BMPR2 preserves mitochondrial function and DNA during reoxygenation to promote endothelial cell survival and reverse pulmonary hypertension (Q35376926)

25863249

8 August 2017

title

BMPR2 preserves mitochondrial function and DNA during reoxygenation to promote endothelial cell survival and reverse pulmonary hypertension (English)

1 reference

8 August 2017

0 references

pulmonary hypertension

1 reference

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25863249 AND SRC:MED&resulttype=core&format=json

9 June 2020

B J Feldman

15

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Miguel A Alejandre Alcazar

9 June 2020

object named as

Miguel A Alejandre Alcazar

12

1 reference

ORCID Public Data File 2021

Kiichi Nakahira

11

object named as

Kiichi Nakahira

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9 June 2020

author name string

Isabel Diebold

1

1 reference

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9 June 2020

Kazuya Miyagawa

3

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9 June 2020

Caiyun G Li

4

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9 June 2020

Nils P Nickel

5

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9 June 2020

Mark Kaschwich

6

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Aiqin Cao

7

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9 June 2020

Lingli Wang

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9 June 2020

Sushma Reddy

9

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9 June 2020

Pin-I Chen

10

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9 June 2020

Rachel K Hopper

13

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Lijuan Ji

14

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9 June 2020

Marlene Rabinovitch

16

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9 June 2020

language of work or name

1 reference

1 April 2015

1 reference

8 August 2017

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9 June 2020

volume

21

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9 June 2020

issue

4

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9 June 2020

page(s)

596-608

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Pulmonary microvascular albumin leak is associated with endothelial cell death in murine sepsis-induced lung injury in vivo

9 June 2020

cites work

1 reference

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The metabolic basis of pulmonary arterial hypertension

27 July 2018

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Reduced BMPR2 expression induces GM-CSF translation and macrophage recruitment in humans and mice to exacerbate pulmonary hypertension

27 July 2018

1 reference

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Mitochondrial transcription factor A, an endogenous danger signal, promotes TNFα release via RAGE- and TLR9-responsive plasmacytoid dendritic cells

27 July 2018

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Interaction of Sirt3 with OGG1 contributes to repair of mitochondrial DNA and protects from apoptotic cell death under oxidative stress.

27 July 2018

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FK506 activates BMPR2, rescues endothelial dysfunction, and reverses pulmonary hypertension.

27 July 2018

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Uncoupling protein 2 impacts endothelial phenotype via p53-mediated control of mitochondrial dynamics

27 July 2018

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Hyperoxia synergizes with mutant bone morphogenic protein receptor 2 to cause metabolic stress, oxidant injury, and pulmonary hypertension.

27 July 2018

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Activation of lung p53 by Nutlin-3a prevents and reverses experimental pulmonary hypertension

27 July 2018

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PGC1α-mediated mitofusin-2 deficiency in female rats and humans with pulmonary arterial hypertension

27 July 2018

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An endothelial apelin-FGF link mediated by miR-424 and miR-503 is disrupted in pulmonary arterial hypertension

27 July 2018

1 reference

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p53 orchestrates the PGC-1α-mediated antioxidant response upon mild redox and metabolic imbalance

27 July 2018

1 reference

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p53-PGC-1α pathway mediates oxidative mitochondrial damage and cardiomyocyte necrosis induced by monoamine oxidase-A upregulation: role in chronic left ventricular dysfunction in mice

27 July 2018

1 reference

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Mitochondrial fission in endothelial cells after simulated ischemia/reperfusion: role of nitric oxide and reactive oxygen species

27 July 2018

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Oxidative Injury is a Common Consequence of BMPR2 Mutations

27 July 2018

1 reference

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Disruption of PPARγ/β-catenin-mediated regulation of apelin impairs BMP-induced mouse and human pulmonary arterial EC survival

27 July 2018

1 reference

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Emergence of Fibroblasts with a Proinflammatory Epigenetically Altered Phenotype in Severe Hypoxic Pulmonary Hypertension

27 July 2018

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Neutrophil Elastase Is Produced by Pulmonary Artery Smooth Muscle Cells and Is Linked to Neointimal Lesions

27 July 2018

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PKCζ mediates disturbed flow-induced endothelial apoptosis via p53 SUMOylation

27 July 2018

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Mitochondria in innate immune responses

27 July 2018

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PGC-1 Coactivators in Cardiac Development and Disease

27 July 2018

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Validation of high-resolution echocardiography and magnetic resonance imaging vs. high-fidelity catheterization in experimental pulmonary hypertension.

