Polyamine metabolism and cancer. (Q35202801)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12927050 AND SRC:MED&resulttype=core&format=json

7 November 2019

review article

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title

Polyamine metabolism and cancer (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12927050 AND SRC:MED&resulttype=core&format=json

7 November 2019

author name string

Thresia Thomas

series ordinal

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12927050 AND SRC:MED&resulttype=core&format=json

7 November 2019

T J Thomas

series ordinal

2

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7 November 2019

publication date

1 April 2003

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Journal of Cellular and Molecular Medicine

7 November 2019

published in

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7 November 2019

volume

7

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7 November 2019

issue

2

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7 November 2019

page(s)

113-126

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Polyamines in cell growth and cell death: molecular mechanisms and therapeutic applications

7 November 2019

cites work

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Antizyme2 is a negative regulator of ornithine decarboxylase and polyamine transport

21 January 2018

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21 January 2018

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A polymorphic dinucleotide repeat in the rat nucleolin gene forms Z-DNA and inhibits promoter activity

21 January 2018

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Polyamine-mediated conformational perturbations in DNA alter the binding of estrogen receptor to poly(dG-m5dC).poly(dG-m5dC) and a plasmid containing the estrogen response element

21 January 2018

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Polyamines alter sequence-specific DNA-protein interactions

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Regulation of estrogenic and nuclear factor kappa B functions by polyamines and their role in polyamine analog-induced apoptosis of breast cancer cells

21 January 2018

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Influence of polyamines on DNA binding of heat shock and activator protein 1 transcription factors induced by heat shock.

21 January 2018

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Subunit- and site-specific pharmacology of the NMDA receptor channel

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Polyamines modulate the interaction between nuclear receptors and vitamin D receptor-interacting protein 205

21 January 2018

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Differentiation of PC12 cells induced by N8-acetylspermidine and by N8-acetylspermidine deacetylase inhibition

21 January 2018

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Effects of polyamines, polyamine synthesis inhibitors, and polyamine analogs on casein kinase II using Myc oncoprotein as substrate

21 January 2018

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Role of p42/p44 mitogen-activated-protein kinase and p21waf1/cip1 in the regulation of vascular smooth muscle cell proliferation by nitric oxide

21 January 2018

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p44/42 mitogen-activated protein kinase is involved in the expression of ornithine decarboxylase in leukaemia L1210 cells

21 January 2018

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Ornithine decarboxylase over-expression stimulates mitogen-activated protein kinase and anchorage-independent growth of human breast epithelial cells

21 January 2018

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Co-operation between follicular ornithine decarboxylase and v-Ha-ras induces spontaneous papillomas and malignant conversion in transgenic skin

21 January 2018

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Conversion of C57Bl/6 mice from a tumor promotion-resistant to a -sensitive phenotype by enhanced ornithine decarboxylase expression.

21 January 2018

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Disease model: familial adenomatous polyposis

21 January 2018

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APC-dependent regulation of ornithine decarboxylase in human colon tumor cells

21 January 2018

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ERCC2/XPD gene polymorphisms and cancer risk

21 January 2018

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Phase I trial of alpha-difluoromethyl ornithine (DFMO) and methylglyoxal bis (guanylhydrazone) (MGBG) in patients with advanced prostatic cancer

21 January 2018

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A phase I study of a new polyamine biosynthesis inhibitor, SAM486A, in cancer patients with solid tumours.

21 January 2018

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c-Jun activation-dependent tumorigenic transformation induced paradoxically by overexpression or block of S-adenosylmethionine decarboxylase

21 January 2018

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Use of aminopropyltransferase inhibitors and of non-metabolizable analogs to study polyamine regulation and function

21 January 2018

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Synthesis and biological evaluation of S-adenosyl-1,12-diamino-3-thio-9-azadodecane, a multisubstrate adduct inhibitor of spermine synthase

21 January 2018

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Effects of S-adenosyl-1,8-diamino-3-thio-octane and S-methyl-5'-methylthioadenosine on polyamine synthesis in Ehrlich ascites-tumour cells

21 January 2018

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Effects of inhibitors of spermidine synthase and spermine synthase on polyamine synthesis in rat tissues

