Infectious prion protein alters manganese transport and neurotoxicity in a cell culture model of prion disease (Q35499246)

8 August 2017

title

Infectious prion protein alters manganese transport and neurotoxicity in a cell culture model of prion disease (English)

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8 August 2017

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Dustin P Martin

1

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8 August 2017

Vellareddy Anantharam

2

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8 August 2017

Huajun Jin

3

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8 August 2017

Travis Witte

4

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8 August 2017

Robert Houk

5

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8 August 2017

Arthi Kanthasamy

6

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8 August 2017

Anumantha G Kanthasamy

7

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8 August 2017

language of work or name

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19 August 2011

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8 August 2017

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8 August 2017

volume

32

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8 August 2017

issue

5

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8 August 2017

page(s)

554-562

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The inflammatory footprints of alcohol-induced oxidative damage in neurovascular components

8 August 2017

cites work

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Manganese upregulates cellular prion protein and contributes to altered stabilization and proteolysis: relevance to role of metals in pathogenesis of prion disease

12 July 2018

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Ferroportin is a manganese-responsive protein that decreases manganese cytotoxicity and accumulation

12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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Opposing roles of prion protein in oxidative stress- and ER stress-induced apoptotic signaling

12 July 2018

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Raman optical activity and circular dichroism reveal dramatic differences in the influence of divalent copper and manganese ions on prion protein folding.

12 July 2018

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12 July 2018

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Prion strain discrimination in cell culture: the cell panel assay

12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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Modulation of proteinase K-resistant prion protein in cells and infectious brain homogenate by redox iron: implications for prion replication and disease pathogenesis

12 July 2018

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Normal cellular prion protein protects against manganese-induced oxidative stress and apoptotic cell death

12 July 2018

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Human prion proteins with pathogenic mutations share common conformational changes resulting in enhanced binding to glycosaminoglycans

12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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Interaction of metals with prion protein: possible role of divalent cations in the pathogenesis of prion diseases

12 July 2018

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Comparison of mammalian cell lines expressing distinct isoforms of divalent metal transporter 1 in a tetracycline-regulated fashion

12 July 2018

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The crucial role of metal ions in neurodegeneration: the basis for a promising therapeutic strategy

12 July 2018

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Increased susceptibility to oxidative stress in scrapie-infected neuroblastoma cells is associated with intracellular iron status

12 July 2018

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Molecular neurology of prion disease

12 July 2018

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Potential occupational risks for neurodegenerative diseases

12 July 2018

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Increased iron-induced oxidative stress and toxicity in scrapie-infected neuroblastoma cells

12 July 2018

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12 July 2018

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Manganese toxicity upon overexposure

12 July 2018

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Protein kinase Cdelta is a key downstream mediator of manganese-induced apoptosis in dopaminergic neuronal cells.

12 July 2018

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Exosomes: a bubble ride for prions?

12 July 2018

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Molecular pathways to neurodegeneration

12 July 2018

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Manganese-induced cytotoxicity in dopamine-producing cells

12 July 2018

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Preferential Cu2 coordination by His96 and His111 induces beta-sheet formation in the unstructured amyloidogenic region of the prion protein

12 July 2018

1 reference

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Micellar environments induce structuring of the N-terminal tail of the prion protein.

12 July 2018

1 reference

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PrPc on the road: trafficking of the cellular prion protein

12 July 2018

1 reference

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Prion protein suppresses perturbation of cellular copper homeostasis under oxidative conditions.

12 July 2018

1 reference

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CNS pathogenesis of prion diseases

12 July 2018

1 reference

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Caspase‐3 dependent proteolytic activation of protein kinase Cδ mediates and regulates 1‐methyl‐4‐phenylpyridinium (MPP )‐induced apoptotic cell death in dopaminergic cells: relevance to oxidative stress in dopaminergic degeneration

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3205977

Trafficking of prion proteins through a caveolae-mediated endosomal pathway

12 July 2018

1 reference

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Stability and Cu(II) binding of prion protein variants related to inherited human prion diseases

12 July 2018

1 reference

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Effects of manganese on oxidative stress in CATH.a cells

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3205977

Mechanisms of manganese-induced rat pheochromocytoma (PC12) cell death and cell differentiation

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3205977

Mayhem of the multiple mechanisms: modelling neurodegeneration in prion disease

12 July 2018

1 reference

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Cellular prion protein transduces neuroprotective signals

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3205977

Caspase-3-dependent proteolytic cleavage of protein kinase Cdelta is essential for oxidative stress-mediated dopaminergic cell death after exposure to methylcyclopentadienyl manganese tricarbonyl.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3205977

Metal imbalance and compromised antioxidant function are early changes in prion disease

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3205977

Location and properties of metal-binding sites on the human prion protein.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3205977

Prion diseases of humans and animals: their causes and molecular basis

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3205977

Antioxidant activity related to copper binding of native prion protein

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3205977

Prion infection impairs the cellular response to oxidative stress

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3205977

Consequences of manganese replacement of copper for prion protein function and proteinase resistance

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3205977

Normal prion protein has an activity like that of superoxide dismutase.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3205977

Peripheral biomarkers and exposure to manganese.

