Antiplatelet therapy: in search of the 'magic bullet'. (Q35550212)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14526381 AND SRC:MED&resulttype=core&format=json

19 December 2019

review article

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title

Antiplatelet therapy: in search of the 'magic bullet' (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14526381 AND SRC:MED&resulttype=core&format=json

19 December 2019

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14526381 AND SRC:MED&resulttype=core&format=json

19 December 2019

Simone M Schoenwaelder

series ordinal

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14526381 AND SRC:MED&resulttype=core&format=json

19 December 2019

author name string

Shaun P Jackson

series ordinal

1

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8 August 2017

Simone M Schoenwaelder

series ordinal

2

1 reference

8 August 2017

publication date

1 October 2003

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14526381 AND SRC:MED&resulttype=core&format=json

Nature Reviews Drug Discovery

19 December 2019

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14526381 AND SRC:MED&resulttype=core&format=json

19 December 2019

volume

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14526381 AND SRC:MED&resulttype=core&format=json

19 December 2019

issue

10

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14526381 AND SRC:MED&resulttype=core&format=json

19 December 2019

page(s)

775-789

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14526381 AND SRC:MED&resulttype=core&format=json

Are we mortgaging the medical profession?

19 December 2019

cites work

1 reference

Coronary Plaque Disruption

31 March 2020

1 reference

Scientific and therapeutic advances in antiplatelet therapy

31 March 2020

1 reference

Antiplatelet drugs. A comparative review

31 March 2020

1 reference

The role of adenosine 5'-diphosphate receptor blockade in patients with cardiovascular disease

31 March 2020

1 reference

Platelet surface physiology and its importance in pharmacotherapy design and development: the adenosine diphosphate receptor antagonists

31 March 2020

1 reference

The antiplatelet effects of ticlopidine and clopidogrel

31 March 2020

1 reference

Therapeutic potential of cyclic nucleotide phosphodiesterase inhibitors in heart failure

31 March 2020

1 reference

Glycoprotein IIb/IIIa antagonists--from bench to practice

31 March 2020

1 reference

Platelet glycoprotein IIb/IIIa antagonists: pharmacology and clinical developments

31 March 2020

1 reference

Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients

31 March 2020

1 reference

A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). CAPRIE Steering Committee

31 March 2020

1 reference

Platelets in atherothrombosis

31 March 2020

1 reference

GPIIb-IIIa: the responsive integrin

31 March 2020

1 reference

Ligand binding to GPIIb-IIIa: a status report

31 March 2020

1 reference

Platelet glycoprotein IIb/IIIa antagonists. What are the relevant issues concerning their pharmacology and clinical use?

31 March 2020

1 reference

Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation

31 March 2020

1 reference

Dose-finding, safety, and tolerability study of an oral platelet glycoprotein IIb/IIIa inhibitor, lotrafiban, in patients with coronary or cerebral atherosclerotic disease

31 March 2020

1 reference

Increased mortality with oral platelet glycoprotein IIb/IIIa antagonists: a meta-analysis of phase III multicenter randomized trials

31 March 2020

1 reference

Oral platelet glycoprotein IIb/IIIa inhibition

31 March 2020

1 reference

Aspirin, warfarin, or the combination for secondary prevention of coronary events in patients with acute coronary syndromes and prior coronary artery bypass surgery

31 March 2020

1 reference

Department of Veterans Affairs Cooperative Studies Program Clinical Trial comparing combined warfarin and aspirin with aspirin alone in survivors of acute myocardial infarction: primary results of the CHAMP study

31 March 2020

1 reference

Real-time in vivo imaging of platelets, tissue factor and fibrin during arterial thrombus formation in the mouse

31 March 2020

1 reference

Plasma fibronectin promotes thrombus growth and stability in injured arterioles

31 March 2020

1 reference

Dynamics of GPIIb/IIIa-mediated platelet-platelet interactions in platelet adhesion/thrombus formation on collagen in vitro as revealed by videomicroscopy

