The terminal enzymes of cholesterol synthesis, DHCR24 and DHCR7, interact physically and functionally. (Q35217051)

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29 February 2020

title

The terminal enzymes of cholesterol synthesis, DHCR24 and DHCR7, interact physically and functionally (English)

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29 February 2020

2

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29 February 2020

Laura J Sharpe

series ordinal

3

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29 February 2020

author name string

Winnie Luu

series ordinal

1

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29 February 2020

Andrew J Brown

series ordinal

4

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29 February 2020

publication date

31 January 2015

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Journal of Lipid Research

29 February 2020

published in

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29 February 2020

volume

56

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issue

4

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29 February 2020

page(s)

888-897

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describes a project that uses

29 February 2020

ImageQuant

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4373745/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

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DHCR24 associates strongly with the endoplasmic reticulum beyond predicted membrane domains: implications for the activities of this multi-functional enzyme.

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Signaling regulates activity of DHCR24, the final enzyme in cholesterol synthesis

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Desmosterol and DHCR24: unexpected new directions for a terminal step in cholesterol synthesis.

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Involvement of Akt in ER-to-Golgi transport of SCAP/SREBP: a link between a key cell proliferative pathway and membrane synthesis

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Cholesterol addition to ER membranes alters conformation of SCAP, the SREBP escort protein that regulates cholesterol metabolism

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Mutations in the 3beta-hydroxysterol Delta24-reductase gene cause desmosterolosis, an autosomal recessive disorder of cholesterol biosynthesis

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26 September 2018

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26 September 2018

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26 September 2018

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26 September 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/25637936

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1194/JLR.M056986

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25637936 AND SRC:MED&resulttype=core&format=json

29 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25637936 AND SRC:MED&resulttype=core&format=json

29 February 2020

PubMed publication ID

25637936

1 reference