Purinoceptors as therapeutic targets for lower urinary tract dysfunction (Q35545723)

8 August 2017

1 reference

title

Purinoceptors as therapeutic targets for lower urinary tract dysfunction (English)

1 reference

8 August 2017

Anthony P D W Ford

1

1 reference

8 August 2017

Joel R Gever

2

1 reference

8 August 2017

Philip A Nunn

3

1 reference

8 August 2017

Yu Zhong

4

1 reference

8 August 2017

Joseph S Cefalu

5

1 reference

8 August 2017

Michael P Dillon

6

1 reference

8 August 2017

Debra A Cockayne

7

1 reference

8 August 2017

language of work or name

English

0 references

publication date

1 February 2006

1 reference

British Journal of Pharmacology

8 August 2017

published in

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8 August 2017

volume

147 Suppl 2

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8 August 2017

page(s)

S132-43

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Parallel "pain" pathways arise from subpopulations of primary afferent nociceptor

8 August 2017

cites work

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12 July 2018

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Lower urinary tract symptoms suggestive of benign prostatic hyperplasia: latest update on alpha-adrenoceptor antagonists

12 July 2018

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Pharmacology of the lower urinary tract: basis for current and future treatments of urinary incontinence

12 July 2018

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Investigation of the effects of P2 purinoceptor ligands on the micturition reflex in female urethane-anaesthetized rats

12 July 2018

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Guideline for the primary care management of male lower urinary tract symptoms

12 July 2018

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Molecular recognition at purine and pyrimidine nucleotide (P2) receptors.

12 July 2018

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Darifenacin, an M3 selective receptor antagonist, is an effective and well-tolerated once-daily treatment for overactive bladder

12 July 2018

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siRNA relieves chronic neuropathic pain

12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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Epidemiology of prostatitis: new evidence for a world-wide problem

12 July 2018

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Effectiveness of anticholinergic drugs compared with placebo in the treatment of overactive bladder: systematic review

12 July 2018

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Recommendations for the evaluation of patients with prostatitis

12 July 2018

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Experimental muscle pain and tenderness following infusion of endogenous substances in humans

12 July 2018

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Characterization of the UDP-glucose receptor (re-named here the P2Y14 receptor) adds diversity to the P2Y receptor family

12 July 2018

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A-317491, a novel potent and selective non-nucleotide antagonist of P2X3 and P2X2/3 receptors, reduces chronic inflammatory and neuropathic pain in the rat.

12 July 2018

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Molecular physiology of P2X receptors

12 July 2018

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Analgesic profile of intrathecal P2X(3) antisense oligonucleotide treatment in chronic inflammatory and neuropathic pain states in rats

12 July 2018

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Altered urinary bladder function in mice lacking the vanilloid receptor TRPV1

12 July 2018

1 reference

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Targets for therapy of the painful bladder

12 July 2018

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Targeting afferent hyperexcitability for therapy of the painful bladder syndrome

12 July 2018

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The cellular basis of contraction in human detrusor smooth muscle from patients with stable and unstable bladders

12 July 2018

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Smooth muscle does not have a common P2x receptor phenotype: expression, ontogeny and function of P2x1 receptors in mouse ileum, bladder and reproductive systems

12 July 2018

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P2X3 knock-out mice reveal a major sensory role for urothelially released ATP

12 July 2018

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P2X receptors in peripheral neurons

12 July 2018

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Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

12 July 2018

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The distribution of single P2x1-receptor clusters on smooth muscle cells in relation to nerve varicosities in the rat urinary bladder

12 July 2018

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12 July 2018

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Modulation of BzATP and formalin induced nociception: attenuation by the P2X receptor antagonist, TNP-ATP and enhancement by the P2X(3) allosteric modulator, cibacron blue

12 July 2018

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Pharmacological agents for the treatment of urinary incontinence due to overactive bladder

12 July 2018

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P2X receptor expression in mouse urinary bladder and the requirement of P2X(1) receptors for functional P2X receptor responses in the mouse urinary bladder smooth muscle

12 July 2018

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Warm-coding deficits and aberrant inflammatory pain in mice lacking P2X3 receptors

12 July 2018

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Urinary bladder hyporeflexia and reduced pain-related behaviour in P2X3-deficient mice

12 July 2018

1 reference

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Perisphincteric injection of botulinum toxin type A. A treatment option for patients with chronic prostatic pain?

