Regulation of Pancreatic .BETA.-cell Function by the HNF Transcription Network: Lessons from Maturity-Onset Diabetes of the Young (MODY) (Q35582328)

9 August 2017

1 reference

reason for preferred rank

title

Regulation of Pancreatic .BETA.-cell Function by the HNF Transcription Network: Lessons from Maturity-Onset Diabetes of the Young (MODY) (English)

1 reference

https://api.crossref.org/works/10.1507/ENDOCRJ.50.491

1 April 2024

Regulation of pancreatic beta-cell function by the HNF transcription network: lessons from maturity-onset diabetes of the young (MODY) (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:14614204

maturity-onset diabetes of the young

1 April 2024

main subject

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0 references

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:14614204

1 April 2024

1 reference

https://api.crossref.org/works/10.1507/ENDOCRJ.50.491

1 April 2024

author name string

Kazuya Yamagata

1

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9 August 2017

language of work or name

1 reference

1 October 2003

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9 August 2017

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9 August 2017

volume

50

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9 August 2017

issue

5

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9 August 2017

page(s)

491-499

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Mutations in the hepatocyte nuclear factor-1alpha gene in maturity-onset diabetes of the young (MODY3)

9 August 2017

cites work

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1 April 2024

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Mutation in hepatocyte nuclear factor–1β gene (TCF2) associated with MODY

1 April 2024

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Early-onset type-II diabetes mellitus (MODY4) linked to IPF1

1 April 2024

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Mutations in NEUROD1 are associated with the development of type 2 diabetes mellitus

1 April 2024

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Expression profile of MODY3/HNF-1alpha protein in the developing mouse pancreas

1 April 2024

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beta-cell genes and diabetes: molecular and clinical characterization of mutations in transcription factors

1 April 2024

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Altered insulin secretory responses to glucose in diabetic and nondiabetic subjects with mutations in the diabetes susceptibility gene MODY3 on chromosome 12.

1 April 2024

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Sleep apnea causes daytime hypertension

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Nonsense mutation in the glucokinase gene causes early-onset non-insulin-dependent diabetes mellitus

1 April 2024

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Three new mutations in the hepatocyte nuclear factor-1alpha gene in Japanese subjects with diabetes mellitus: clinical features and functional characterization

1 April 2024

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Structure/function studies of hepatocyte nuclear factor-1alpha, a diabetes-associated transcription factor

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Identification of mutations in the hepatocyte nuclear factor (HNF)-1 alpha gene in Japanese subjects with IDDM

1 April 2024

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HNF-1alpha G319S, a transactivation-deficient mutant, is associated with altered dynamics of diabetes onset in an Oji-Cree community

1 April 2024

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Mutations in the Hepatocyte Nuclear Factor-1α/MODY3 Gene in Japanese Subjects With Early- and Late-Onset NIDDM

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Mutations in the Hepatocyte Nuclear Factor-1α Gene (MODY3) Are Not a Major Cause of Late-Onset NIDDM in Japanese Subjects

1 April 2024

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Genetic variation in the hepatocyte nuclear factor-1 alpha gene in Danish Caucasians with late-onset NIDDM.

1 April 2024

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Missense mutations in the insulin promoter factor-1 gene predispose to type 2 diabetes

1 April 2024

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Defective mutations in the insulin promoter factor-1 (IPF-1) gene in late-onset type 2 diabetes mellitus

1 April 2024

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Dominant-negative suppression of HNF-1alpha function results in defective insulin gene transcription and impaired metabolism-secretion coupling in a pancreatic beta-cell line.

1 April 2024

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Overexpression of dominant-negative mutant hepatocyte nuclear fctor-1 alpha in pancreatic beta-cells causes abnormal islet architecture with decreased expression of E-cadherin, reduced beta-cell proliferation, and diabetes.

1 April 2024

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Human insulin gene is a target gene of hepatocyte nuclear factor-1alpha (HNF-1alpha) and HNF-1beta

1 April 2024

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Molecular targets of a human HNF1 alpha mutation responsible for pancreatic beta-cell dysfunction

1 April 2024

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Dominant-negative suppression of HNF-1 alpha results in mitochondrial dysfunction, INS-1 cell apoptosis, and increased sensitivity to ceramide-, but not to high glucose-induced cell death.

