Notch signaling inhibits hepatocellular carcinoma following inactivation of the RB pathway. (Q35237526)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21875955 AND SRC:MED&resulttype=core&format=json

11 February 2020

title

Notch signaling inhibits hepatocellular carcinoma following inactivation of the RB pathway (English)

1 reference

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11 February 2020

main subject

hepatocellular carcinoma

1 reference

5

1 reference

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11 February 2020

Pawel K Mazur

8

1 reference

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11 February 2020

Otto Hannes Vogel

11

1 reference

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11 February 2020

Markus Grompe

14

1 reference

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11 February 2020

15

Julien Sage

1 reference

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11 February 2020

author name string

Patrick Viatour

1

1 reference

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11 February 2020

Ursula Ehmer

2

1 reference

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11 February 2020

Louis A Saddic

3

1 reference

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11 February 2020

Craig Dorrell

4

1 reference

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11 February 2020

Chenwei Lin

6

1 reference

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11 February 2020

Anne-Flore Zmoos

7

1 reference

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11 February 2020

Bethany E Schaffer

9

1 reference

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11 February 2020

Austin Ostermeier

10

1 reference

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11 February 2020

Karl G Sylvester

12

1 reference

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11 February 2020

Snorri S Thorgeirsson

13

1 reference

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11 February 2020

language of work or name

English

0 references

publication date

29 August 2011

1 reference

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Journal of Experimental Medicine

11 February 2020

published in

1 reference

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11 February 2020

volume

208

1 reference

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11 February 2020

issue

10

1 reference

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11 February 2020

page(s)

1963-1976

1 reference

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Foxl1-Cre-marked adult hepatic progenitors have clonogenic and bilineage differentiation potential

11 February 2020

cites work

1 reference

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Fbxw7 regulates lipid metabolism and cell fate decisions in the mouse liver

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Jagged1 in the portal vein mesenchyme regulates intrahepatic bile duct development: insights into Alagille syndrome

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Hepatic progenitor cells: an update

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The cyclin E regulator cullin 3 prevents mouse hepatic progenitor cells from becoming tumor-initiating cells

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Mitogen-activated protein kinases in hepatocellular carcinoma development

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Local Mesenchymal Stem/Progenitor Cells Are a Preferential Target for Initiation of Adult Soft Tissue Sarcomas Associated with p53 and Rb Deficiency

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Rb regulates fate choice and lineage commitment in vivo

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Rb deletion in mouse mammary progenitors induces luminal-B or basal-like/EMT tumor subtypes depending on p53 status

27 July 2018

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Nf2/Merlin controls progenitor homeostasis and tumorigenesis in the liver

27 July 2018

1 reference

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The role of signaling pathways in the development and treatment of hepatocellular carcinoma

27 July 2018

1 reference

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Notch2 is required for progression of pancreatic intraepithelial neoplasia and development of pancreatic ductal adenocarcinoma

27 July 2018

1 reference

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Loss of Rb proteins causes genomic instability in the absence of mitogenic signaling

27 July 2018

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The changing pattern of epidemiology in hepatocellular carcinoma

27 July 2018

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Notch1 functions as a tumor suppressor in a model of K-ras-induced pancreatic ductal adenocarcinoma

27 July 2018

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Combined functional genome survey of therapeutic targets for hepatocellular carcinoma

27 July 2018

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Dissecting the unique role of the retinoblastoma tumor suppressor during cellular senescence

27 July 2018

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Regulation of RB transcription in vivo by RB family members

27 July 2018

1 reference

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RB has a critical role in mediating the in vivo checkpoint response, mitigating secondary DNA damage and suppressing liver tumorigenesis initiated by aflatoxin B1

27 July 2018

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A lymphotoxin-driven pathway to hepatocellular carcinoma

27 July 2018

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27 July 2018

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The retinoblastoma gene Rb and its family member p130 suppress lung adenocarcinoma induced by oncogenic K-Ras.

27 July 2018

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The epidemiology of hepatocellular cancer: from the perspectives of public health problem to tumor biology

27 July 2018

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Tailoring to RB: tumour suppressor status and therapeutic response

27 July 2018

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Liver stem cells and hepatocellular carcinoma

27 July 2018

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Hematopoietic stem cell quiescence is maintained by compound contributions of the retinoblastoma gene family

27 July 2018

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27 July 2018

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27 July 2018

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Cellular mechanisms of tumour suppression by the retinoblastoma gene.

27 July 2018

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Hepatitis B virus X protein via the p38MAPK pathway induces E2F1 release and ATR kinase activation mediating p53 apoptosis

27 July 2018

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27 July 2018

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27 July 2018

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Hepatitis C Virus Induces E6AP-Dependent Degradation of the Retinoblastoma Protein

27 July 2018

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The Retinoblastoma family member p107 regulates the rate of progenitor commitment to a neuronal fate.