12 July 2018

1 reference

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ATP in human skin elicits a dose-related pain response which is potentiated under conditions of hyperalgesia.

12 July 2018

1 reference

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Intravesical treatment of overactive bladder

12 July 2018

1 reference

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Muscarinic receptor antagonists in the treatment of overactive bladder

12 July 2018

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Evidence for the involvement of spinal endogenous ATP and P2X receptors in nociceptive responses caused by formalin and capsaicin in mice

12 July 2018

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In vivo pathway of thermal hyperalgesia by intrathecal administration of alpha,beta-methylene ATP in mouse spinal cord: involvement of the glutamate-NMDA receptor system

12 July 2018

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The expression of P2X3 purinoreceptors in sensory neurons: effects of axotomy and glial-derived neurotrophic factor.

12 July 2018

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Evidence for purinergic neurotransmission in the urinary bladder of pithed rats.

12 July 2018

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P2X1 and P2X3 receptors form stable trimers: a novel structural motif of ligand-gated ion channels

12 July 2018

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Immunohistochemical study of the P2X2 and P2X3 receptor subunits in rat and monkey sensory neurons and their central terminals.

12 July 2018

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Chronic abacterial prostatitis--a urological chronic pain syndrome?

12 July 2018

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Functional importance of cholinergic and purinergic neurotransmission for micturition contraction in the normal, unanaesthetized rat

12 July 2018

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PPADS selectively antagonizes P2X-purinoceptor-mediated responses in the rabbit urinary bladder

12 July 2018

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Pharmacology of lower urinary tract smooth muscles and penile erectile tissues.

12 July 2018

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Myelinated primary afferents of the sacral spinal cord responding to slow filling and distension of the cat urinary bladder

12 July 2018

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The pathophysiological changes in the bladder obstructed by benign prostatic hyperplasia

12 July 2018

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Human female bladder and its noncholinergic contractile function.

12 July 2018

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A comparison of spontaneous and nerve-mediated activity in bladder muscle from man, pig and rabbit

12 July 2018

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The use of the slowly degradable analog, alpha, beta-methylene ATP, to produce desensitisation of the P2-purinoceptor: effect on non-adrenergic, non-cholinergic responses of the guinea-pig urinary bladder

12 July 2018

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Atropine Resistance of Transmurally Stimulated Isolated Human Bladder Muscle

12 July 2018

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Neurotransmission in Activation of the Contractile Response in the Human Urinary Bladder

12 July 2018

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12 July 2018

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Antagonism by aspirin and fenamates of bronchoconstriction and nociception induced by adenosine-5'-triphosphate.

12 July 2018

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Atropine blockade of nerve-mediated stimulation of the human detrusor

12 July 2018

1 reference

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Contractile responses of smooth muscle strips from rat and guinea-pig urinary bladder to transmural stimulation: effects of atropine and alpha,beta-methylene ATP.

12 July 2018

1 reference

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Comparative physiology and pharmacology of the cat and rabbit urinary bladder

12 July 2018

1 reference

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Human, pig and guinea-pig bladder smooth muscle cells generate similar inward currents in response to purinoceptor activation

12 July 2018

1 reference

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The properties of the ATP-induced depolarization and current in single cells isolated from the guinea-pig urinary bladder

12 July 2018

1 reference

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The cholinergic and purinergic components of detrusor contractility in a whole rabbit bladder model

12 July 2018

1 reference

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Identification of algogenic substances in human erythrocytes

12 July 2018

1 reference

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Contribution of adrenergic and "purinergic" neurotransmission to contraction in rabbit detrusor

12 July 2018

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Observations on the algogenic actions of adenosine compounds on the human blister base preparation

12 July 2018

1 reference

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Purinergic innervation of the guinea-pig urinary bladder

12 July 2018

1 reference

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Enhanced ATP release from rat bladder urothelium during chronic bladder inflammation: effect of botulinum toxin A.