27 July 2018

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Endothelial cells and pulmonary arterial hypertension: apoptosis, proliferation, interaction and transdifferentiation

27 July 2018

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Apelin signaling antagonizes Ang II effects in mouse models of atherosclerosis

27 July 2018

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An antiproliferative BMP-2/PPARgamma/apoE axis in human and murine SMCs and its role in pulmonary hypertension

27 July 2018

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Mitochondrial metabolism, redox signaling, and fusion: a mitochondria-ROS-HIF-1alpha-Kv1.5 O2-sensing pathway at the intersection of pulmonary hypertension and cancer

27 July 2018

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Alterations of cellular bioenergetics in pulmonary artery endothelial cells

27 July 2018

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Proteolytic processing of OPA1 links mitochondrial dysfunction to alterations in mitochondrial morphology

27 July 2018

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An abnormal mitochondrial-hypoxia inducible factor-1alpha-Kv channel pathway disrupts oxygen sensing and triggers pulmonary arterial hypertension in fawn hooded rats: similarities to human pulmonary arterial hypertension

27 July 2018

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27 July 2018

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Dichloroacetate prevents and reverses pulmonary hypertension by inducing pulmonary artery smooth muscle cell apoptosis

27 July 2018

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27 July 2018

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27 July 2018

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27 July 2018

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27 July 2018

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27 July 2018

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27 July 2018

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27 July 2018

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Impaired angiogenesis and peripheral muscle microcirculation loss contribute to exercise intolerance in pulmonary arterial hypertension.

27 July 2018

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26 September 2018

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Enhancement of CCL15 expression and monocyte adhesion to endothelial cells (ECs) after hypoxia/reoxygenation and induction of ICAM-1 expression by CCL15 via the JAK2/STAT3 pathway in ECs.

26 September 2018

1 reference

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High occurrence of hypoxemic sleep respiratory disorders in precapillary pulmonary hypertension and mechanisms

26 September 2018

1 reference

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Attenuation of leukocyte recruitment via CXCR1/2 inhibition stops the progression of PAH in mice with genetic ablation of endothelial BMPR-II

26 September 2018

1 reference

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Pyruvate dehydrogenase inhibition by the inflammatory cytokine TNFα contributes to the pathogenesis of pulmonary arterial hypertension

26 September 2018

1 reference

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The mitochondrial DNA 4,977-bp deletion and its implication in copy number alteration in colorectal cancer.

26 September 2018

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Fatty acid oxidation and malonyl-CoA decarboxylase in the vascular remodeling of pulmonary hypertension

26 September 2018

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Epigenetic attenuation of mitochondrial superoxide dismutase 2 in pulmonary arterial hypertension: a basis for excessive cell proliferation and a new therapeutic target.

26 September 2018

1 reference

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Circulating mitochondrial DAMPs cause inflammatory responses to injury

26 September 2018

1 reference

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Hypoxia inducible-factor1alpha regulates the metabolic shift of pulmonary hypertensive endothelial cells

26 September 2018

1 reference

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Tie2-mediated loss of peroxisome proliferator-activated receptor-gamma in mice causes PDGF receptor-beta-dependent pulmonary arterial muscularization.

26 September 2018

1 reference

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Phosphodiesterase 2 mediates redox-sensitive endothelial cell proliferation and angiogenesis by thrombin via Rac1 and NADPH oxidase 2.

26 September 2018

1 reference

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Bone morphogenetic protein receptor-2 signaling promotes pulmonary arterial endothelial cell survival: implications for loss-of-function mutations in the pathogenesis of pulmonary hypertension.

26 September 2018

1 reference

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Diversity in mitochondrial function explains differences in vascular oxygen sensing

26 September 2018

1 reference

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Primary pulmonary hypertension is associated with reduced pulmonary vascular expression of type II bone morphogenetic protein receptor

26 September 2018

1 reference

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Germline mutations of the gene encoding bone morphogenetic protein receptor 1A in juvenile polyposis.

26 September 2018

1 reference

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Heterozygous germline mutations in BMPR2, encoding a TGF-beta receptor, cause familial primary pulmonary hypertension

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394191

Upregulation of Postbacteremic TNF- α and IL-1 α Gene Expression by Alveolar Hypoxia/Reoxygenation in Perfused Rat Lungs

26 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25863249

12 December 2020

inferred from PubMed ID database lookup

Hyperproliferative apoptosis-resistant endothelial cells in idiopathic pulmonary arterial hypertension

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25863249

12 December 2020

inferred from PubMed ID database lookup

p53 Gene deficiency promotes hypoxia-induced pulmonary hypertension and vascular remodeling in mice

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25863249

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1016/J.CMET.2015.03.010

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25863249 AND SRC:MED&resulttype=core&format=json

release_g6dp6esg7vcz3pizzy74gv3jfm

9 June 2020

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/g6dp6esg7vcz3pizzy74gv3jfm

24 November 2022

mapped directly with Wikidata item

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25863249 AND SRC:MED&resulttype=core&format=json

9 June 2020

25863249

1 reference