Metabolic basis for the differential susceptibility of Gram-positive pathogens to fatty acid synthesis inhibitors. (Q35216999)

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11 February 2020

title

Metabolic basis for the differential susceptibility of Gram-positive pathogens to fatty acid synthesis inhibitors (English)

1 reference

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11 February 2020

main subject

fatty acid

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gram-positive bacteria

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author

Matthew W Frank

2

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11 February 2020

author name string

Joshua B Parsons

1

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11 February 2020

Chitra Subramanian

3

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11 February 2020

Panatda Saenkham

4

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11 February 2020

Charles O Rock

5

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11 February 2020

language of work or name

English

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publication date

29 August 2011

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Proceedings of the National Academy of Sciences of the United States of America

11 February 2020

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21876172 AND SRC:MED&resulttype=core&format=json

11 February 2020

volume

108

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11 February 2020

issue

37

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11 February 2020

page(s)

15378-15383

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The kalimantacin/batumin biosynthesis operon encodes a self-resistance isoform of the FabI bacterial target

11 February 2020

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AFN-1252, a FabI inhibitor, demonstrates a Staphylococcus-specific spectrum of activity

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Acyl-Acyl carrier protein regulates transcription of fatty acid biosynthetic genes via the FabT repressor in Streptococcus pneumoniae

13 July 2018

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Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties

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13 July 2018

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Platensimycin is a selective FabF inhibitor with potent antibiotic properties

13 July 2018

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Indole Naphthyridinones as Inhibitors of Bacterial Enoyl-ACP Reductases FabI and FabK

13 July 2018

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Characterization of Streptococcus pneumoniae enoyl-(acyl-carrier protein) reductase (FabK).

13 July 2018

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Discovery of a novel and potent class of FabI-directed antibacterial agents

13 July 2018

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Discovery of aminopyridine-based inhibitors of bacterial enoyl-ACP reductase (FabI)

13 July 2018

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Inhibition of Escherichia coli acetyl coenzyme A carboxylase by acyl-acyl carrier protein

13 July 2018

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Inhibition of beta-ketoacyl-acyl carrier protein synthases by thiolactomycin and cerulenin. Structure and mechanism

13 July 2018

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Broad spectrum antimicrobial biocides target the FabI component of fatty acid synthesis

13 July 2018

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Triclosan targets lipid synthesis

13 July 2018

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Inhibition of beta-ketoacyl-acyl carrier protein synthase III (FabH) by acyl-acyl carrier protein in Escherichia coli.

13 July 2018

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Thiolactomycin resistance in Escherichia coli is associated with the multidrug resistance efflux pump encoded by emrAB

13 July 2018

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Crystal structure and function of the isoniazid target of Mycobacterium tuberculosis

13 July 2018

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Thiolactomycin, a new antibiotic. III. In vitro antibacterial activity.

13 July 2018

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Acetoacetyl-acyl carrier protein synthase, a potential regulator of fatty acid biosynthesis in bacteria

13 July 2018

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Cerulenin-inhibited cells of Staphylococcus aureus resume growth when supplemented with either a saturated or an unsaturated fatty acid

13 July 2018

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The antibiotic cerulenin, a novel tool for biochemistry as an inhibitor of fatty acid synthesis

13 July 2018

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Essentiality of FASII pathway for Staphylococcus aureus

13 July 2018

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Aquastatin A, a new inhibitor of enoyl-acyl carrier protein reductase from Sporothrix sp. FN611.

26 September 2018

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Macrolactin S, a new antibacterial agent with FabG-inhibitory activity from Bacillus sp. AT28.

26 September 2018

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A malonyl-CoA-dependent switch in the bacterial response to a dysfunction of lipid metabolism

26 September 2018

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Cephalochromin, a FabI-directed antibacterial of microbial origin.

26 September 2018

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Structural basis of lipid biosynthesis regulation in Gram-positive bacteria

26 September 2018

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26 September 2018

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Type II fatty acid synthesis is not a suitable antibiotic target for Gram-positive pathogens

26 September 2018

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Crossref

https://api.crossref.org/works/10.1073/PNAS.1109208108

21 January 2018

Brinster et al. reply

1 reference

Crossref

https://api.crossref.org/works/10.1073/PNAS.1109208108

Erratum: A triclosan-resistant bacterial enzyme

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073/PNAS.1109208108

Enoyl-Acyl Carrier Protein Reductase (fabI) Plays a Determinant Role in Completing Cycles of Fatty Acid Elongation in Escherichia coli

21 January 2018

1 reference

12 December 2020

The soluble acyl-acyl carrier protein synthetase of Vibrio harveyi B392 is a member of the medium chain acyl-CoA synthetase family

1 reference

12 December 2020

Acyl-Phosphates Initiate Membrane Phospholipid Synthesis in Gram-Positive Pathogens

1 reference

12 December 2020

Where will new antibiotics come from?

1 reference

12 December 2020

Inhibition of fatty acid synthesis by the antibiotic cerulenin. Specific inactivation of beta-ketoacyl-acyl carrier protein synthetase

1 reference

12 December 2020

Construction of a vector for cloning promoters in Bacillus subtilis

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.1109208108

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21876172 AND SRC:MED&resulttype=core&format=json

11 February 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21876172 AND SRC:MED&resulttype=core&format=json

11 February 2020

PubMed publication ID

21876172

1 reference