Hemizygous Le-Cre transgenic mice have severe eye abnormalities on some genetic backgrounds in the absence of LoxP sites (Q35291610)

7 August 2017

title

Hemizygous Le-Cre transgenic mice have severe eye abnormalities on some genetic backgrounds in the absence of LoxP sites (English)

1 reference

7 August 2017

1 reference

John D West

4

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author name string

Natalie J Dorà

series ordinal

1

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7 August 2017

J Martin Collinson

series ordinal

2

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7 August 2017

Robert E Hill

series ordinal

3

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7 August 2017

language of work or name

English

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publication date

1 October 2014

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7 August 2017

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7 August 2017

volume

9

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7 August 2017

issue

10

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7 August 2017

page(s)

e109193

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Creative Commons Attribution 4.0 International

7 August 2017

copyright license

start time

1 October 2014

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

Cre recombinase induces DNA damage and tetraploidy in the absence of loxP sites

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182886

Increased corneal epithelial turnover contributes to abnormal homeostasis in the Pax6( /-) mouse model of aniridia

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182886

Critical role of Klf5 in regulating gene expression during post-eyelid opening maturation of mouse corneas

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182886

Deletion of HIF-1α partially rescues the abnormal hyaloid vascular system in Cited2 conditional knockout mouse eyes

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182886

Integrin-linked kinase deletion in the developing lens leads to capsule rupture, impaired fiber migration and non-apoptotic epithelial cell death.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182886

Evidence for baseline retinal pigment epithelium pathology in the Trp1-Cre mouse

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182886

Effects of aberrant Pax6 gene dosage on mouse corneal pathophysiology and corneal epithelial homeostasis

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182886

Rac1 GTPase-deficient mouse lens exhibits defects in shape, suture formation, fiber cell migration and survival

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182886

Spry1andSpry2Are Necessary for Lens Vesicle Separation and Corneal Differentiation

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182886

Genetic epistasis between heparan sulfate and FGF–Ras signaling controls lens development

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182886

Good planning and serendipity: exploiting the Cre/Lox system in the testis

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182886

Regulation of Corneal Epithelial Barrier Function by Krüppel-like Transcription Factor 4

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182886

Disruption of mouse corneal epithelial differentiation by conditional inactivation of pnn.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182886

Conditional deletion of Cited2 results in defective corneal epithelial morphogenesis and maintenance.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182886

Normal ventral telencephalic expression of Pax6 is required for normal development of thalamocortical axons in embryonic mice.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182886

Effects of elevated Pax6 expression and genetic background on mouse eye development

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182886

The function of VEGF-A in lens development: formation of the hyaloid capillary network and protection against transient nuclear cataracts.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182886

Cited2 is required for the proper formation of the hyaloid vasculature and for lens morphogenesis

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182886

PAX6 dosage effects on corneal development, growth, and wound healing

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182886

Promiscuous recombination of LoxP alleles during gametogenesis in cornea Cre driver mice.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182886

Cre activity causes widespread apoptosis and lethal anemia during embryonic development.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182886

Vagaries of conditional gene targeting

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182886

Cryptic loxP sites in mammalian genomes: genome-wide distribution and relevance for the efficiency of BAC/PAC recombineering techniques.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182886

Six3 activation of Pax6 expression is essential for mammalian lens induction and specification

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182886

Cytokeratin 15 can be used to identify the limbal phenotype in normal and diseased ocular surfaces

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182886

Conditional deletion of the mouse Klf4 gene results in corneal epithelial fragility, stromal edema, and loss of conjunctival goblet cells

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182886

High levels of Cre expression in neuronal progenitors cause defects in brain development leading to microencephaly and hydrocephaly.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182886

The roles of calcium signaling and ERK1/2 phosphorylation in a Pax6 /- mouse model of epithelial wound-healing delay

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182886

Abnormal migration and distribution of neural crest cells in Pax6 heterozygous mutant eye, a model for human eye diseases.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182886

RIP-Cre revisited, evidence for impairments of pancreatic beta-cell function

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182886

Targeted deletion of AP-2alpha leads to disruption in corneal epithelial cell integrity and defects in the corneal stroma

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182886

The duality of beta-catenin function: a requirement in lens morphogenesis and signaling suppression of lens fate in periocular ectoderm

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182886

Developmental and cellular factors underlying corneal epithelial dysgenesis in the Pax6 /- mouse model of aniridia

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182886

Practical range of effective dose for Cre recombinase-expressing recombinant adenovirus without cell toxicity in mammalian cells