21 January 2018

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Effect of S-adenosyl-1,12-diamino-3-thio-9-azadodecane, a multisubstrate adduct inhibitor of spermine synthase, on polyamine metabolism in mammalian cells

21 January 2018

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https://api.crossref.org/works/10.1111/J.1582-4934.2003.TB00210.X

Activation of polyamine catabolism in transgenic rats induces acute pancreatitis

21 January 2018

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Effects of polyamines, polyamine analogs, and inhibitors of protein synthesis on spermidine-spermine N1-acetyltransferase gene expression

21 January 2018

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Expression of SSAT, a novel biomarker of tubular cell damage, increases in kidney ischemia-reperfusion injury

21 January 2018

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Activation of polyamine catabolism profoundly alters tissue polyamine pools and affects hair growth and female fertility in transgenic mice overexpressing spermidine/spermine N1-acetyltransferase.

21 January 2018

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Altered levels of growth-related and novel gene transcripts in reproductive and other tissues of female mice overexpressing spermidine/spermine N1-acetyltransferase (SSAT).

21 January 2018

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Targeted expression of spermidine/spermine N1-acetyltransferase increases susceptibility to chemically induced skin carcinogenesis

21 January 2018

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Targeted disruption of spermidine/spermine N1-acetyltransferase gene in mouse embryonic stem cells. Effects on polyamine homeostasis and sensitivity to polyamine analogues

21 January 2018

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Genomic identification and biochemical characterization of the mammalian polyamine oxidase involved in polyamine back-conversion

21 January 2018

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Rapid induction of apoptosis by deregulated uptake of polyamine analogues

21 January 2018

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The role of polyamine catabolism in polyamine analogue-induced programmed cell death

21 January 2018

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Structure-function relationships in flavoenzyme-dependent amine oxidations: a comparison of polyamine oxidase and monoamine oxidase

21 January 2018

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Cloning and characterization of multiple human polyamine oxidase splice variants that code for isoenzymes with different biochemical characteristics

21 January 2018

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Inhibition of putrescine uptake by polypyridinium quaternary salts in B16 melanoma cells treated with difluoromethylornithine

21 January 2018

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Amino acid/spermine conjugates: polyamine amides as potent spermidine uptake inhibitors

21 January 2018

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The STK2 gene, which encodes a putative Ser/Thr protein kinase, is required for high-affinity spermidine transport in Saccharomyces cerevisiae

21 January 2018

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A second gene encoding a putative serine/threonine protein kinase which enhances spermine uptake in Saccharomyces cerevisiae.

21 January 2018

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Properties of a polyamine transporter regulated by antizyme

21 January 2018

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Polyamine transport in bacteria and yeast.

21 January 2018

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Antizyme, a mediator of ubiquitin-independent proteasomal degradation

21 January 2018

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Reduction of ornithine decarboxylase antizyme (ODC-Az) level in the 7,12-dimethylbenz(a)anthracene-induced hamster buccal pouch carcinogenesis model

21 January 2018

1 reference

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Interleukin-1-induced growth inhibition of human melanoma cells. Interleukin-1-induced antizyme expression is responsible for ornithine decarboxylase activity down-regulation

21 January 2018

1 reference

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Antizyme induction by polyamine analogues as a factor of cell growth inhibition

21 January 2018

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A second mammalian antizyme: conservation of programmed ribosomal frameshifting

21 January 2018

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Discovery of a spermatogenesis stage-specific ornithine decarboxylase antizyme: antizyme 3

21 January 2018

1 reference

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Novel synthetic polyamines are effective in the treatment of experimental microsporidiosis, an opportunistic AIDS-associated infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1582-4934.2003.TB00210.X

Polyamine structural effects on the induction and stabilization of liquid crystalline DNA: potential applications to DNA packaging, gene therapy and polyamine therapeutics

21 January 2018

1 reference

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Changes in gene expression in response to polyamine depletion indicates selective stabilization of mRNAs

21 January 2018

1 reference

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Transgenic mice with activated polyamine catabolism due to overexpression of spermidine/spermine N1-acetyltransferase show enhanced sensitivity to the polyamine analog, N1, N11-diethylnorspermine