31 March 2020

1 reference

A revised model of platelet aggregation

31 March 2020

1 reference

Persistence of platelet thrombus formation in arterioles of mice lacking both von Willebrand factor and fibrinogen

31 March 2020

1 reference

A mouse model of severe von Willebrand disease: defects in hemostasis and thrombosis

31 March 2020

1 reference

Variable protection of beta 3-integrin--deficient mice from thrombosis initiated by different mechanisms

31 March 2020

1 reference

Beta3-integrin-deficient mice are a model for Glanzmann thrombasthenia showing placental defects and reduced survival.

31 March 2020

1 reference

Pharmacological characterization and antithrombotic effect of agkistin, a platelet glycoprotein Ib antagonist

31 March 2020

1 reference

Inhibition of Platelet Glycoprotein Ib, Glycoprotein IIb/IIIa, or Both by Monoclonal Antibodies Prevents Arterial Thrombosis in Baboons

31 March 2020

1 reference

Generation and rescue of a murine model of platelet dysfunction: the Bernard-Soulier syndrome

31 March 2020

1 reference

Increased thrombin responsiveness in platelets from mice lacking glycoprotein V

31 March 2020

1 reference

Platelet glycoprotein V binds to collagen and participates in platelet adhesion and aggregation

31 March 2020

1 reference

A crucial role of glycoprotein VI for platelet recruitment to the injured arterial wall in vivo

31 March 2020

1 reference

The contribution of glycoprotein VI to stable platelet adhesion and thrombus formation illustrated by targeted gene deletion

31 March 2020

1 reference

A patient with platelets deficient in glycoprotein VI that lack both collagen-induced aggregation and adhesion

31 March 2020

1 reference

Platelets activated by collagen through immunoreceptor tyrosine-based activation motif play pivotal role in initiation and generation of neointimal hyperplasia after vascular injury

31 March 2020

1 reference

Glycoprotein VI but not alpha2beta1 integrin is essential for platelet interaction with collagen

31 March 2020

1 reference

Human blood platelets showing no response to collagen fail to express surface glycoprotein Ia

31 March 2020

1 reference

Biochemistry and genetics of von Willebrand factor

31 March 2020

1 reference

Resolution of spontaneous bleeding events but failure of pregnancy in fibrinogen-deficient mice

31 March 2020

1 reference

Selectins influence thrombosis in a mouse model of experimental deep venous thrombosis

31 March 2020

1 reference

Accumulation of tissue factor into developing thrombi in vivo is dependent upon microparticle P-selectin glycoprotein ligand 1 and platelet P-selectin

31 March 2020

1 reference

PECAM-1 (CD31) expression modulates bleeding time in vivo

31 March 2020

1 reference

Protection against thrombosis in mice lacking PAR3.

31 March 2020

1 reference

Role of thrombin signalling in platelets in haemostasis and thrombosis

31 March 2020

1 reference

Decreased platelet aggregation, increased bleeding time and resistance to thromboembolism in P2Y1-deficient mice.

31 March 2020

1 reference

Defective platelet aggregation and increased resistance to thrombosis in purinergic P2Y(1) receptor-null mice

31 March 2020

1 reference

Key role of the P2Y(1) receptor in tissue factor-induced thrombin-dependent acute thromboembolism: studies in P2Y(1)-knockout mice and mice treated with a P2Y(1) antagonist

31 March 2020

1 reference

Molecular identification and characterization of the platelet ADP receptor targeted by thienopyridine antithrombotic drugs

31 March 2020

1 reference

Identification of the platelet ADP receptor targeted by antithrombotic drugs

31 March 2020

1 reference

A role of the fast ATP-gated P2X1 cation channel in thrombosis of small arteries in vivo

31 March 2020

1 reference

A natural dominant negative P2X1 receptor due to deletion of a single amino acid residue

31 March 2020

1 reference

Coagulation defects and altered hemodynamic responses in mice lacking receptors for thromboxane A2

31 March 2020

1 reference

Two thromboxane A2 receptor isoforms in human platelets. Opposite coupling to adenylyl cyclase with different sensitivity to Arg60 to Leu mutation

31 March 2020

1 reference

Arg60 to Leu mutation of the human thromboxane A2 receptor in a dominantly inherited bleeding disorder

31 March 2020

1 reference

Increased bleeding tendency and decreased susceptibility to thromboembolism in mice lacking the prostaglandin E receptor subtype EP(3).