27 July 2018

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27 July 2018

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27 July 2018

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27 July 2018

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Hepatic progenitor cells in human liver tumor development

27 July 2018

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Nucleocytoplasmic shuttling of the retinoblastoma tumor suppressor protein via Cdk phosphorylation-dependent nuclear export

27 July 2018

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27 July 2018

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27 July 2018

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27 July 2018

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Notch signaling is a potent inducer of growth arrest and apoptosis in a wide range of B-cell malignancies

27 July 2018

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Frequent trefoil factor 3 (TFF3) overexpression and promoter hypomethylation in mouse and human hepatocellular carcinomas

27 July 2018

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p107 regulates neural precursor cells in the mammalian brain

27 July 2018

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Direct regulation of the Nrarp gene promoter by the Notch signaling pathway

27 July 2018

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Stem cells and cancer; the polycomb connection

27 July 2018

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Progenitor cells in diseased human liver

27 July 2018

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Notch1 signaling inhibits growth of human hepatocellular carcinoma through induction of cell cycle arrest and apoptosis.

27 July 2018

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Notch1 functions as a tumor suppressor in mouse skin

27 July 2018

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Hepatic progenitors and strategies for liver cell therapies

27 July 2018

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Significance analysis of microarrays applied to the ionizing radiation response

27 July 2018

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Reduced stability of retinoblastoma protein by gankyrin, an oncogenic ankyrin-repeat protein overexpressed in hepatomas

27 July 2018

1 reference

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Cluster analysis and display of genome-wide expression patterns

27 July 2018

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Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1

27 July 2018

1 reference

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Common antigen of oval and biliary epithelial cells (A6) is a differentiation marker of epithelial and erythroid cell lineages in early development of the mouse

27 July 2018

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Extensive contribution of Rb-deficient cells to adult chimeric mice with limited histopathological consequences

27 July 2018

1 reference

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Prospective isolation of a bipotential clonogenic liver progenitor cell in adult mice.

27 July 2018

1 reference

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Identification of epidermal Pdx1 expression discloses different roles of Notch1 and Notch2 in murine Kras(G12D)-induced skin carcinogenesis in vivo

26 September 2018

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Hepatitis B virus X protein overcomes stress-induced premature senescence by repressing p16(INK4a) expression via DNA methylation

26 September 2018

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Stem cells and liver regeneration.

26 September 2018

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Signaling networks in hepatic oval cell activation.

26 September 2018

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Notch signaling controls liver development by regulating biliary differentiation

26 September 2018

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The isolation and in vitro expansion of hepatic Sca-1 progenitor cells

26 September 2018

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Liver-specific inactivation of Notch2, but not Notch1, compromises intrahepatic bile duct development in mice.

26 September 2018

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Identification of adult hepatic progenitor cells capable of repopulating injured rat liver

26 September 2018

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Hepatitis B virus pre-S2 mutant surface antigen induces degradation of cyclin-dependent kinase inhibitor p27Kip1 through c-Jun activation domain-binding protein 1.

26 September 2018

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Genomics and signaling pathways in hepatocellular carcinoma.

26 September 2018

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Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis

26 September 2018

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Transcriptome classification of HCC is related to gene alterations and to new therapeutic targets

26 September 2018

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Up-regulation of cyclin D1 by HBx is mediated by NF-kappaB2/BCL3 complex through kappaB site of cyclin D1 promoter.

26 September 2018

1 reference

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Hepatocellular carcinoma pathogenesis: from genes to environment

26 September 2018

1 reference

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The phenotypes of pluripotent human hepatic progenitors.

26 September 2018

1 reference

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Inducible inactivation of Notch1 causes nodular regenerative hyperplasia in mice.

26 September 2018

1 reference

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Application of comparative functional genomics to identify best-fit mouse models to study human cancer

26 September 2018

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Alterations of RB1, p53 and Wnt pathways in hepatocellular carcinomas associated with hepatitis C, hepatitis B and alcoholic liver cirrhosis

26 September 2018

1 reference

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In situ detection of insulin-like growth factor II (IGF2) and H19 gene expression in hepatocellular carcinoma.

26 September 2018

1 reference

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Liver-specific pRB loss results in ectopic cell cycle entry and aberrant ploidy

26 September 2018

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12 December 2020

Aflatoxin B1 and polycyclic aromatic hydrocarbon adducts, p53 mutations and p16 methylation in liver tissue and plasma of hepatocellular carcinoma patients

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12 December 2020

Dual functions of E2F-1 in a transgenic mouse model of liver carcinogenesis

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12 December 2020

The stem cell niche of human livers: symmetry between development and regeneration

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12 December 2020

Identifiers

DOI

10.1084/JEM.20110198

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21875955 AND SRC:MED&resulttype=core&format=json

11 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21875955 AND SRC:MED&resulttype=core&format=json

11 February 2020

PubMed publication ID

21875955

1 reference