21 January 2018

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12 December 2020

Polyamine biosynthesis inhibitors alter protein-protein interactions involving estrogen receptor in MCF-7 breast cancer cells

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12 December 2020

1-(N-alkylamino)-11-(N-ethylamino)-4,8-diazaundecanes: simple synthetic polyamine analogues that differentially alter tubulin polymerization

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12 December 2020

Characterization of the effects of polyamines on [125I]MK-801 binding to recombinant N-methyl-D-aspartate receptors

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12 December 2020

Synthesis of spermidine and norspermidine dimers as high affinity polyamine transport inhibitors

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12 December 2020

Polyamines. An overview

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The polyamine oxidase inhibitor MDL-72,527 selectively induces apoptosis of transformed hematopoietic cells through lysosomotropic effects

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12 December 2020

In vitro studies on the maintenance of transcription-induced stress by histones and polyamines

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12 December 2020

Sensitivity to polyamine-induced growth arrest correlates with antizyme induction in prostate carcinoma cells.

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12 December 2020

The chemical and biological versatility of riboflavin

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12 December 2020

Molecular correlates of the action of bis(ethyl)polyamines in breast cancer cell growth inhibition and apoptosis

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12 December 2020

Role of polyamines and NMDA receptors in ethanol dependence and withdrawal.

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12 December 2020

Polyamine transport system mediates agmatine transport in mammalian cells

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12 December 2020

Cloning and characterization of a human polyamine oxidase that is inducible by polyamine analogue exposure

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12 December 2020

Apoptotic signaling in polyamine analogue-treated SK-MEL-28 human melanoma cells.

1 reference

12 December 2020

Polyamine depletion in human melanoma cells leads to G1 arrest associated with induction of p21WAF1/CIP1/SDI1, changes in the expression of p21-regulated genes, and a senescence-like phenotype.

1 reference

12 December 2020

Deregulation of polyamine biosynthesis alters intrinsic histone acetyltransferase and deacetylase activities in murine skin and tumors.

1 reference

12 December 2020

Suppression of UV carcinogenesis by difluoromethylornithine in nucleotide excision repair-deficient Xpa knockout mice

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12 December 2020

A phase I and pharmacokinetic study of SAM486A, a novel polyamine biosynthesis inhibitor, administered on a daily-times-five every-three-week schedule in patients with Advanced solid malignancies.

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12 December 2020

The role of the cyclin-dependent kinase inhibitor p21 in apoptosis.

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12 December 2020

Development of polyamine analogs as cancer therapeutic agents

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12 December 2020

Spermidine nuclear acetylation in rat hepatocytes and in logarithmically growing rat hepatoma cells: comparison with histone acetylation

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12 December 2020

Mapping Z-DNA in the human genome. Computer-aided mapping reveals a nonrandom distribution of potential Z-DNA-forming sequences in human genes.

1 reference

12 December 2020

Effects of overexpression of ornithine decarboxylase (ODC) on growth control and oncogene-induced cell transformation

1 reference

12 December 2020

Putrescine or spermidine binding site of aminopropyltransferases and competitive inhibitors

1 reference

12 December 2020

Effects of a bis(benzyl)spermine analog on MCF-7 breast cancer cells in culture and nude mice xenografts

1 reference

12 December 2020

Microbial flora in the gastrointestinal tract abolishes cytostatic effects of alpha-difluoromethylornithine in vivo

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12 December 2020

Degradation of ornithine decarboxylase in reticulocyte lysate is ATP-dependent but ubiquitin-independent

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12 December 2020

Increased polyamines may downregulate interleukin 2 production in rheumatoid arthritis

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12 December 2020

Inhibition of mammalian spermine synthase by N-alkylated-1,3-diaminopropane derivatives in vitro and in cultured rat hepatoma cells

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12 December 2020

Regulation of polyamine biosynthetic activity by spermidine and spermine analogs--a novel antiproliferative strategy

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12 December 2020

Additive growth-inhibitory effects of DL-alpha-difluoromethylornithine and antiestrogens on MCF-7 breast cancer cell line

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12 December 2020

Polyamine metabolism and its importance in neoplastic growth and a target for chemotherapy

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12 December 2020

Functions of polyamine acetylation.