12 July 2018

1 reference

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Manganese uptake and distribution in the central nervous system (CNS).

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3205977

Redox metals and neurodegenerative disease

12 July 2018

1 reference

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Copper binding to the prion protein: structural implications of four identical cooperative binding sites

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3205977

Copper stimulates endocytosis of the prion protein

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3205977

Prion disease associated with a novel nine octapeptide repeat insertion in the PRNP gene.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3205977

Mutations and polymorphisms in the prion protein gene

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3205977

Scrapie PrP 27-30 is a sialoglycoprotein

12 July 2018

1 reference

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Prions--infectious pathogens causing the spongiform encephalopathies.

12 July 2018

1 reference

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Prion diseases of the central nervous system

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3205977

Transgenetic studies implicate interactions between homologous PrP isoforms in scrapie prion replication.

12 July 2018

1 reference

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Molecular biology of prion diseases

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3205977

Elemental speciation by liquid chromatography-inductively coupled plasma mass spectrometry with direct injection nebulization

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3205977

Insertion in prion protein gene in familial Creutzfeldt-Jakob disease

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3205977

Structural characterization of the intra- and inter-repeat copper binding modes within the N-terminal region of "prion related protein" (PrP-rel-2) of zebrafish

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3205977

Elevated manganese levels in blood and central nervous system occur before onset of clinical signs in scrapie and bovine spongiform encephalopathy

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3205977

Copper is required for prion protein-associated superoxide dismutase-I activity in Pichia pastoris.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3205977

Oxidative stress in the brain at early preclinical stages of mouse scrapie

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3205977

Hydrogen peroxide cleavage of the prion protein generates a fragment able to initiate polymerisation of full length prion protein.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3205977

Oxidation, glycoxidation, lipoxidation, nitration, and responses to oxidative stress in the cerebral cortex in Creutzfeldt-Jakob disease

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3205977

Increased manganese uptake by primary astrocyte cultures with altered iron status is mediated primarily by divalent metal transporter

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3205977

Redox metals and oxidative abnormalities in human prion diseases

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3205977

Effect of transition metals (Mn, Cu, Fe) and deoxycholic acid (DA) on the conversion of PrPC to PrPres

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3205977

Probing copper2 binding to the prion protein using diamagnetic nickel2 and 1H NMR: the unstructured N terminus facilitates the coordination of six copper2 ions at physiological concentrations

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3205977

Activation of protein kinase C delta by proteolytic cleavage contributes to manganese-induced apoptosis in dopaminergic cells: protective role of Bcl-2.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3205977

Copper and zinc cause delivery of the prion protein from the plasma membrane to a subset of early endosomes and the Golgi

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3205977

Prion protein as trans-interacting partner for neurons is involved in neurite outgrowth and neuronal survival

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3205977

Essential role of the prion protein N terminus in subcellular trafficking and half-life of cellular prion protein.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3205977

Iron: a pathological mediator of Alzheimer disease?

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3205977

PrP-dependent cell adhesion in N2a neuroblastoma cells.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3205977

Oxidative impairment in scrapie-infected mice is associated with brain metals perturbations and altered antioxidant activities

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3205977

Aberrant metal binding by prion protein in human prion disease.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3205977

Ablation of the metal ion-induced endocytosis of the prion protein by disease-associated mutation of the octarepeat region

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3205977

Local structural plasticity of the prion protein. Analysis of NMR relaxation dynamics

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3205977

Alteration of free radical metabolism in the brain of mice infected with scrapie agent

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3205977

Copper binding to the N-terminal tandem repeat regions of mammalian and avian prion protein.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3205977

Elevated manganese levels in blood and CNS in human prion disease

26 September 2018

1 reference

12 December 2020

Manganese binding to the prion protein

1 reference

12 December 2020

Effect of metal ions on de novo aggregation of full-length prion protein

1 reference

12 December 2020

1 reference

12 December 2020

Copper(II) Interaction with Unstructured Prion Domain Outside the Octarepeat Region: Speciation, Stability, and Binding Details of Copper(II) Complexes with PrP106−126 Peptides

1 reference

12 December 2020

Prion protein does not redox-silence Cu2 , but is a sacrificial quencher of hydroxyl radicals

1 reference

12 December 2020

10.1016/J.NEURO.2011.07.008

Identifiers

DOI

1 reference

8 August 2017

1 reference

8 August 2017

1 reference