31 March 2020

1 reference

Resistance to thromboembolism in PI3Kgamma-deficient mice.

31 March 2020

1 reference

Integrin cytoplasmic tyrosine motif is required for outside-in alphaIIbbeta3 signalling and platelet function

31 March 2020

1 reference

Regulation of blood and lymphatic vascular separation by signaling proteins SLP-76 and Syk.

31 March 2020

1 reference

Fetal hemorrhage and platelet dysfunction in SLP-76-deficient mice.

31 March 2020

1 reference

Hematopoietic reconstitution of SLP-76 corrects hemostasis and platelet signaling through alpha IIb beta 3 and collagen receptors

31 March 2020

1 reference

Phospholipase Cgamma2 is essential in the functions of B cell and several Fc receptors

31 March 2020

1 reference

A PLC gamma 2-independent platelet collagen aggregation requiring functional association of GPVI and integrin alpha2beta1

31 March 2020

1 reference

Increased platelet sensitivity to ADP in mice lacking platelet-type 12-lipoxygenase

31 March 2020

1 reference

Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration.

31 March 2020

1 reference

Impairment of Platelet Thromboxane A2Generation and of the Platelet Release Reaction in Two Patients with Congenital Deficiency of Platelet Cyclo-oxygenase

31 March 2020

1 reference

Physiological role of an endoperoxide in human platelets: hemostatic defect due to platelet cyclo-oxygenase deficiency

31 March 2020

1 reference

Familial and constitutional bleeding disorder due to platelet cyclo-oxygenase deficiency

31 March 2020

1 reference

Defective platelet activation in G alpha(q)-deficient mice.

31 March 2020

1 reference

Increased adhesion and aggregation of platelets lacking cyclic guanosine 3',5'-monophosphate kinase I.

31 March 2020

1 reference

Deficiency or inhibition of Gas6 causes platelet dysfunction and protects mice against thrombosis.

31 March 2020

1 reference

CD40L stabilizes arterial thrombi by a β3 integrin–dependent mechanism

31 March 2020

1 reference

31 March 2020

von Willebrand factor

1 reference

Old concepts and new developments in the study of platelet aggregation

31 March 2020

1 reference

Specific synergy of multiple substrate-receptor interactions in platelet thrombus formation under flow.

31 March 2020

1 reference

Initiation of platelet adhesion by arrest onto fibrinogen or translocation on von Willebrand factor

31 March 2020

1 reference

Fibronectin in platelet adhesion to human collagen types I and III. Use of nonfibrillar and fibrillar collagen in flowing blood studies

31 March 2020

1 reference

Role of factor VIII-von Willebrand factor and fibronectin in the interaction of platelets in flowing blood with monomeric and fibrillar human collagen types I and III.

31 March 2020

1 reference

Fibrinogen-independent platelet adhesion and thrombus formation on subendothelium mediated by glycoprotein IIb-IIIa complex at high shear rate

31 March 2020

1 reference

The role of von Willebrand factor and fibrinogen in platelet aggregation under varying shear stress

31 March 2020

1 reference

Platelet-collagen interaction: is GPVI the central receptor?

