Molecular determinants for activation of human ether-à-go-go-related gene 1 potassium channels by 3-nitro-n-(4-phenoxyphenyl) benzamide. (Q35275326)

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7 February 2020

title

Molecular determinants for activation of human ether-à-go-go-related gene 1 potassium channels by 3-nitro-n-(4-phenoxyphenyl) benzamide (English)

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7 February 2020

3

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7 February 2020

author name string

Vivek Garg

series ordinal

1

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7 February 2020

Anna Stary-Weinzinger

series ordinal

2

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7 February 2020

Michael C Sanguinetti

series ordinal

4

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7 February 2020

publication date

8 July 2011

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7 February 2020

published in

Molecular Pharmacology

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7 February 2020

volume

80

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7 February 2020

issue

4

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7 February 2020

page(s)

630-637

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GROMACS 4: Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation

7 February 2020

cites work

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Structural basis for the coupling between activation and inactivation gates in K( ) channels

12 July 2018

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Structural mechanism of C-type inactivation in K( ) channels

12 July 2018

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PD-118057 contacts the pore helix of hERG1 channels to attenuate inactivation and enhance K conductance

12 July 2018

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Structural basis of action for a human ether-a-go-go-related gene 1 potassium channel activator.

12 July 2018

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Characterizing the 1,4-dihydropyridines binding interactions in the L-type Ca2 channel: model construction and docking calculations

12 July 2018

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12 July 2018

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hERG potassium channels and cardiac arrhythmia

12 July 2018

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Activation of human ether-a-go-go-related gene potassium channels by the diphenylurea 1,3-bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643).

12 July 2018

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Predicting drug-hERG channel interactions that cause acquired long QT syndrome.

12 July 2018

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Discovery of a small molecule activator of the human ether-a-go-go-related gene (HERG) cardiac K channel

12 July 2018

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Sudden death associated with short-QT syndrome linked to mutations in HERG.

12 July 2018

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Troubleshooting problems with in vitro screening of drugs for QT interval prolongation using HERG K channels expressed in mammalian cell lines and Xenopus oocytes

12 July 2018

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Gating currents associated with intramembrane charge displacement in HERG potassium channels

12 July 2018

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A structural basis for drug-induced long QT syndrome

12 July 2018

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12 July 2018

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Cut-open oocyte voltage-clamp technique

12 July 2018

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Molecular Determinants of Dofetilide Block of HERG K Channels

12 July 2018

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Molecular determinants of drug binding and action on L-type calcium channels

12 July 2018

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Molecular dynamics simulations of a fluid bilayer of dipalmitoylphosphatidylcholine at full hydration, constant pressure, and constant temperature

12 July 2018

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Single HERG delayed rectifier K channels expressed in Xenopus oocytes

12 July 2018

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The IVS6 segment of the L-type calcium channel is critical for the action of dihydropyridines and phenylalkylamines.

12 July 2018

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The inward rectification mechanism of the HERG cardiac potassium channel

12 July 2018

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A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome

12 July 2018

1 reference

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A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel

12 July 2018

1 reference

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HERG, a Human Inward Rectifier in the Voltage-Gated Potassium Channel Family

12 July 2018

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Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

12 July 2018

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Chapter 25 Expression of Ion Channels by Injection of mRNA into Xenopus Oocytes

12 July 2018

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Electrophysiological recording from Xenopus oocytes

12 July 2018

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Toward a consensus model of the HERG potassium channel

12 July 2018

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Pharmacological removal of human ether-à-go-go-related gene potassium channel inactivation by 3-nitro-N-(4-phenoxyphenyl) benzamide (ICA-105574).

26 September 2018

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Side chain flexibilities in the human ether-a-go-go related gene potassium channel (hERG) together with matched-pair binding studies suggest a new binding mode for channel blockers.

26 September 2018

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Structural model for dihydropyridine binding to L-type calcium channels

26 September 2018

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26 September 2018

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Mechanism of action of a novel human ether-a-go-go-related gene channel activator

26 September 2018

1 reference

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Novel potent human ether-a-go-go-related gene (hERG) potassium channel enhancers and their in vitro antiarrhythmic activity

26 September 2018

1 reference

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Physicochemical features of the HERG channel drug binding site

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3187531

Molecular determinants for activation and inactivation of HERG, a human inward rectifier potassium channel

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3187531

Molecular recognition of receptor sites using a genetic algorithm with a description of desolvation

26 September 2018

1 reference

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Voltage clamping of Xenopus laevis oocytes utilizing agarose-cushion electrodes.

26 September 2018

1 reference

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26 September 2018

Identifiers

DOI

10.1124/MOL.111.073809

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21743002 AND SRC:MED&resulttype=core&format=json

7 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21743002 AND SRC:MED&resulttype=core&format=json

7 February 2020

PubMed publication ID

21743002

1 reference