New small molecules, ISA27 and SM13, inhibit tumour growth inducing mitochondrial effects of p53 (Q35448347)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25422906 AND SRC:MED&resulttype=core&format=json

23 February 2020

title

New small molecules, ISA27 and SM13, inhibit tumour growth inducing mitochondrial effects of p53 (English)

1 reference

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23 February 2020

4

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23 February 2020

Pietro Campiglia

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25422906 AND SRC:MED&resulttype=core&format=json

23 February 2020

Ettore Novellino

7

1 reference

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23 February 2020

Bruno Trimarco

9

1 reference

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23 February 2020

Nicola De Luca

10

1 reference

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23 February 2020

author name string

D Sorriento

1

1 reference

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23 February 2020

C Del Giudice

2

1 reference

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23 February 2020

A Bertamino

3

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23 February 2020

I Gomez-Monterrey

5

1 reference

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23 February 2020

M Illario

8

1 reference

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23 February 2020

G Iaccarino

11

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23 February 2020

language of work or name

English

0 references

publication date

25 November 2014

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25422906 AND SRC:MED&resulttype=core&format=json

British Journal of Cancer

23 February 2020

published in

1 reference

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23 February 2020

volume

112

1 reference

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23 February 2020

issue

1

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23 February 2020

page(s)

77-85

1 reference

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Human glioblastoma multiforme: p53 reactivation by a novel MDM2 inhibitor

23 February 2020

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Synthesis, in vitro, and in cell studies of a new series of [indoline-3,2'-thiazolidine]-based p53 modulators

12 July 2018

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Dual-site interactions of p53 protein transactivation domain with anti-apoptotic Bcl-2 family proteins reveal a highly convergent mechanism of divergent p53 pathways

12 July 2018

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CaMK4 Gene Deletion Induces Hypertension

12 July 2018

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Evaluation of the anti-angiogenic properties of the new selective αVβ3 integrin antagonist RGDechiHCit

12 July 2018

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Identification of the spiro(oxindole-3,3'-thiazolidine)-based derivatives as potential p53 activity modulators

12 July 2018

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Awakening guardian angels: drugging the p53 pathway

12 July 2018

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A new synthetic protein, TAT-RH, inhibits tumor growth through the regulation of NFkappaB activity.

12 July 2018

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Transcription-independent p53 apoptosis: an alternative route to death

12 July 2018

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Cytoplasmic functions of the tumour suppressor p53.

12 July 2018

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The G-protein-coupled receptor kinase 5 inhibits NFkappaB transcriptional activity by inducing nuclear accumulation of IkappaB alpha

12 July 2018

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Small-molecule inhibitors of the MDM2-p53 protein-protein interaction to reactivate p53 function: a novel approach for cancer therapy

12 July 2018

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Transcriptional control of human p53-regulated genes

12 July 2018

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p53 family proteins in thyroid cancer.

12 July 2018

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Mitochondrial membrane permeabilization in cell death

12 July 2018

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p53 isoforms can regulate p53 transcriptional activity.

12 July 2018

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p53 translocation to mitochondria precedes its nuclear translocation and targets mitochondrial oxidative defense protein-manganese superoxide dismutase

12 July 2018

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Transcriptional blockade induces p53-dependent apoptosis associated with translocation of p53 to mitochondria.

12 July 2018

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The C terminus of p53 family proteins is a cell fate determinant

12 July 2018

1 reference

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The common and distinct target genes of the p53 family transcription factors

12 July 2018

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The MDM2-p53 interaction.

12 July 2018

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p53 has a direct apoptogenic role at the mitochondria

12 July 2018

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Live or let die: the cell's response to p53

12 July 2018

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Effects of p53-expressing adenovirus on the chemosensitivity and differentiation of anaplastic thyroid cancer cells

12 July 2018

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Differential Regulation of the p21/WAF-1 and mdm2 Genes after High-Dose UV Irradiation: p53-Dependent and p53-Independent Regulation of the mdm2 Gene

12 July 2018

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Mdm2 promotes the rapid degradation of p53

12 July 2018

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p53, the cellular gatekeeper for growth and division

12 July 2018

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mdm-2 inhibits the G1 arrest and apoptosis functions of the p53 tumor suppressor protein

12 July 2018

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The mdm-2 oncogene can overcome wild-type p53 suppression of transformed cell growth

12 July 2018

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Radiation-induced G1 arrest is selectively mediated by the p53-WAF1/Cip1 pathway in human thyroid cells

12 July 2018

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Major deletions in the gene encoding the p53 tumor antigen cause lack of p53 expression in HL-60 cells

12 July 2018

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The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

12 July 2018

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Impaired neoangiogenesis in β₂-adrenoceptor gene-deficient mice: restoration by intravascular human β₂-adrenoceptor gene transfer and role of NFκB and CREB transcription factors

12 July 2018

1 reference

https://api.crossref.org/works/10.1038/BJC.2014.577

Insulin-like growth factor-1 protects from vascular stenosis and accelerates re-endothelialization in a rat model of carotid artery injury.

21 January 2018

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The MDM2 RING-finger domain is required to promote p53 nuclear export

21 January 2018

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Endothelial cells are able to synthesize and release catecholamines both in vitro and in vivo.

21 January 2018

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p53-independent activation of the hdm2-P2 promoter through multiple transcription factor response elements results in elevated hdm2 expression in estrogen receptor alpha-positive breast cancer cells.

21 January 2018

1 reference

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β2-Adrenergic receptor polymorphisms and treatment-induced regression of left ventricular hypertrophy in hypertension

26 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25422906

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

P53 mediates ceramide-induced apoptosis in SKN-SH cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25422906

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Lack of correlation between p53-dependent transcriptional activity and the ability to induce apoptosis among 179 mutant p53s

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25422906

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/BJC.2014.577

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25422906 AND SRC:MED&resulttype=core&format=json

23 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25422906 AND SRC:MED&resulttype=core&format=json

23 February 2020

PubMed publication ID

25422906

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25422906 AND SRC:MED&resulttype=core&format=json