31 March 2020

1 reference

Increased platelet deposition on atherosclerotic coronary arteries

31 March 2020

1 reference

Glycoprotein VI is the collagen receptor in platelets which underlies tyrosine phosphorylation of the Fc receptor γ‐chain

31 March 2020

1 reference

A Novel Association of Fc Receptor γ-Chain with Glycoprotein VI and Their Co-expression as a Collagen Receptor in Human Platelets

31 March 2020

1 reference

Expression and function of the mouse collagen receptor glycoprotein VI is strictly dependent on its association with the FcRgamma chain

31 March 2020

1 reference

The Fc receptor gamma-chain is necessary and sufficient to initiate signalling through glycoprotein VI in transfected cells by the snake C-type lectin, convulxin

31 March 2020

1 reference

Involvement of glycoprotein VI in platelet thrombus formation on both collagen and von Willebrand factor surfaces under flow conditions

31 March 2020

1 reference

Long-term antithrombotic protection by in vivo depletion of platelet glycoprotein VI in mice

31 March 2020

1 reference

Signaling events underlying thrombus formation

31 March 2020

1 reference

Dose- and shear rate-dependent effects of heparin on thrombogenesis induced by rabbit aorta subendothelium exposed to flowing human blood.

31 March 2020

1 reference

Thrombin plays a key role in late platelet thrombus growth and/or stability. Effect of a specific thrombin inhibitor on thrombogenesis induced by aortic subendothelium exposed to flowing rabbit blood

31 March 2020

1 reference

Modulation of thrombotic responses in moderately stenosed arteries by cigarette smoking and aspirin ingestion

31 March 2020

1 reference

A perfusion chamber developed to investigate thrombus formation and shear profiles in flowing native human blood at the apex of well-defined stenoses

31 March 2020

1 reference

How the protease thrombin talks to cells

31 March 2020

1 reference

31 March 2020

1 reference

PARticipation in inflammation

31 March 2020

1 reference

Identification, characterization, and inhibition of the platelet ADP receptors

31 March 2020

1 reference

A dual thrombin receptor system for platelet activation

31 March 2020

1 reference

Collagen synthesis in atherosclerosis: too much and not enough

31 March 2020

1 reference

Tissue factor modulates the thrombogenicity of human atherosclerotic plaques.

31 March 2020

1 reference

Local inhibition of tissue factor reduces the thrombogenicity of disrupted human atherosclerotic plaques: effects of tissue factor pathway inhibitor on plaque thrombogenicity under flow conditions.

31 March 2020

1 reference

Athero- and thrombogenic actions of lysophosphatidic acid and sphingosine-1-phosphate

31 March 2020

1 reference

Lysophosphatidic acid mediates the rapid activation of platelets and endothelial cells by mildly oxidized low density lipoprotein and accumulates in human atherosclerotic lesions

31 March 2020

1 reference

Coronary artery injury and the biology of atherosclerosis: inflammation, thrombosis, and stabilization

31 March 2020

1 reference

Shed Membrane Microparticles With Procoagulant Potential in Human Atherosclerotic Plaques

31 March 2020

1 reference

Platelet hyperreactivity and prognosis in survivors of myocardial infarction

31 March 2020

1 reference

Hyperreactive platelets and complications of coronary artery disease

31 March 2020

1 reference

Platelet glycoprotein IIb/IIIa inhibitors reduce mortality in diabetic patients with non-ST-segment-elevation acute coronary syndromes

31 March 2020

1 reference

Important triad in cardiovascular medicine: diabetes, coronary intervention, and platelet glycoprotein IIb/IIIa receptor blockade

31 March 2020

1 reference

The epinephrine-blood platelet connection with special reference to essential hypertension

31 March 2020

1 reference

Changes in cardiovascular risk profile during the cessation of smoking

31 March 2020

1 reference

Age, cardiovascular risk factors and coronary heart disease as determinants of platelet function in men. A multivariate approach

31 March 2020

1 reference

Interactions between dietary fat, fish, and fish oils and their effects on platelet function in men at risk of cardiovascular disease

31 March 2020

1 reference

Platelet polymorphisms in thrombotic disorders

31 March 2020

1 reference

Platelet glycoprotein Ibalpha Kozak polymorphism is associated with an increased risk of ischemic stroke

