Evidence of non-pancreatic beta cell-dependent roles of Tcf7l2 in the regulation of glucose metabolism in mice (Q35239299)

7 August 2017

title

Evidence of non-pancreatic beta cell-dependent roles of Tcf7l2 in the regulation of glucose metabolism in mice (English)

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7 August 2017

9

Graeme I Bell

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7 August 2017

Kathleen A Bailey

1

1 reference

7 August 2017

Daniel Savic

2

1 reference

7 August 2017

Mark Zielinski

3

1 reference

7 August 2017

Soo-Young Park

4

1 reference

7 August 2017

Ling-Jia Wang

5

1 reference

7 August 2017

Piotr Witkowski

6

1 reference

7 August 2017

Matthew Brady

7

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7 August 2017

Manami Hara

8

1 reference

7 August 2017

Marcelo A Nobrega

10

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7 August 2017

publication date

14 November 2014

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7 August 2017

published in

Human Molecular Genetics

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7 August 2017

volume

24

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7 August 2017

issue

6

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7 August 2017

page(s)

1646-1654

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describes a project that uses

7 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4381752/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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TCF7L2 is a master regulator of insulin production and processing

12 July 2018

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Loss-of-function mutations in SLC30A8 protect against type 2 diabetes

12 July 2018

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12 July 2018

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TCF7L2 and glucose metabolism: time to look beyond the pancreas

12 July 2018

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Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic response to perinatal and adult metabolic demand

12 July 2018

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12 July 2018

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TCF7L2 rs7903146 impairs islet function and morphology in non-diabetic individuals

12 July 2018

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Reduction in Tcf7l2 expression decreases diabetic susceptibility in mice

12 July 2018

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12 July 2018

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An in vivo cis-regulatory screen at the type 2 diabetes associated TCF7L2 locus identifies multiple tissue-specific enhancers

12 July 2018

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Reduced insulin exocytosis in human pancreatic β-cells with gene variants linked to type 2 diabetes

12 July 2018

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Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci

12 July 2018

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Transcriptional enhancers in development and disease

12 July 2018

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Altered islet composition and disproportionate loss of large islets in patients with type 2 diabetes

12 July 2018

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Alterations in TCF7L2 expression define its role as a key regulator of glucose metabolism

12 July 2018

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Computer-assisted Large-scale Visualization and Quantification of Pancreatic Islet Mass, Size Distribution and Architecture

12 July 2018

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Global epigenomic analysis of primary human pancreatic islets provides insights into type 2 diabetes susceptibility loci

12 July 2018

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Genome‐wide maps of transcription regulatory elements

12 July 2018

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Conditional gene targeting in mouse pancreatic ß-Cells: analysis of ectopic Cre transgene expression in the brain.

12 July 2018

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Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

12 July 2018

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12 July 2018

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Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell function

12 July 2018

1 reference

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TCF7L2 regulates late events in insulin secretion from pancreatic islet beta-cells

12 July 2018

1 reference

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RETRACTED: Transcription factor 7-like 2 regulates beta-cell survival and function in human pancreatic islets

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4381752

Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes

12 July 2018

1 reference

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Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes

12 July 2018

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A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants

12 July 2018

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Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels

12 July 2018

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Wnt signaling regulates pancreatic beta cell proliferation

12 July 2018

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A genome-wide association study identifies novel risk loci for type 2 diabetes

12 July 2018

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Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes

12 July 2018

1 reference

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Abnormal glucose tolerance and insulin secretion in pancreas-specific Tcf7l2-null mice.

12 July 2018

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Encapsulation of pancreatic islets within nano-thin functional polyethylene glycol coatings for enhanced insulin secretion

26 September 2018

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TCF7L2 controls insulin gene expression and insulin secretion in mature pancreatic beta-cells

26 September 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4381752

Optical imaging of pancreatic beta cells in living mice expressing a mouse insulin I promoter-firefly luciferase transgene

26 September 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4381752

Transcription Factor TCF7L2 Genetic Study in the French Population: Expression in Human -Cells and Adipose Tissue and Strong Association With Type 2 Diabetes

26 September 2018

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Crossref

https://api.crossref.org/works/10.1093/HMG/DDU577

Automated, high-throughput assays for evaluation of human pancreatic islet function

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1093/HMG/DDU577

Coating human pancreatic islets with CD4( )CD25(high)CD127(-) regulatory T cells as a novel approach for the local immunoprotection

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25398947

12 December 2020

inferred from PubMed ID database lookup

TCF7L2 promotes beta cell regeneration in human and mouse pancreas

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25398947

12 December 2020

inferred from PubMed ID database lookup

Zinc transport and diabetes risk

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25398947

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1093/HMG/DDU577

1 reference

release_to6m5ejzlba27ks7poff5lji5i

7 August 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/to6m5ejzlba27ks7poff5lji5i

24 November 2022

mapped directly with Wikidata item

PMC publication ID

4381752

1 reference

7 August 2017

1 reference