9 August 2017

issue

12

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9 August 2017

page(s)

e28430

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Creative Commons Attribution 4.0 International

9 August 2017

copyright license

start time

1 December 2011

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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Prdm16 promotes stem cell maintenance in multiple tissues, partly by regulating oxidative stress

12 July 2018

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Stem cell exhaustion due to Runx1 deficiency is prevented by Evi5 activation in leukemogenesis

12 July 2018

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RUNX1 and its fusion oncoprotein derivative, RUNX1-ETO, induce senescence-like growth arrest independently of replicative stress

12 July 2018

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Cell cycle and developmental control of hematopoiesis by Runx1.

12 July 2018

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Runx1 is required for the endothelial to haematopoietic cell transition but not thereafter

12 July 2018

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p53 regulates hematopoietic stem cell quiescence.

12 July 2018

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Runx expression is mitogenic and mutually linked to Wnt activity in blastula-stage sea urchin embryos

12 July 2018

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Unique and independent roles for MLL in adult hematopoietic stem cells and progenitors

12 July 2018

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AML1/Runx1 negatively regulates quiescent hematopoietic stem cells in adult hematopoiesis.

12 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3228772

Runx1 modulates developmental, but not injury-driven, hair follicle stem cell activation.

12 July 2018

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Leukemia and hematopoietic stem cells: balancing proliferation and quiescence.

12 July 2018

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Deconstructing stem cell self-renewal: genetic insights into cell-cycle regulation

12 July 2018

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Isoform-specific potentiation of stem and progenitor cell engraftment by AML1/RUNX1

12 July 2018

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NOV (CCN3) functions as a regulator of human hematopoietic stem or progenitor cells

12 July 2018

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Identification of a new intrinsically timed developmental checkpoint that reprograms key hematopoietic stem cell properties

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3228772

FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3228772

Hematopoietic stem cells proliferate until after birth and show a reversible phase-specific engraftment defect

12 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3228772

Monocytic leukemia zinc finger protein is essential for the development of long-term reconstituting hematopoietic stem cells

12 July 2018

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Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells

12 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3228772

mab-2 encodes RNT-1, a C. elegans Runx homologue essential for controlling cell proliferation in a stem cell-like developmental lineage

12 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3228772

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles

12 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3228772

Insertional mutagenesis identifies genes that promote the immortalization of primary bone marrow progenitor cells

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3228772

SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3228772

Loss of Runx1 perturbs adult hematopoiesis and is associated with a myeloproliferative phenotype.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3228772

Role for Runx1 in the proliferation and neuronal differentiation of selected progenitor cells in the mammalian nervous system.

12 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3228772

Identification of Lin(-)Sca1( )kit( )CD34( )Flt3- short-term hematopoietic stem cells capable of rapidly reconstituting and rescuing myeloablated transplant recipients.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3228772

Transcription factor Gfi1 regulates self-renewal and engraftment of hematopoietic stem cells

12 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3228772

RUNX1 transformation of primary embryonic fibroblasts is revealed in the absence of p53.

12 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3228772

AML-1 is required for megakaryocytic maturation and lymphocytic differentiation, but not for maintenance of hematopoietic stem cells in adult hematopoiesis

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3228772

Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3228772

Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3228772

AML1 stimulates G1 to S progression via its transactivation domain

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3228772

Flk-2 is a marker in hematopoietic stem cell differentiation: a simple method to isolate long-term stem cells

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3228772

Dichotomy of AML1-ETO functions: growth arrest versus block of differentiation

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3228772

Exogenous cdk4 overcomes reduced cdk4 RNA and inhibition of G1 progression in hematopoietic cells expressing a dominant-negative CBF - a model for overcoming inhibition of proliferation by CBF oncoproteins

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3228772

Expression of the AML-1 oncogene shortens the G(1) phase of the cell cycle

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3228772

Frequency of prolonged remission duration after high-dose cytarabine intensification in acute myeloid leukemia varies by cytogenetic subtype.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3228772

Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3228772

AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3228772

Primitive hemopoietic stem cells: direct assay of most productive populations by competitive repopulation with simple binomial, correlation and covariance calculations.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3228772

Genetic variegation of clonal architecture and propagating cells in leukaemia

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3228772

AML1/RUNX1 mutations in 470 adult patients with de novo acute myeloid leukemia: prognostic implication and interaction with other gene alterations.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3228772

Necdin restricts proliferation of hematopoietic stem cells during hematopoietic regeneration

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3228772

RUNX1 mutations are frequent in chronic myelomonocytic leukemia and mutations at the C-terminal region might predict acute myeloid leukemia transformation

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3228772

Analysis of histone 2B-GFP retention reveals slowly cycling hematopoietic stem cells

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3228772

High frequency of AML1/RUNX1 point mutations in radiation-associated myelodysplastic syndrome around Semipalatinsk nuclear test site

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3228772

Initiating and cancer-propagating cells in TEL-AML1-associated childhood leukemia

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3228772

CBFbeta-SMMHC slows proliferation of primary murine and human myeloid progenitors

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3228772

Assessing the role of hematopoietic plasticity for endothelial and hepatocyte development by non-invasive lineage tracing

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3228772

Gfi-1 restricts proliferation and preserves functional integrity of haematopoietic stem cells

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3228772

Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3228772

The t(8;21) fusion protein, AML1 ETO, specifically represses the transcription of the p14(ARF) tumor suppressor in acute myeloid leukemia

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3228772

Next-Generation Sequencing Technology Reveals a Characteristic Pattern of Molecular Mutations in 72.8% of Chronic Myelomonocytic Leukemia by Detecting Frequent Alterations in TET2, CBL, RAS, and RUNX1

26 September 2018

1 reference

https://api.crossref.org/works/10.1371/JOURNAL.PONE.0028430

TEL-AML1 Corrupts Hematopoietic Stem Cells to Persist in the Bone Marrow and Initiate Leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1371/JOURNAL.PONE.0028430

Critical Role of Thrombopoietin in Maintaining Adult Quiescent Hematopoietic Stem Cells

21 January 2018

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https://api.crossref.org/works/10.1371/JOURNAL.PONE.0028430

PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention

21 January 2018

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https://api.crossref.org/works/10.1371/JOURNAL.PONE.0028430

Hematopoietic stem cells found in lineage-positive subsets in the bone marrow of 5-fluorouracil-treated mice

21 January 2018

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12 December 2020

CBFβ-SMMHC, expressed in M4Eo AML, reduced CBF DNA-binding and inhibited the G1 to S cell cycle transition at the restriction point in myeloid and lymphoid cells

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12 December 2020

Biallelic and heterozygous point mutations in the runt domain of the AML1/PEBP2alphaB gene associated with myeloblastic leukemias

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12 December 2020

X-ray sensitivity and DNA synthesis in synchronous populations of HeLa cells

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12 December 2020

RUNX1 mutations are frequent in de novo AML with noncomplex karyotype and confer an unfavorable prognosis

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12 December 2020

Implications of somatic mutations in the AML1 gene in radiation-associated and therapy-related myelodysplastic syndrome/acute myeloid leukemia

1 reference

12 December 2020

X-ray sensitivity during the cell generation cycle of cultured Chinese hamster cells

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12 December 2020

Runx1 protects hematopoietic stem/progenitor cells from oncogenic insult

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12 December 2020

10.1371/JOURNAL.PONE.0028430

Identifiers

DOI

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9 August 2017

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9 August 2017

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