12 July 2018

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Tamsulosin in the treatment of LUTS/BPH: an Italian multicentre trial

26 September 2018

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A pooled analysis of three phase III studies to investigate the efficacy, tolerability and safety of darifenacin, a muscarinic M3 selective receptor antagonist, in the treatment of overactive bladder

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1751490

Differential responses of bladder lumbosacral and thoracolumbar dorsal root ganglion neurons to purinergic agonists, protons, and capsaicin.

26 September 2018

1 reference

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Randomized, double-blind placebo controlled trial of the once daily antimuscarinic agent solifenacin succinate in patients with overactive bladder

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1751490

Botulinum toxin a has antinociceptive effects in treating interstitial cystitis

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1751490

Botulinum toxin A inhibits ATP release from bladder urothelium after chronic spinal cord injury

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1751490

Alterations in P2X and P2Y purinergic receptor expression in urinary bladder from normal cats and cats with interstitial cystitis.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1751490

P2X3-immunoreactive nerve fibres in neurogenic detrusor overactivity and the effect of intravesical resiniferatoxin.

26 September 2018

1 reference

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Effects of isolectin B4-conjugated saporin, a targeting cytotoxin, on bladder overactivity induced by bladder irritation

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1751490

European experience of 200 cases treated with botulinum-A toxin injections into the detrusor muscle for urinary incontinence due to neurogenic detrusor overactivity

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1751490

Randomized, double-blind placebo- and tolterodine-controlled trial of the once-daily antimuscarinic agent solifenacin in patients with symptomatic overactive bladder

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1751490

Up-regulation of P2X3 receptor during stretch of bladder urothelial cells from patients with interstitial cystitis

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1751490

Effects of A‐317491, a novel and selective P2X3/P2X2/3 receptor antagonist, on neuropathic, inflammatory and chemogenic nociception following intrathecal and intraplantar administration

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1751490

Bladder and cutaneous sensory neurons of the rat express different functional P2X receptors.

26 September 2018

1 reference

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Effects of intravenous and infravesical administration of suramin, terazosin and BMY 7378 on bladder instability in conscious rats with bladder outlet obstruction

26 September 2018

1 reference

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Distinct roles of P2X receptors in modulating glutamate release at different primary sensory synapses in rat spinal cord

26 September 2018

1 reference

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Histological and electrical properties of rat dorsal root ganglion neurons innervating the lower urinary tract.

26 September 2018

1 reference

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Feline interstitial cystitis results in mechanical hypersensitivity and altered ATP release from bladder urothelium

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1751490

Different responses to drugs against overactive bladder in detrusor muscle of pig, guinea pig and mouse

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1751490

Functional downregulation of P2X3 receptor subunit in rat sensory neurons reveals a significant role in chronic neuropathic and inflammatory pain.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1751490

The contractile potency of adenosine triphosphate and ecto-adenosine triphosphatase activity in guinea pig detrusor and detrusor from patients with a stable, unstable or obstructed bladder

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1751490

Intravesical adenosine triphosphate stimulates the micturition reflex in awake, freely moving rats

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1751490

Effects of dimethyl sulphoxide and heparin on stretch-activated ATP release by bladder urothelial cells from patients with interstitial cystitis

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1751490

Effect of doxazosin on stretch-activated adenosine triphosphate release in bladder urothelial cells from patients with benign prostatic hyperplasia

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1751490

ATP responses in human C nociceptors

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1751490

Activation and sensitisation of low and high threshold afferent fibres mediated by P2X receptors in the mouse urinary bladder

