Flexible Cullins in Cullin-RING E3 Ligases Allosterically Regulate Ubiquitination (Q35562631)

8 August 2017

title

Flexible cullins in cullin-RING E3 ligases allosterically regulate ubiquitination (English)

1 reference

8 August 2017

Flexible Cullins in Cullin-RING E3 Ligases Allosterically Regulate Ubiquitination (English)

1 reference

https://api.crossref.org/works/10.1074/JBC.M111.277236

molecular dynamics simulation

12 December 2024

main subject

protein ubiquitination

1 reference

based on heuristic

inferred from title

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:21937436

12 December 2024

2

Ruth Nussinov

1 reference

8 August 2017

Jin Liu

1

0 references

language of work or name

English

0 references

publication date

20 September 2011

1 reference

full work available at URL

8 August 2017

https://europepmc.org/articles/pmc3220518?pdf=render

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:21937436

https://europepmc.org/articles/PMC3220518

12 December 2024

file format

HyperText Markup Language

online access status

open access

content deliverer

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:21937436

https://europepmc.org/articles/PMC3220518?pdf=render

12 December 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:21937436

https://api.elsevier.com/content/article/PII:S0021925820504432?httpAccept=text/xml

12 December 2024

1 reference

https://api.crossref.org/works/10.1074/JBC.M111.277236

https://api.elsevier.com/content/article/PII:S0021925820504432?httpAccept=text/plain

12 December 2024

1 reference

https://api.crossref.org/works/10.1074/JBC.M111.277236

https://syndication.highwire.org/content/doi/10.1074/jbc.M111.277236

12 December 2024

1 reference

https://api.crossref.org/works/10.1074/JBC.M111.277236

Journal of Biological Chemistry

12 December 2024

published in

1 reference

8 August 2017

volume

286

1 reference

8 August 2017

issue

47

1 reference

8 August 2017

page(s)

40934-40942

1 reference

Dynamic allostery: linkers are not merely flexible

8 August 2017

cites work

1 reference

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The cullin protein family

12 July 2018

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Structural regulation of cullin-RING ubiquitin ligase complexes

12 July 2018

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Expanding role of ubiquitination in NF-κB signaling

12 July 2018

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Structural assembly of cullin-RING ubiquitin ligase complexes

12 July 2018

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Molecular insight into the conformational dynamics of the Elongin BC complex and its interaction with HIV-1 Vif.

12 July 2018

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Rbx1 flexible linker facilitates cullin-RING ligase function before neddylation and after deneddylation

12 July 2018

1 reference

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The SOCS-box of HIV-1 Vif interacts with ElonginBC by induced-folding to recruit its Cul5-containing ubiquitin ligase complex

12 July 2018

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Molecular dynamics reveal the essential role of linker motions in the function of cullin-RING E3 ligases

12 July 2018

1 reference

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A promiscuous alpha-helical motif anchors viral hijackers and substrate receptors to the CUL4-DDB1 ubiquitin ligase machinery

12 July 2018

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CRL4s: the CUL4-RING E3 ubiquitin ligases

12 July 2018

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The mechanism of ubiquitination in the cullin-RING E3 ligase machinery: conformational control of substrate orientation

12 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220518

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12 July 2018

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An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

12 July 2018

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Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugation

12 July 2018

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Structural insight into the human immunodeficiency virus Vif SOCS box and its role in human E3 ubiquitin ligase assembly

12 July 2018

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Allosteric effects in the marginally stable von Hippel-Lindau tumor suppressor protein and allostery-based rescue mutant design

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220518

Characterization of Cullin-box sequences that direct recruitment of Cul2-Rbx1 and Cul5-Rbx2 modules to Elongin BC-based ubiquitin ligases

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220518

Structure of the SOCS4-ElonginB/C Complex Reveals a Distinct SOCS Box Interface and the Molecular Basis for SOCS-Dependent EGFR Degradation

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220518

Taking it step by step: mechanistic insights from structural studies of ubiquitin/ubiquitin-like protein modification pathways

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220518

Structure of a Fbw7-Skp1-cyclin E complex: multisite-phosphorylated substrate recognition by SCF ubiquitin ligases

12 July 2018

1 reference

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Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220518

Crystal structure of the SOCS2-elongin C-elongin B complex defines a prototypical SOCS box ubiquitin ligase

12 July 2018

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The SWISS-MODEL workspace: a web-based environment for protein structure homology modelling

12 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220518

Scalable molecular dynamics with NAMD

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220518

Structural basis of the Cks1-dependent recognition of p27(Kip1) by the SCF(Skp2) ubiquitin ligase

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220518

VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases

12 July 2018

1 reference

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Structure of the Cand1-Cul1-Roc1 complex reveals regulatory mechanisms for the assembly of the multisubunit cullin-dependent ubiquitin ligases

12 July 2018

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BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3.

12 July 2018

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Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity of the SCF(beta-TrCP1) ubiquitin ligase

12 July 2018

1 reference

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Structural basis for phosphodependent substrate selection and orientation by the SCFCdc4 ubiquitin ligase

12 July 2018

1 reference

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Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling

12 July 2018

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Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex

12 July 2018

1 reference

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Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases

12 July 2018

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12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220518

VMD: visual molecular dynamics

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220518

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12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220518

PARC and CUL7 form atypical cullin RING ligase complexes

12 July 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M111.277236

Protein domain movements: detection of rigid domains and visualization of hinges in comparisons of atomic coordinates

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220518

Structure of DDB1 in complex with a paramyxovirus V protein: viral hijack of a propeller cluster in ubiquitin ligase

26 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21937436

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

1 reference

8 August 2017

1 reference

8 August 2017

1 reference