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12 December 2020

Structural specificity of polyamines in left-handed Z-DNA formation. Immunological and spectroscopic studies

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12 December 2020

Relative abilities of bis(ethyl) derivatives of putrescine, spermidine, and spermine to regulate polyamine biosynthesis and inhibit L1210 leukemia cell growth.

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12 December 2020

Structural alterations and stabilization of rabbit uterine estrogen receptors by natural polyamines

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12 December 2020

Effect of methylglyoxal bis(guanylhydrazone) on hepatic, heart and skeletal muscle mitochondrial carnitine palmitoyltransferase and beta-oxidation of fatty acids

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12 December 2020

Differential effects on the B-to-Z transition of poly(dG-me5dC).poly(dG-me5dC) produced by N1- and N8-acetyl spermidine

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12 December 2020

Interaction of paraquat and amine uptake by rat lungs perfused in situ

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12 December 2020

Methyl glyoxal bis(guanylhydrazone) as a potent inhibitor of mammalian and yeast S-adenosylmethionine decarboxylases

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12 December 2020

Induction of the polyamine-biosynthetic enzymes in mouse epidermis by tumor-promoting agents

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12 December 2020

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12 December 2020

Ornithine Decarboxylase as a Biological and Pharmacological Tool

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12 December 2020

Polyamine metabolism and function

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12 December 2020

Young Scientists Award lecture 1981: The identification of an accumulation system for diamines and polyamines into the lung and its relevance to paraquat toxicity.

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12 December 2020

Serum polyamine-oxidase activity in spontaneous abortion

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12 December 2020

Synthesis and evaluation of some stable multisubstrate adducts as specific inhibitors of spermidine synthase

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12 December 2020

Life‐long over‐expression of ornithine decarboxylase (ODC) gene in transgenic mice does not lead to generally enhanced tumorigenesis or neuronal degeneration

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12 December 2020

Polyamines as targets for therapeutic intervention

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12 December 2020

Antiproliferative effect of spermine depletion by N-cyclohexyl-1,3-diaminopropane in human breast cancer cells.

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12 December 2020

Regulation of cyclin B1 by estradiol and polyamines in MCF-7 breast cancer cells.

1 reference

12 December 2020

Transformation of NIH/3T3 cells by ornithine decarboxylase overexpression.

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12 December 2020

Spermidine/spermine N1-acetyltransferase--the turning point in polyamine metabolism

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12 December 2020

Polyamine oxidase, properties and functions

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12 December 2020

The potential of a novel polyamine transport inhibitor in cancer chemotherapy

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12 December 2020

2,2'-Dithiobis(N-ethyl-spermine-5-carboxamide) is a high affinity, membrane-impermeant antagonist of the mammalian polyamine transport system

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12 December 2020

Bis(7-amino-4-azaheptyl)dimethlysilane and bis(7-ethylamino-4-azaheptyl)dimethylsilane: inhibition of tumor cell growth in vitro and in vivo

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12 December 2020

Comparative molecular field analysis-based predictive model of structure-function relationships of polyamine transport inhibitors in L1210 cells

1 reference

12 December 2020

Ornithine decarboxylase overexpression is a sufficient condition for tumor promotion in mouse skin.

1 reference

12 December 2020

Human ornithine decarboxylase-overproducing NIH3T3 cells induce rapidly growing, highly vascularized tumors in nude mice.

1 reference

12 December 2020

Induction of spermidine/spermine N1-acetyltransferase in human cancer cells in response to increased production of reactive oxygen species

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12 December 2020

Polyamines and cerebral ischemia

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12 December 2020

The gastrointestinal polyamine source depletion enhances DFMO induced polyamine depletion in MCF-7 human breast cancer cells in vivo

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12 December 2020

A randomized, placebo-controlled trial of low-dose alpha-difluoromethylornithine in individuals at risk for colorectal cancer.

1 reference

12 December 2020

10.1111/J.1582-4934.2003.TB00210.X

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12927050 AND SRC:MED&resulttype=core&format=json

7 November 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12927050 AND SRC:MED&resulttype=core&format=json

7 November 2019

PubMed publication ID

12927050

1 reference