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1751490

TNP-ATP, a potent P2X3 receptor antagonist, blocks acetic acid-induced abdominal constriction in mice: comparison with reference analgesics

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1751490

The standardisation of terminology of lower urinary tract function: report from the Standardisation Sub-committee of the International Continence Society.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1751490

P2X receptors and their role in female idiopathic detrusor instability

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1751490

Afferent fibers of the hypogastric nerves are involved in the facilitating effects of chemical bladder irritation in rats

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1751490

Augmented stretch activated adenosine triphosphate release from bladder uroepithelial cells in patients with interstitial cystitis

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1751490

ATP P2X receptor-mediated enhancement of glutamate release and evoked EPSCs in dorsal horn neurons of the rat spinal cord.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1751490

Distribution of P2X(1) and P2X(3) receptors in the rat and human urinary bladder

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1751490

Capsaicin receptor VR1 and ATP-gated ion channel P2X3 in human urinary bladder.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1751490

A quantitative analysis of purinoceptor expression in human fetal and adult bladders

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1751490

Purine-mediated signalling in pain and visceral perception

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1751490

Purinergic sensory neurotransmission in the urinary bladder: an in vitro study in the rat.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1751490

A comparison of the mode of action of ATP and carbachol on isolated human detrusor smooth muscle.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1751490

A quantitative study of atropine-resistant contractile responses in human detrusor smooth muscle, from stable, unstable and obstructed bladders

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1751490

Increased excitability of afferent neurons innervating rat urinary bladder after chronic bladder inflammation

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1751490

Developmental and injury induced plasticity in the micturition reflex pathway.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1751490

Evidence of adenosine 5'-triphosphate release from nerve and P2x-purinoceptor mediated contraction during electrical stimulation of rat urinary bladder smooth muscle

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1751490

Atropine-resistant excitatory junction potentials in rabbit bladder are blocked by alpha,beta-methylene ATP.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1751490

The effects of some possible inhibitors of ectonucleotidases on the breakdown and pharmacological effects of ATP in the guinea-pig urinary bladder

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1751490

Distribution of P2X receptors in the urinary bladder and the ureter of the rat

26 September 2018

1 reference

12 December 2020

A-317491, a selective P2X3/P2X2/3 receptor antagonist, reverses inflammatory mechanical hyperalgesia through action at peripheral receptors in rats

1 reference

12 December 2020

Prevalence and incidence of interstitial cystitis in a managed care population

1 reference

12 December 2020

A small molecule-kinase interaction map for clinical kinase inhibitors

1 reference

12 December 2020

Activation of unmyelinated afferent fibres by mechanical stimuli and inflammation of the urinary bladder in the cat

1 reference

12 December 2020

Evidence for adenosine triphosphate as an excitatory transmitter in guinea-pig, rabbit and pig urinary bladder

1 reference

12 December 2020

Response of the in vitro whole bladder (rabbit) preparation to autonomic agonists

1 reference

12 December 2020

Evidence for purinergic neurotransmission in human urinary bladder affected by interstitial cystitis

1 reference

12 December 2020

The influence of age on isometric and isotonic rat detrusor contractions

1 reference

12 December 2020

Epidemiology of interstitial cystitis

1 reference

12 December 2020

The ecto-ATPase inhibitor ARL 67156 enhances parasympathetic neurotransmission in the guinea-pig urinary bladder

1 reference

12 December 2020

Activation of ATP P2X receptors elicits glutamate release from sensory neuron synapses

1 reference

12 December 2020

Purinergic Modulation of Rat Urinary Bladder Detrusor Smooth Muscle

1 reference

12 December 2020

ATP is released from rabbit urinary bladder epithelial cells by hydrostatic pressure changes–possible sensory mechanism?

1 reference

12 December 2020

P2X3 is expressed by DRG neurons that terminate in inner lamina II

1 reference

12 December 2020

Identifiers

DOI

10.1038/SJ.BJP.0706637

1 reference

8 August 2017

1 reference

8 August 2017

1 reference