Multi-species Analyses of Direct Activators of the Constitutive Androstane Receptor (Q35231096)

7 August 2017

title

Multi-species analyses of direct activators of the constitutive androstane receptor (English)

1 reference

7 August 2017

Multi-species Analyses of Direct Activators of the Constitutive Androstane Receptor (English)

1 reference

Crossref

DOI

10.1093/TOXSCI/KFR191

https://api.crossref.org/works/10.1093/TOXSCI/KFR191

7 December 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:21778469

7 December 2024

author name string

Tao Chen

3

1 reference

7 August 2017

Curtis J. Omiecinski

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:21778469

7 December 2024

Denise M. Coslo

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:21778469

7 December 2024

Elizabeth M. Laurenzana

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:21778469

7 December 2024

Richard C. Peffer

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:21778469

7 December 2024

language of work or name

1 reference

21 July 2011

1 reference

full work available at URL

7 August 2017

https://academic.oup.com/toxsci/article-pdf/123/2/550/16683210/kfr191.pdf

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:21778469

https://europepmc.org/articles/PMC3179682

7 December 2024

file format

HyperText Markup Language

online access status

open access

content deliverer

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:21778469

https://europepmc.org/articles/PMC3179682?pdf=render

7 December 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:21778469

https://doi.org/10.1093/toxsci/kfr191

7 December 2024

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:21778469

http://academic.oup.com/toxsci/article-pdf/123/2/550/16683210/kfr191.pdf

7 December 2024

1 reference

10.1093/TOXSCI/KFR191

https://api.crossref.org/works/10.1093/TOXSCI/KFR191

7 December 2024

published in

Toxicological Sciences

1 reference

7 August 2017

volume

123

1 reference

7 August 2017

issue

2

1 reference

7 August 2017

page(s)

550-562

1 reference

Selective Phthalate Activation of Naturally Occurring Human Constitutive Androstane Receptor Splice Variants and the Pregnane X Receptor

7 August 2017

cites work

1 reference

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Coupling of receptor conformation and ligand orientation determine graded activity

13 July 2018

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Pregnane X Receptor and Constitutive Androstane Receptor at the Crossroads of Drug Metabolism and Energy Metabolism

13 July 2018

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Dephosphorylation of threonine 38 is required for nuclear translocation and activation of human xenobiotic receptor CAR (NR1I3).

13 July 2018

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A single amino acid controls the functional switch of human constitutive androstane receptor (CAR) 1 to the xenobiotic-sensitive splicing variant CAR3.

13 July 2018

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Di(2-ethylhexyl) phthalate is a highly potent agonist for the human constitutive androstane receptor splice variant CAR2.

13 July 2018

1 reference

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The nuclear receptor CAR (NR1I3) regulates serum triglyceride levels under conditions of metabolic stress

13 July 2018

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A novel panel of mouse models to evaluate the role of human pregnane X receptor and constitutive androstane receptor in drug response.

13 July 2018

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The tangle of nuclear receptors that controls xenobiotic metabolism and transport: crosstalk and consequences.

13 July 2018

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Gene expression profiling of extracellular matrix as an effector of human hepatocyte phenotype in primary cell culture

13 July 2018

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CAR2 displays unique ligand binding and RXRalpha heterodimerization characteristics

13 July 2018

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Relative activation of human pregnane X receptor versus constitutive androstane receptor defines distinct classes of CYP2B6 and CYP3A4 inducers

13 July 2018

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Evolution and function of the NR1I nuclear hormone receptor subfamily (VDR, PXR, and CAR) with respect to metabolism of xenobiotics and endogenous compounds

13 July 2018

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Synthetic drugs and natural products as modulators of constitutive androstane receptor (CAR) and pregnane X receptor (PXR).

13 July 2018

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Genetic variants of PXR (NR1I2) and CAR (NR1I3) and their implications in drug metabolism and pharmacogenetics

13 July 2018

1 reference

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Retinoid X receptor-alpha-dependent transactivation by a naturally occurring structural variant of human constitutive androstane receptor (NR1I3).

