Pharmacological profile of opicapone, a third-generation nitrocatechol catechol-O-methyl transferase inhibitor, in the rat. (Q35223930)

7 August 2017

title

Pharmacological profile of opicapone, a third-generation nitrocatechol catechol-O-methyl transferase inhibitor, in the rat. (English)

1 reference

7 August 2017

M J Bonifácio

1

1 reference

7 August 2017

L Torrão

2

1 reference

7 August 2017

A I Loureiro

3

1 reference

7 August 2017

P N Palma

4

1 reference

7 August 2017

L C Wright

5

1 reference

7 August 2017

P Soares-da-Silva

6

1 reference

7 August 2017

language of work or name

English

0 references

publication date

20 January 2015

1 reference

British Journal of Pharmacology

7 August 2017

published in

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7 August 2017

volume

172

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7 August 2017

issue

7

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7 August 2017

page(s)

1739-1752

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The Concise Guide to PHARMACOLOGY 2013/14: enzymes.

7 August 2017

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Opicapone: a short lived and very long acting novel catechol-O-methyltransferase inhibitor following multiple dose administration in healthy subjects

13 July 2018

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Determination of differential activities of soluble and membrane-bound catechol-O-methyltransferase in tissues and erythrocytes

13 July 2018

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13 July 2018

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Inhibition of catechol-O-methyltransferase activity by two novel disubstituted catechols in the rat.

13 July 2018

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Catechol-O-methyl transferase: pharmacological aspects and physiological role

13 July 2018

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Pharmacokinetics, pharmacodynamics and tolerability of opicapone, a novel catechol-O-methyltransferase inhibitor, in healthy subjects: prediction of slow enzyme-inhibitor complex dissociation of a short-living and very long-acting inhibitor.

13 July 2018

1 reference

Kinetic inhibitory profile of BIA 3-202, a novel fast tight-binding, reversible and competitive catechol-O-methyltransferase inhibitor.

21 January 2018

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Brain and peripheral pharmacokinetics of levodopa in the cynomolgus monkey following administration of opicapone, a third generation nitrocatechol COMT inhibitor

21 January 2018

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Discovery of a long-acting, peripherally selective inhibitor of catechol-O-methyltransferase.

21 January 2018

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Pharmacokinetic behaviour of levodopa and 3-O-methyldopa after repeat administration of levodopa/carbidopa with and without entacapone in patients with Parkinson's disease

21 January 2018

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Inhibition of catechol-O-methyltransferase contributes to more stable levodopa plasma levels

21 January 2018

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Computation of the binding affinities of catechol-O-methyltransferase inhibitors: multisubstate relative free energy calculations.

21 January 2018

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Distribution of catechol-O-methyltransferase enzyme in rat tissues

21 January 2018

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12 December 2020

Inhibition of soluble catechol-O-methyltransferase and single-dose pharmacokinetics after oral and intravenous administration of entacapone

1 reference

12 December 2020

Effect of opicapone and entacapone upon levodopa pharmacokinetics during three daily levodopa administrations

1 reference

12 December 2020

Fewer fluctuations, higher maximum concentration and better motor response of levodopa with catechol-O-methyltransferase inhibition

1 reference

12 December 2020

Identifiers

DOI

10.1111/BPH.13020

1 reference

7 August 2017

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7 August 2017

1 reference