Tumor suppressors, chromosomal instability, and hepatitis C virus-associated liver cancer. (Q35576670)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18928409 AND SRC:MED&resulttype=core&format=json

24 December 2019

review article

1 reference

title

Tumor suppressors, chromosomal instability, and hepatitis C virus-associated liver cancer (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18928409 AND SRC:MED&resulttype=core&format=json

24 December 2019

1 reference

1 reference

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18928409 AND SRC:MED&resulttype=core&format=json

24 December 2019

author name string

Stanley M Lemon

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18928409 AND SRC:MED&resulttype=core&format=json

24 December 2019

publication date

1 January 2009

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18928409 AND SRC:MED&resulttype=core&format=json

Annual Review of Pathology: Mechanisms of Disease

24 December 2019

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18928409 AND SRC:MED&resulttype=core&format=json

24 December 2019

volume

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18928409 AND SRC:MED&resulttype=core&format=json

24 December 2019

page(s)

399-415

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18928409 AND SRC:MED&resulttype=core&format=json

Hepatitis C Virus Induces E6AP-Dependent Degradation of the Retinoblastoma Protein

24 December 2019

cites work

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The lipid droplet is an important organelle for hepatitis C virus production

27 July 2018

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TP53 mutations and hepatocellular carcinoma: insights into the etiology and pathogenesis of liver cancer

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Nucleocytoplasmic shuttling of the retinoblastoma tumor suppressor protein via Cdk phosphorylation-dependent nuclear export

27 July 2018

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The contributions of hepatitis B virus and hepatitis C virus infections to cirrhosis and primary liver cancer worldwide

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27 July 2018

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NS3 protein of Hepatitis C virus associates with the tumour suppressor p53 and inhibits its function in an NS3 sequence-dependent manner

27 July 2018

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27 July 2018

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27 July 2018

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Down-regulation of the retinoblastoma tumor suppressor by the hepatitis C virus NS5B RNA-dependent RNA polymerase

27 July 2018

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DDX3, a DEAD box RNA helicase, is deregulated in hepatitis virus-associated hepatocellular carcinoma and is involved in cell growth control

27 July 2018

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27 July 2018

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Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus

27 July 2018

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27 July 2018

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Hepatitis C virus core variants isolated from liver tumor but not from adjacent non-tumor tissue interact with Smad3 and inhibit the TGF-beta pathway

27 July 2018

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27 July 2018

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27 July 2018

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Hepatitis C virus NS5A-mediated activation of phosphoinositide 3-kinase results in stabilization of cellular beta-catenin and stimulation of beta-catenin-responsive transcription

27 July 2018

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Immune evasion by hepatitis C virus NS3/4A protease-mediated cleavage of the Toll-like receptor 3 adaptor protein TRIF

27 July 2018

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The DEAD box protein p68: a novel transcriptional coactivator of the p53 tumour suppressor

27 July 2018

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Hepatitis C virus core protein, cytochrome P450 2E1, and alcohol produce combined mitochondrial injury and cytotoxicity in hepatoma cells.

27 July 2018

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Hepatocellular carcinoma: recent trends in the United States

27 July 2018

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Hepatocellular carcinoma: recent trends in Japan.

27 July 2018

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Mechanisms of human papillomavirus-induced oncogenesis.

27 July 2018

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Hepatitis C viral proteins interact with Smad3 and differentially regulate TGF-beta/Smad3-mediated transcriptional activation

27 July 2018

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Cellular RNA helicase p68 relocalization and interaction with the hepatitis C virus (HCV) NS5B protein and the potential role of p68 in HCV RNA replication

27 July 2018

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Pathophysiology of hepatitis C virus infection and related liver disease

27 July 2018

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Interactions between viral nonstructural proteins and host protein hVAP-33 mediate the formation of hepatitis C virus RNA replication complex on lipid raft

27 July 2018

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Modulation of p53 transcription regulatory activity and post-translational modification by hepatitis C virus core protein

27 July 2018

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Activation of the CKI-CDK-Rb-E2F pathway in full genome hepatitis C virus-expressing cells

27 July 2018

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HCV core, NS3, NS5A and NS5B proteins modulate cell proliferation independently from p53 expression in hepatocarcinoma cell lines.