31 March 2020

1 reference

Glycoprotein Ib polymorphisms influence platelet plug formation under high shear rates

31 March 2020

1 reference

A meta‐analysis of studies on the association of the platelet PlA polymorphism of glycoprotein IIIa and risk of coronary heart disease

31 March 2020

1 reference

Platelet collagen receptors and risk prediction in stroke and coronary artery disease

31 March 2020

1 reference

Numerical investigation of physiologically realistic pulsatile flow through arterial stenosis

31 March 2020

1 reference

Fluid mechanics of vascular systems, diseases, and thrombosis

31 March 2020

1 reference

Experimental and numerical study of pulsatile flows through stenosis: wall shear stress analysis

31 March 2020

1 reference

Knockouts model the 100 best-selling drugs--will they model the next 100?

31 March 2020

1 reference

Recombinant von Willebrand Factor Fragment AR545C Inhibits Platelet Aggregation and Enhances Thrombolysis With rtPA in a Rabbit Thrombosis Model

31 March 2020

1 reference

Anti‐thrombotic effects and bleeding risk of AJvW‐2, a monoclonal antibody against human von Willebrand factor

31 March 2020

1 reference

Anti-human vWF monoclonal antibody, AJvW-2 Fab, inhibits repetitive coronary artery thrombosis without bleeding time prolongation in dogs.

31 March 2020

1 reference

Platelet glycoprotein ibalpha is a counterreceptor for the leukocyte integrin Mac-1 (CD11b/CD18)

31 March 2020

1 reference

The glycoprotein Ib-IX-V complex is a platelet counterreceptor for P-selectin

31 March 2020

1 reference

Inflammation in atherosclerosis

31 March 2020

1 reference

Inflammation and atherosclerosis

31 March 2020

1 reference

Antithrombotic effect of platelet glycoprotein Ib-blocking monoclonal antibody Fab fragments in nonhuman primates.

31 March 2020

1 reference

Inhibition of the von Willebrand (VWF)-collagen interaction by an antihuman VWF monoclonal antibody results in abolition of in vivo arterial platelet thrombus formation in baboons.

31 March 2020

1 reference

Considerable time from the onset of plaque rupture and/or thrombi until the onset of acute myocardial infarction in humans: coronary angiographic findings within 1 week before the onset of infarction

31 March 2020

1 reference

Aspirin selectively inhibits prostaglandin production in human platelets

31 March 2020

1 reference

Inhibition of Vascular and Platelet Prostaglandin Synthesis by Aspirin

31 March 2020

1 reference

Randomized trial of ridogrel, a combined thromboxane A2 synthase inhibitor and thromboxane A2/prostaglandin endoperoxide receptor antagonist, versus aspirin as adjunct to thrombolysis in patients with acute myocardial infarction. The Ridogrel Versus

31 March 2020

1 reference

Terbogrel, a dual-acting agent for thromboxane receptor antagonism and thromboxane synthase inhibition

31 March 2020

1 reference

Guanidine derivatives as combined thromboxane A2 receptor antagonists and synthase inhibitors

31 March 2020

1 reference

Effects of the thromboxane synthetase inhibitor and receptor antagonist terbogrel in patients with primary pulmonary hypertension

31 March 2020

1 reference

Signaling role for phospholipase C gamma 2 in platelet glycoprotein Ib alpha calcium flux and cytoskeletal reorganization. Involvement of a pathway distinct from FcR gamma chain and Fc gamma RIIA.

31 March 2020

1 reference

Platelet-derived CD40L: the switch-hitting player of cardiovascular disease

31 March 2020

1 reference

Aspirin and mortality from coronary bypass surgery

31 March 2020

1 reference

Preventing stroke: is preventing microemboli enough?

31 March 2020

1 reference

Flow cytometric studies of platelet responses to shear stress in whole blood

31 March 2020

1 reference