1 April 2024

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Hepatocyte nuclear factor-1alpha modulates pancreatic beta-cell growth by regulating the expression of insulin-like growth factor-1 in INS-1 cells

1 April 2024

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Defective insulin secretion in hepatocyte nuclear factor 1alpha-deficient mice

1 April 2024

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A transcription factor regulatory circuit in differentiated pancreatic cells

1 April 2024

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Hepatic nuclear factor 1-alpha directs nucleosomal hyperacetylation to its tissue-specific transcriptional targets

1 April 2024

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Crystal structure of the HNF4 alpha ligand binding domain in complex with endogenous fatty acid ligand

1 April 2024

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Hepatocyte nuclear factor 4 is a transcription factor that constitutively binds fatty acids

1 April 2024

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A distant upstream promoter of the HNF-4alpha gene connects the transcription factors involved in maturity-onset diabetes of the young

1 April 2024

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Genetic evidence that HNF-1α–dependent transcriptional control of HNF-4α is essential for human pancreatic β cell function

1 April 2024

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Maturity-Onset Diabetes of the Young Due to a Mutation in the Hepatocyte Nuclear Factor-4α Binding Site in the Promoter of the Hepatocyte Nuclear Factor-1α Gene

1 April 2024

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Genotype/phenotype relationships in HNF-4alpha/MODY1: haploinsufficiency is associated with reduced apolipoprotein (AII), apolipoprotein (CIII), lipoprotein(a), and triglyceride levels

1 April 2024

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T130I mutation in HNF-4alpha gene is a loss-of-function mutation in hepatocytes and is associated with late-onset Type 2 diabetes mellitus in Japanese subjects

1 April 2024

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Disruption of the HNF-4 gene, expressed in visceral endoderm, leads to cell death in embryonic ectoderm and impaired gastrulation of mouse embryos

1 April 2024

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Hepatocyte nuclear factor 4alpha regulates the expression of pancreatic beta -cell genes implicated in glucose metabolism and nutrient-induced insulin secretion

1 April 2024

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Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1

1 April 2024

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Hepatocyte nuclear factor 4alpha (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis

1 April 2024

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Identification of a gain-of-function mutation in the HNF-1beta gene in a Japanese family with MODY.

1 April 2024

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The mutated human gene encoding hepatocyte nuclear factor 1beta inhibits kidney formation in developing Xenopus embryos

1 April 2024

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Thyroid hormone receptor interacting protein 3 (trip3) is a novel coactivator of hepatocyte nuclear factor-4alpha.

1 April 2024

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R127W-HNF-4alpha is a loss of function mutation but not a rare polymorphism and causes Type II diabetes in a Japanese family with MODY1.

1 April 2024

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Loss of HNF-1alpha function in mice leads to abnormal expression of genes involved in pancreatic islet development and metabolism

1 April 2024

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Small heterodimer partner, an orphan nuclear receptor, augments peroxisome proliferator-activated receptor gamma transactivation

1 April 2024

49

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https://api.crossref.org/works/10.1507/ENDOCRJ.50.491

Identification of missense mutations in the hepatocyte nuclear factor-3beta gene in Japanese subjects with late-onset Type II diabetes mellitus

1 April 2024

50

1 reference

https://api.crossref.org/works/10.1507/ENDOCRJ.50.491

Mutation screening of the hepatocyte nuclear factor (HNF)-6 gene in Japanese subjects with diabetes mellitus

1 April 2024

51

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https://api.crossref.org/works/10.1507/ENDOCRJ.50.491

Hepatocyte nuclear factor-6: associations between genetic variability and type II diabetes and between genetic variability and estimates of insulin secretion

1 April 2024

52

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https://api.crossref.org/works/10.1507/ENDOCRJ.50.491

1 April 2024

Identifiers

1 reference

9 August 2017

1 reference