27 July 2018

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27 July 2018

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27 July 2018

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Human papillomavirus type 16 E7 oncoprotein can induce abnormal centrosome duplication through a mechanism independent of inactivation of retinoblastoma protein family members

27 July 2018

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Regulation of Interferon Regulatory Factor-3 by the Hepatitis C Virus Serine Protease

27 July 2018

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Identification of the Hepatitis C Virus RNA Replication Complex in Huh-7 Cells Harboring Subgenomic Replicons

27 July 2018

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Current therapy for hepatitis C: pegylated interferon and ribavirin

27 July 2018

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Hepatitis C virus NS5A protein binds TBP and p53, inhibiting their DNA binding and p53 interactions with TBP and ERCC3

27 July 2018

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Functional inactivation of pRB results in aneuploid mammalian cells after release from a mitotic block

27 July 2018

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HCV NS5A interacts with p53 and inhibits p53-mediated apoptosis

27 July 2018

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Selectable subgenomic and genome-length dicistronic RNAs derived from an infectious molecular clone of the HCV-N strain of hepatitis C virus replicate efficiently in cultured Huh7 cells

27 July 2018

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Mitochondrial injury, oxidative stress, and antioxidant gene expression are induced by hepatitis C virus core protein

27 July 2018

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Sequences in the 5' nontranslated region of hepatitis C virus required for RNA replication.

27 July 2018

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p53-dependent transcriptional repression of p21(waf1) by hepatitis C virus NS3.

27 July 2018

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27 July 2018

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27 July 2018

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27 July 2018

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Hepatitis C virus NS5A physically associates with p53 and regulates p21/waf1 gene expression in a p53-dependent manner

27 July 2018

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27 July 2018

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Hepatitis C virus core protein enhances p53 function through augmentation of DNA binding affinity and transcriptional ability

27 July 2018

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27 July 2018

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Hepatitis C virus-encoded enzymatic activities and conserved RNA elements in the 3' nontranslated region are essential for virus replication in vivo

27 July 2018

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27 July 2018

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27 July 2018

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The prevalence of hepatitis C virus infection in the United States, 1988 through 1994

27 July 2018

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Antiapoptotic and oncogenic potentials of hepatitis C virus are linked to interferon resistance by viral repression of the PKR protein kinase

27 July 2018

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27 July 2018

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pRB plays an essential role in cell cycle arrest induced by DNA damage

27 July 2018

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The core protein of hepatitis C virus induces hepatocellular carcinoma in transgenic mice

27 July 2018

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Somatic mutations of the beta-catenin gene are frequent in mouse and human hepatocellular carcinomas

27 July 2018

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27 July 2018

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Human Papillomavirus Oncoproteins E6 and E7 Independently Abrogate the Mitotic Spindle Checkpoint

27 July 2018

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Evidence that hepatitis C virus resistance to interferon is mediated through repression of the PKR protein kinase by the nonstructural 5A protein

27 July 2018

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Hepatitis C virus core and E2 protein expression in transgenic mice

27 July 2018

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Alpha interferon treatment may prevent hepatocellular carcinoma in HCV-related liver cirrhosis.

27 July 2018

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Interferon sensitivity determining sequence of the hepatitis C virus genome

27 July 2018

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Alpha interferon suppresses the cyclin D3 and cdc25A genes, leading to a reversible G0-like arrest

27 July 2018

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27 July 2018

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Growth arrest by induction of p53 in DNA damaged keratinocytes is bypassed by human papillomavirus 16 E7.

27 July 2018

1 reference

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A central region in the hepatitis C virus NS4A protein allows formation of an active NS3-NS4A serine proteinase complex in vivo and in vitro

27 July 2018

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p53 controls both the G2/M and the G1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts

27 July 2018

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Randomised trial of effects of interferon-alpha on incidence of hepatocellular carcinoma in chronic active hepatitis C with cirrhosis.

27 July 2018

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Growth of human hepatoma cells lines with differentiated functions in chemically defined medium

27 July 2018

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Cooperation of SV40 large T antigen and the cellular protein p53 in maintenance of cell transformation.

27 July 2018

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Abnormal structure and expression of p53 gene in human hepatocellular carcinoma

27 July 2018

1 reference

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The phosphorylation state of the retinoblastoma (RB) protein in G0/G1 is dependent on growth status

27 July 2018

1 reference

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Internal ribosome entry site within hepatitis C virus RNA

27 July 2018

1 reference

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Interferon regulatory factor-3 activation, hepatic interferon-stimulated gene expression, and immune cell infiltration in hepatitis C virus patients

27 July 2018

1 reference

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Structure and function of the protein kinase R.

26 September 2018

1 reference

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Causes and consequences of mitochondrial reactive oxygen species generation in hepatitis C.

