Inhibition of the P2X7 receptor reduces cystogenesis in PKD. (Q35210209)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21636640 AND SRC:MED&resulttype=core&format=json

2 February 2020

title

Inhibition of the P2X7 receptor reduces cystogenesis in PKD (English)

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2 February 2020

1

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2 February 2020

author name string

Jenn-Kan Lu

2

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2 February 2020

Ya-Chung Tian

3

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2 February 2020

Yung-Chang Chen

4

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2 February 2020

Cheng-Chieh Hung

5

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2 February 2020

Yi-Hui Huang

6

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2 February 2020

Yau-Hung Chen

7

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2 February 2020

Mai-Szu Wu

8

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2 February 2020

Chih-Wei Yang

9

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2 February 2020

Yi-Chuan Cheng

10

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2 February 2020

publication date

2 June 2011

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Journal of the American Society of Nephrology

2 February 2020

published in

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2 February 2020

volume

22

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2 February 2020

issue

9

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2 February 2020

page(s)

1696-1706

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The ADPKD genes pkd1a/b and pkd2 regulate extracellular matrix formation

2 February 2020

cites work

1 reference

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Mammalian target of rapamycin regulates vascular endothelial growth factor-dependent liver cyst growth in polycystin-2-defective mice.

13 July 2018

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Drug screening for hearing loss: using the zebrafish lateral line to screen for drugs that prevent and cause hearing loss

13 July 2018

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P2X7-dependent release of interleukin-1beta and nociception in the spinal cord following lipopolysaccharide

13 July 2018

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Chemical modifier screen identifies HDAC inhibitors as suppressors of PKD models

13 July 2018

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P2X receptors: dawn of the post-structure era.

13 July 2018

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Characterization of P2X7 purinergic receptors and their function in rat lacrimal gland

13 July 2018

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ERK regulates renal cell proliferation and renal cyst expansion in inv mutant mice

13 July 2018

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Autosomal dominant polycystic kidney disease: the last 3 years

13 July 2018

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P2X7 deficiency attenuates renal injury in experimental glomerulonephritis

13 July 2018

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Attenuated, flow-induced ATP release contributes to absence of flow-sensitive, purinergic Cai2 signaling in human ADPKD cyst epithelial cells

13 July 2018

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Expression of H-RASV12 in a zebrafish model of Costello syndrome causes cellular senescence in adult proliferating cells

13 July 2018

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Cyst formation in kidney via B-Raf signaling in the PKD2 transgenic mice.

13 July 2018

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A tumor necrosis factor-alpha-mediated pathway promoting autosomal dominant polycystic kidney disease

13 July 2018

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P2X7 receptor as sensitive flow sensor for ERK activation in osteoblasts

13 July 2018

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Purinergic signaling in the lumen of a normal nephron and in remodeled PKD encapsulated cysts

13 July 2018

1 reference

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High-resolution in situ hybridization to whole-mount zebrafish embryos

13 July 2018

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Zebrafish mutations affecting cilia motility share similar cystic phenotypes and suggest a mechanism of cyst formation that differs from pkd2 morphants.

13 July 2018

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Innate immune gene expression in individual zebrafish after Listonella anguillarum inoculation

13 July 2018

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13 July 2018

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Hyperproliferation of PKD1 cystic cells is induced by insulin-like growth factor-1 activation of the Ras/Raf signalling system.

13 July 2018

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Polycystin-2 immunolocalization and function in zebrafish

13 July 2018

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P2X receptors as cell-surface ATP sensors in health and disease

13 July 2018

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Small molecule screening in the zebrafish

13 July 2018

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Antagonism of endogenous putative P2Y receptors reduces the growth of MDCK-derived cysts cultured in vitro

13 July 2018

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Characterization of ATP-gated P2X7 receptors in fish provides new insights into the mechanism of release of the leaderless cytokine interleukin-1 beta

13 July 2018

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Oxidized ATP protection against anthrax lethal toxin

13 July 2018

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Haploinsufficiency of Pkd2 is associated with increased tubular cell proliferation and interstitial fibrosis in two murine Pkd2 models.

13 July 2018

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Molecular characterization of the zebrafish P2X receptor subunit gene family.

13 July 2018

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P2X7 receptor activates extracellular signal-regulated kinases ERK1 and ERK2 independently of Ca2 influx

13 July 2018

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Cytokines in fluids from polycystic kidneys

13 July 2018

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Fluid Shear Stress Induces Renal Epithelial Gene Expression through Polycystin-2-Dependent Trafficking of Extracellular Regulated Kinase

13 July 2018

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The P2X7 receptor drives microglial activation and proliferation: a trophic role for P2X7R pore

26 September 2018

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Distinct functions for ERK1 and ERK2 in cell migration processes during zebrafish gastrulation.

26 September 2018

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Comparative expression of p2x receptors and ecto-nucleoside triphosphate diphosphohydrolase 3 in hypocretin and sensory neurons in zebrafish

26 September 2018

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The Wilms tumor genes wt1a and wt1b control different steps during formation of the zebrafish pronephros.

26 September 2018

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Zebrafish curly up encodes a Pkd2 ortholog that restricts left-side-specific expression of southpaw

26 September 2018

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Polaris and Polycystin-2 in dorsal forerunner cells and Kupffer's vesicle are required for specification of the zebrafish left-right axis

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3171940

The P2X7 ATP receptor modulates renal cyst development in vitro

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3171940

A genetic screen in zebrafish identifies cilia genes as a principal cause of cystic kidney

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3171940

P2X7 receptor inhibition improves recovery after spinal cord injury

26 September 2018

1 reference

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ATP release mechanisms in primary cultures of epithelia derived from the cysts of polycystic kidneys.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3171940

Autosomal dominant polycystic kidney disease: recent advances in pathogenesis and treatment

26 September 2018

1 reference

12 December 2020

cAMP stimulates the in vitro proliferation of renal cyst epithelial cells by activating the extracellular signal-regulated kinase pathway

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12 December 2020

Adenosine 5′ triphosphate evoked mobilization of intracellular calcium in central nervous system white matter of adult mouse optic nerve

1 reference

12 December 2020

P2X(7) receptors are expressed during mouse nephrogenesis and in collecting duct cysts of the cpk/cpk mouse

1 reference

12 December 2020

The P2X7 ATP receptor in the kidney: a matter of life or death?

1 reference

12 December 2020

Extracellular signal-regulated kinase inhibition slows disease progression in mice with polycystic kidney disease

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12 December 2020

Identifiers

DOI

10.1681/ASN.2010070728

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21636640 AND SRC:MED&resulttype=core&format=json

2 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21636640 AND SRC:MED&resulttype=core&format=json

2 February 2020

PubMed publication ID

21636640

1 reference