13 July 2018

1 reference

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Identification of HMG-CoA reductase inhibitors as activators for human, mouse and rat constitutive androstane receptor.

13 July 2018

1 reference

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Antimalarial artemisinin drugs induce cytochrome P450 and MDR1 expression by activation of xenosensors pregnane X receptor and constitutive androstane receptor.

13 July 2018

1 reference

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Hepatotoxicity of antifungal agents

13 July 2018

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Structure of the murine constitutive androstane receptor complexed to androstenol: a molecular basis for inverse agonism

13 July 2018

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Meclizine is an agonist ligand for mouse constitutive androstane receptor (CAR) and an inverse agonist for human CAR.

13 July 2018

1 reference

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Alternative splicing affects the function and tissue-specific expression of the human constitutive androstane receptor

13 July 2018

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A traditional herbal medicine enhances bilirubin clearance by activating the nuclear receptor CAR.

13 July 2018

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Alternatively spliced isoforms of the human constitutive androstane receptor

13 July 2018

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Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes

13 July 2018

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Functional and structural comparison of PXR and CAR.

13 July 2018

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A structural model of the constitutive androstane receptor defines novel interactions that mediate ligand-independent activity

13 July 2018

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Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

13 July 2018

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13 July 2018

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13 July 2018

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Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands

13 July 2018

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Androstane metabolites bind to and deactivate the nuclear receptor CAR-beta

13 July 2018

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13 July 2018

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13 July 2018

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An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs

13 July 2018

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Itraconazole-induced cholestasis: involvement of the inhibition of bile canalicular phospholipid translocator MDR3/ABCB4.

13 July 2018

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Human constitutive androstane receptor (CAR) and pregnane X receptor (PXR) support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogens phenobarbital and chlordane in vivo.

26 September 2018

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The xenobiotic-sensing nuclear receptors pregnane X receptor, constitutive androstane receptor, and orphan nuclear receptor hepatocyte nuclear factor 4alpha in the regulation of human steroid-/bile acid-sulfotransferase

26 September 2018

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Mode of action in relevance of rodent liver tumors to human cancer risk.

26 September 2018

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Xenobiotic stress induces hepatomegaly and liver tumors via the nuclear receptor constitutive androstane receptor

26 September 2018

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Q-SiteFinder: an energy-based method for the prediction of protein-ligand binding sites

26 September 2018

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A structural basis for constitutive activity in the human CAR/RXRalpha heterodimer

26 September 2018

1 reference

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The nuclear xenobiotic receptor CAR: structural determinants of constitutive activation and heterodimerization

26 September 2018

1 reference

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The orphan nuclear receptor constitutive active/androstane receptor is essential for liver tumor promotion by phenobarbital in mice

26 September 2018

1 reference

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The nuclear receptor CAR is a regulator of thyroid hormone metabolism during caloric restriction

26 September 2018

1 reference

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Identification of novel alternative splice variants of human constitutive androstane receptor and characterization of their expression in the liver

26 September 2018

1 reference

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Phenobarbital responsiveness as a uniquely sensitive indicator of hepatocyte differentiation status: requirement of dexamethasone and extracellular matrix in establishing the functional integrity of cultured primary rat hepatocytes

26 September 2018

1 reference

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Characterization of DNA complexes formed by the nuclear receptor constitutive androstane receptor

26 September 2018

1 reference

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A novel distal enhancer module regulated by pregnane X receptor/constitutive androstane receptor is essential for the maximal induction of CYP2B6 gene expression

26 September 2018

1 reference

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Cancer incidence among patients using antiepileptic drugs: a long-term follow-up of 28,000 patients

26 September 2018

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26 September 2018

Identifiers

DOI

10.1093/TOXSCI/KFR191

1 reference

7 August 2017

1 reference

7 August 2017

1 reference