26 September 2018

1 reference

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Hepatic iron overload induces hepatocellular carcinoma in transgenic mice expressing the hepatitis C virus polyprotein

26 September 2018

1 reference

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Increased liver pathology in hepatitis C virus transgenic mice expressing the hepatitis B virus X protein

26 September 2018

1 reference

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On the road to cancer: aneuploidy and the mitotic checkpoint

26 September 2018

1 reference

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Hepatitis C virus core protein inhibits mitochondrial electron transport and increases reactive oxygen species (ROS) production

26 September 2018

1 reference

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Oxidative stress and lipid peroxidation-derived DNA-lesions in inflammation driven carcinogenesis.

26 September 2018

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Rb inactivation promotes genomic instability by uncoupling cell cycle progression from mitotic control.

26 September 2018

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Chronic liver disease mortality in the United States, 1990-1998.

26 September 2018

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Mechanisms of genomic instability in human cancer: insights from studies with human papillomavirus oncoproteins

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4422400

Virus-host cell interactions during hepatitis C virus RNA replication: impact of polyprotein expression on the cellular transcriptome and cell cycle association with viral RNA synthesis

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4422400

The Hepatitis C virus NS5A protein activates a phosphoinositide 3-kinase-dependent survival signaling cascade

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4422400

3' nontranslated RNA signals required for replication of hepatitis C virus RNA

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4422400

Establishment of B-cell lymphoma cell lines persistently infected with hepatitis C virus in vivo and in vitro: the apoptotic effects of virus infection

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4422400

Hepatocellular carcinoma associated with hepatitis C virus infection in Japan: projection to other countries in the foreseeable future

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4422400

Steatosis and liver cancer in transgenic mice expressing the structural and nonstructural proteins of hepatitis C virus

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4422400

Oxidative stress in the absence of inflammation in a mouse model for hepatitis C virus-associated hepatocarcinogenesis

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4422400

Efficient initiation of HCV RNA replication in cell culture

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4422400

Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4422400

Hepatitis C virus NS5A protein modulates cell cycle regulatory genes and promotes cell growth

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4422400

Hepatitis C virus core protein interacts with a human DEAD box protein DDX3

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4422400

Complex formation of the nonstructural protein 3 of hepatitis C virus with the p53 tumor suppressor

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4422400

Hepatocellular proliferation and development of hepatocellular carcinoma: a case-control study in chronic hepatitis C.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4422400

Biochemical and kinetic analyses of NS5B RNA-dependent RNA polymerase of the hepatitis C virus.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4422400

In situ detection of hepatitis B, C, and G virus nucleic acids in human hepatocellular carcinoma tissues from different geographic regions

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4422400

Infection of a chimpanzee with hepatitis C virus grown in cell culture

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4422400

Efficient conditional transgene expression in hepatitis C virus cDNA transgenic mice mediated by the Cre/loxP system

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4422400

The human papillomavirus-16 E6 oncoprotein decreases the vigilance of mitotic checkpoints.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4422400

Transgenic expression of hepatitis C virus structural proteins in the mouse

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4422400

Cell growth arrest and induction of cyclin-dependent kinase inhibitor p21 WAF1/CIP1 mediated by STAT1.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4422400

Hepatitis C virus NS3 protein polynucleotide-stimulated nucleoside triphosphatase and comparison with the related pestivirus and flavivirus enzymes

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4422400

NS3 is a serine protease required for processing of hepatitis C virus polyprotein

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4422400

Epidemiology of Hepatocellular Carcinoma

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4422400

Liver-specific pRB loss results in ectopic cell cycle entry and aberrant ploidy

15 November 2018

1 reference

12 December 2020

Molecular pathogenesis of human hepatocellular carcinoma

1 reference

12 December 2020

Hepatitis C infection and the increasing incidence of hepatocellular carcinoma: a population-based study

1 reference

12 December 2020

The retinoblastoma protein is partially phosphorylated during early G1 in cycling cells but not in G1 cells arrested with alpha-interferon

1 reference

12 December 2020

Disregulation of mitotic checkpoints and regulatory proteins following acute expression of SV40 large T antigen in diploid human cells

1 reference

12 December 2020

10.1146/ANNUREV.PATHOL.4.110807.092202

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18928409 AND SRC:MED&resulttype=core&format=json

24 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18928409 AND SRC:MED&resulttype=core&format=json

24 December 2019

PubMed publication ID

18928409

1 reference