Genetically engineered SCN5A mutant pig hearts exhibit conduction defects and arrhythmias. (Q35242478)

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24 February 2020

title

Genetically engineered SCN5A mutant pig hearts exhibit conduction defects and arrhythmias (English)

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24 February 2020

2

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24 February 2020

Steven J Fowler

5

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24 February 2020

author name string

David S Park

1

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24 February 2020

Gregory Morley

3

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24 February 2020

Carolina Vasquez

4

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24 February 2020

Nian Liu

6

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24 February 2020

Scott A Bernstein

7

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24 February 2020

Fang-Yu Liu

8

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24 February 2020

Jie Zhang

9

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24 February 2020

Christopher S Rogers

10

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24 February 2020

Silvia G Priori

11

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24 February 2020

Larry A Chinitz

12

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24 February 2020

Glenn I Fishman

13

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24 February 2020

language of work or name

English

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publication date

15 December 2014

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Journal of Clinical Investigation

24 February 2020

published in

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24 February 2020

volume

125

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24 February 2020

issue

1

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24 February 2020

page(s)

403-412

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Desmosomes and the sodium channel complex: implications for arrhythmogenic cardiomyopathy and Brugada syndrome

24 February 2020

cites work

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Sodium current reduction unmasks a structure-dependent substrate for arrhythmogenesis in the normal ventricles

12 July 2018

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Prevalence and prognostic role of various conduction disturbances in patients with the Brugada syndrome

12 July 2018

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Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death

12 July 2018

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A heterozygous deletion mutation in the cardiac sodium channel gene SCN5A with loss- and gain-of-function characteristics manifests as isolated conduction disease, without signs of Brugada or long QT syndrome

12 July 2018

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12 July 2018

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Dominant-negative effect of SCN5A N-terminal mutations through the interaction of Na(v)1.5 α-subunits

12 July 2018

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Dynamic reciprocity of sodium and potassium channel expression in a macromolecular complex controls cardiac excitability and arrhythmia

12 July 2018

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Reduced heterogeneous expression of Cx43 results in decreased Nav1.5 expression and reduced sodium current that accounts for arrhythmia vulnerability in conditional Cx43 knockout mice

12 July 2018

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Electrocardiographic Characteristics and SCN5A Mutations in Idiopathic Ventricular Fibrillation Associated With Early Repolarization

12 July 2018

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HRS/EHRA expert consensus statement on the state of genetic testing for the channelopathies and cardiomyopathies: this document was developed as a partnership between the Heart Rhythm Society (HRS) and the European Heart Rhythm Association (EHRA).

12 July 2018

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Targeting atrioventricular differences in ion channel properties for terminating acute atrial fibrillation in pigs

12 July 2018

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The pathophysiological mechanism underlying Brugada syndrome: depolarization versus repolarization

12 July 2018

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Loss of plakophilin-2 expression leads to decreased sodium current and slower conduction velocity in cultured cardiac myocytes

12 July 2018

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Evaluation of cardiovascular and ECG parameters in the normal, freely moving Göttingen Minipig

12 July 2018

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Production of CFTR-null and CFTR-DeltaF508 heterozygous pigs by adeno-associated virus-mediated gene targeting and somatic cell nuclear transfer

12 July 2018

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Cardiac histological substrate in patients with clinical phenotype of Brugada syndrome

12 July 2018

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Malignant entity of idiopathic ventricular fibrillation and polymorphic ventricular tachycardia initiated by premature extrasystoles originating from the right ventricular outflow tract

12 July 2018

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Brugada syndrome and fever: genetic and molecular characterization of patients carrying SCN5A mutations.

12 July 2018

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12 July 2018

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ANATOMIC BASIS FOR ATRIOVENTRICULAR BLOCK.

12 July 2018

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A newly characterized SCN5A mutation underlying Brugada syndrome unmasked by hyperthermia.

12 July 2018

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Novel SCN5A mutation leading either to isolated cardiac conduction defect or Brugada syndrome in a large French family

12 July 2018

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Sodium channel blockers identify risk for sudden death in patients with ST-segment elevation and right bundle branch block but structurally normal hearts

12 July 2018

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Ionic mechanisms responsible for the electrocardiographic phenotype of the Brugada syndrome are temperature dependent

12 July 2018

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12 July 2018

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Cardiac conduction defects associate with mutations in SCN5A

12 July 2018

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12 July 2018

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12 July 2018

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Circadian rhythm of heat production, heart rate, and skin and core temperature under unmasking conditions in men.

12 July 2018

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Isolation of single atrial and ventricular cells from the human heart

12 July 2018

1 reference

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SCN5A mutations associate with arrhythmic dilated cardiomyopathy and commonly localize to the voltage-sensing mechanism.

12 July 2018

1 reference

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Identification of low and high frequency ranges for heart rate variability and blood pressure variability analyses using pharmacological autonomic blockade with atropine and propranolol in swine

26 September 2018

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Facilitatory and inhibitory effects of SCN5A mutations on atrial fibrillation in Brugada syndrome

26 September 2018

1 reference

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Short coupled premature ventricular contraction initiating ventricular fibrillation in a patient with Brugada syndrome

26 September 2018

1 reference

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Calcium-activated transient outward chloride current and phase 1 repolarization of swine ventricular action potential

26 September 2018

1 reference

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A New Technique to Perform Epicardial Mapping in the Electrophysiology Laboratory

26 September 2018

1 reference

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Progressive cardiac conduction defect is the prevailing phenotype in carriers of a Brugada syndrome SCN5A mutation

15 November 2018

1 reference

12 December 2020

Fever increases the risk for cardiac arrest in the Brugada syndrome

1 reference

12 December 2020

Prevention of Ventricular Fibrillation Episodes in Brugada Syndrome by Catheter Ablation Over the Anterior Right Ventricular Outflow Tract Epicardium

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12 December 2020

Connexin43 regulates sodium current; ankyrin-G modulates gap junctions: the intercalated disc exchanger

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12 December 2020

Mode of onset of ventricular fibrillation in patients with Brugada syndrome detected by implantable cardioverter defibrillator therapy

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12 December 2020

Fever and Brugada syndrome

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12 December 2020

Haploinsufficiency in combination with aging causes SCN5A-linked hereditary Lenègre disease

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12 December 2020

Identifiers

DOI

10.1172/JCI76919

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25500882 AND SRC:MED&resulttype=core&format=json

24 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25500882 AND SRC:MED&resulttype=core&format=json

24 February 2020

PubMed publication ID

25500882

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25500882 AND SRC:MED&resulttype=core&format=json