Discovery of isoxazole analogues of sazetidine-A as selective α4β2-nicotinic acetylcholine receptor partial agonists for the treatment of depression (Q35402036)

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English	Discovery of isoxazole analogues of sazetidine-A as selective α4β2-nicotinic acetylcholine receptor partial agonists for the treatment of depression	scientific article

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12 February 2020

Discovery of isoxazole analogues of sazetidine-A as selective α4β2-nicotinic acetylcholine receptor partial agonists for the treatment of depression (English)

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12 February 2020

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12 February 2020

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Li-Fang Yu

2

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12 February 2020

J Brek Eaton

3

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12 February 2020

Barbara Caldarone

4

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12 February 2020

Katie Cavino

5

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12 February 2020

Christina Ruiz

6

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12 February 2020

Matthew Terry

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12 February 2020

Allison Fedolak

8

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12 February 2020

Daguang Wang

9

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12 February 2020

Afshin Ghavami

10

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12 February 2020

David A Lowe

11

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12 February 2020

Dani Brunner

12

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12 February 2020

Ronald J Lukas

13

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12 February 2020

Alan P Kozikowski

14

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12 February 2020

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30 September 2011

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12 February 2020

Journal of Medicinal Chemistry

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12 February 2020

54

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12 February 2020

20

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12 February 2020

7280-7288

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12 February 2020

Dissociation between duration of action in the forced swim test in mice and nicotinic acetylcholine receptor occupancy with sazetidine, varenicline, and 5-I-A85380.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3197876

12 July 2018

Chemistry and pharmacological characterization of novel nitrogen analogues of AMOP-H-OH (Sazetidine-A, 6-[5-(azetidin-2-ylmethoxy)pyridin-3-yl]hex-5-yn-1-ol) as α4β2-nicotinic acetylcholine receptor-selective partial agonists.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3197876

12 July 2018

The high-affinity nAChR partial agonists varenicline and sazetidine-A exhibit reinforcing properties in rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3197876

12 July 2018

Antidepressant-induced suicidality: an update.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3197876

12 July 2018

Nicotinic partial agonists varenicline and sazetidine-A have differential effects on affective behavior.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3197876

12 July 2018

Rational design of 5-phenyl-3-isoxazolecarboxylic acid ethyl esters as growth inhibitors of Mycobacterium tuberculosis. a potent and selective series for further drug development

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12 July 2018

Chemistry and pharmacology of nicotinic ligands based on 6-[5-(azetidin-2-ylmethoxy)pyridin-3-yl]hex-5-yn-1-ol (AMOP-H-OH) for possible use in depression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3197876

12 July 2018

Structural and functional diversity of native brain neuronal nicotinic receptors

1 reference

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Isoxazole moiety in the linker region of HDAC inhibitors adjacent to the Zn-chelating group: effects on HDAC biology and antiproliferative activity

1 reference

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12 July 2018

Sazetidine-A is a potent and selective agonist at native and recombinant alpha 4 beta 2 nicotinic acetylcholine receptors

1 reference

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Epigenetic targets of HDAC inhibition in neurodegenerative and psychiatric disorders.

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Central nicotinic receptors: structure, function, ligands, and therapeutic potential.

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The nicotinic antagonist mecamylamine has antidepressant-like effects in wild-type but not beta2- or alpha7-nicotinic acetylcholine receptor subunit knockout mice

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12 July 2018

Sazetidine-A, a novel ligand that desensitizes alpha4beta2 nicotinic acetylcholine receptors without activating them

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Therapeutic targets: progress of their exploration and investigation of their characteristics.

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New approaches to antidepressant drug discovery: beyond monoamines

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Characterization of human alpha 4 beta 2-nicotinic acetylcholine receptors stably and heterologously expressed in native nicotinic receptor-null SH-EP1 human epithelial cells

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Nicotinic acetylcholine receptors as targets for antidepressants.

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Abnormal avoidance learning in mice lacking functional high-affinity nicotine receptor in the brain

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Behavioral despair in mice: a primary screening test for antidepressants

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Isoxazolyl-serine-based agonists of peroxisome proliferator-activated receptor: design, synthesis, and effects on cardiomyocyte differentiation

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Mechanism of action of A-85380 in an animal model of depression

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12 December 2020

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Characterization of Nicotinic Acetylcholine Receptors Expressed by Cells of the SH-SY5Y Human Neuroblastoma Clonal Line

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https://pubmed.ncbi.nlm.nih.gov/21905669

12 December 2020

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10.1021/JM200855B

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12 February 2020

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12 February 2020

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12 February 2020

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