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182886

Delivery of the Cre recombinase by a self-deleting lentiviral vector: efficient gene targeting in vivo

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182886

Self-excising retroviral vectors encoding the Cre recombinase overcome Cre-mediated cellular toxicity

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182886

Growth inhibition and DNA damage induced by Cre recombinase in mammalian cells

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182886

Primary defects in the lens underlie complex anterior segment abnormalities of the Pax6 heterozygous eye.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182886

Illegitimate Cre-dependent chromosome rearrangements in transgenic mouse spermatids

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182886

Pax6 activity in the lens primordium is required for lens formation and for correct placement of a single retina in the eye

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182886

Targeting of cre to the Foxg1 (BF-1) locus mediates loxP recombination in the telencephalon and other developing head structures

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182886

Mammalian genomes contain active recombinase recognition sites

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182886

Corneal epithelium-specific mouse keratin K12 promoter.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182886

Genetic background effects on dental and other craniofacial abnormalities in homozygous small eye ( Pax6 Sey /Pax6 Sey ) mice

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182886

Conjunctival epithelial cells can resurface denuded cornea, but do not transdifferentiate to express cornea-specific keratin 12 following removal of limbal epithelium in mouse

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182886

Influence of PAX6 gene dosage on development: overexpression causes severe eye abnormalities

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182886

Multiple functions for Pax6 in mouse eye and nasal development.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182886

Cornea-specific expression of K12 keratin during mouse development.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4182886

Signaling through FGF receptor-2 is required for lens cell survival and for withdrawal from the cell cycle during lens fiber cell differentiation.

12 July 2018

1 reference

https://api.crossref.org/works/10.1371/JOURNAL.PONE.0109193

Conditional disruption of mouse Klf5 results in defective eyelids with malformed meibomian glands, abnormal cornea and loss of conjunctival goblet cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1371/JOURNAL.PONE.0109193

Corneal Abnormalities inPax6 /−Small Eye Mice Mimic Human Aniridia-Related Keratopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1371/JOURNAL.PONE.0109193

Requirement for Pax6 in corneal morphogenesis: a role in adhesion

21 January 2018

1 reference

https://api.crossref.org/works/10.1371/JOURNAL.PONE.0109193

Corneal development, limbal stem cell function, and corneal epithelial cell migration in the Pax6( /-) mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1371/JOURNAL.PONE.0109193

Reduced expression of Pax6 in lens and cornea of mutant mice leads to failure of chamber angle development and juvenile glaucoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371/JOURNAL.PONE.0109193

Z/AP, a double reporter for cre-mediated recombination.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371/JOURNAL.PONE.0109193

Histopathological characterisation of effects of the mouse Pax6(Leca4) missense mutation on eye development

21 January 2018

1 reference

https://api.crossref.org/works/10.1371/JOURNAL.PONE.0109193

Metabolic pitfalls of CNS Cre-based technology

21 January 2018

1 reference

https://api.crossref.org/works/10.1371/JOURNAL.PONE.0109193

Synapsin I Cre transgene expression in male mice produces germline recombination in progeny

21 January 2018

1 reference

https://api.crossref.org/works/10.1371/JOURNAL.PONE.0109193

Dilated cardiomyopathy resulting from high-level myocardial expression of Cre-recombinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371/JOURNAL.PONE.0109193

Direct hematological toxicity and illegitimate chromosomal recombination caused by the systemic activation of CreERT2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371/JOURNAL.PONE.0109193

Paracrine Pax6 activity regulates oligodendrocyte precursor cell migration in the chick embryonic neural tube

21 January 2018

1 reference

12 December 2020

The lens organizes the anterior segment: specification of neural crest cell differentiation in the avian eye

1 reference

12 December 2020

Dosage requirement and allelic expression of PAX6 during lens placode formation

1 reference

12 December 2020

Ultrastructural, immunohistological and biochemical characterization of cultured mouse corneal epithelial cells

1 reference

12 December 2020

Identification of the cornea-specific keratin 12 promoter by in vivo particle-mediated gene transfer

1 reference

12 December 2020

Increased Apoptosis and Abnormal Wound-Healing Responses in the HeterozygousPax6 /−Mouse Cornea

1 reference

12 December 2020

Genetic dissection of Pax6 dosage requirements in the developing mouse eye

1 reference

12 December 2020

10.1371/JOURNAL.PONE.0109193

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DOI

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7 August 2017

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7 August 2017

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