The PPAR-γ agonist pioglitazone modulates inflammation and induces neuroprotection in parkinsonian monkeys (Q35196195)

7 August 2017

title

The PPAR-γ agonist pioglitazone modulates inflammation and induces neuroprotection in parkinsonian monkeys (English)

1 reference

7 August 2017

1 reference

1 reference

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9 December 2024

9

Marina E Emborg

1 reference

7 August 2017

2

Valerie Joers

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:21819568

9 December 2024

7

Joseph W. Kemnitz

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9 December 2024

author name string

Viktoriya Bondarenko

3

1 reference

7 August 2017

Kevin Brunner

4

1 reference

7 August 2017

Christine R. Swanson

1

1 reference

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9 December 2024

Heather A. Simmons

5

1 reference

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9 December 2024

Toni E. Ziegler

6

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9 December 2024

Jeffrey A. Johnson

8

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9 December 2024

language of work or name

English

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National Center for Biotechnology Information

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9 December 2024

publication date

5 August 2011

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full work available at URL

7 August 2017

https://jneuroinflammation.biomedcentral.com/counter/pdf/10.1186/1742-2094-8-91

Portable Document Format

online access status

open access

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:21819568

https://europepmc.org/articles/PMC3166925

9 December 2024

HyperText Markup Language

online access status

open access

content deliverer

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:21819568

https://europepmc.org/articles/PMC3166925?pdf=render

9 December 2024

Portable Document Format

online access status

open access

content deliverer

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:21819568

https://link.springer.com/content/pdf/10.1186/1742-2094-8-91.pdf

9 December 2024

Portable Document Format

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Journal of Neuroinflammation

9 December 2024

published in

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7 August 2017

volume

8

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7 August 2017

page(s)

91

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describes a project that uses

7 August 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3166925/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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13 July 2018

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The PPARgamma agonist pioglitazone is effective in the MPTP mouse model of Parkinson's disease through inhibition of monoamine oxidase B.

13 July 2018

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Protective properties afforded by pioglitazone against intrastriatal LPS in Sprague-Dawley rats

13 July 2018

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13 July 2018

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Effect of pioglitazone treatment on behavioral symptoms in autistic children

13 July 2018

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Realistic expectations for treatment success in Alzheimer's disease

13 July 2018

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Basal ganglia lesions after MPTP administration in rhesus monkeys

13 July 2018

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Receptor-independent actions of PPAR thiazolidinedione agonists: is mitochondrial function the key?

13 July 2018

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Evaluation of animal models of Parkinson's disease for neuroprotective strategies

13 July 2018

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Effects of peroxisome proliferator-activated receptor agonists on LPS-induced neuronal death in mixed cortical neurons: associated with iNOS and COX-2.

13 July 2018

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13 July 2018

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Peroxisome proliferator-activated receptors in inflammation control

13 July 2018

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13 July 2018

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Differences in the metabolism of MPTP in the rodent and primate parallel differences in sensitivity to its neurotoxic effects

13 July 2018

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The pharmacology of the parkinsonian syndrome producing neurotoxin MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) and structurally related compounds

13 July 2018

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Administration of MPTP acutely increases glucose utilization in the substantia nigra of primates.

13 July 2018

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Metabolism of [14C]MPTP in mouse and monkey implicates MPP , and not bound metabolites, as the operative neurotoxin

13 July 2018

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The absolute number of nerve cells in substantia nigra in normal subjects and in patients with Parkinson's disease estimated with an unbiased stereological method

13 July 2018

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Treatment of insulin-resistant mice with the oral antidiabetic agent pioglitazone: evaluation of liver GLUT2 and phosphoenolpyruvate carboxykinase expression

13 July 2018

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13 July 2018

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Protective action of the peroxisome proliferator-activated receptor-gamma agonist pioglitazone in a mouse model of Parkinson's disease.

21 January 2018

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21 January 2018

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21 January 2018

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PET studies of functional compensation in a primate model of Parkinsonʼs disease

21 January 2018

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Acute administration of 1-N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), a compound producing parkinsonism in humans, stimulates [2-14C]deoxyglucose uptake in the regions of the catecholaminergic cell bodies in the rat and guinea pig brains

21 January 2018

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21 January 2018

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Peroxisome proliferator-activated receptor-gamma agonists prevent experimental autoimmune encephalomyelitis

21 January 2018

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The oral antidiabetic pioglitazone protects from neurodegeneration and amyotrophic lateral sclerosis-like symptoms in superoxide dismutase-G93A transgenic mice.

21 January 2018

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Ameliorative effect of pioglitazone on seizure responses in genetically epilepsy-susceptible EL mice

21 January 2018

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Pioglitazone exerts protective effects against stroke in stroke-prone spontaneously hypertensive rats, independently of blood pressure

21 January 2018

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A pilot test of pioglitazone as an add-on in patients with relapsing remitting multiple sclerosis.

21 January 2018

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Effects of pioglitazone on diffusion tensor imaging indices in multiple sclerosis patients

21 January 2018

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Neuroprotective effects of pioglitazone in a rat model of permanent focal cerebral ischemia are associated with peroxisome proliferator-activated receptor gamma-mediated suppression of nuclear factor-κB signaling pathway

21 January 2018

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26 September 2018

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Acute treatment with the PPARgamma agonist pioglitazone and ibuprofen reduces glial inflammation and Abeta1-42 levels in APPV717I transgenic mice

26 September 2018

1 reference

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Protection by pioglitazone in the MPTP model of Parkinson's disease correlates with I kappa B alpha induction and block of NF kappa B and iNOS activation.

26 September 2018

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Effect of pioglitazone on abdominal fat distribution and insulin sensitivity in type 2 diabetic patients

26 September 2018

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26 September 2018

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Pioglitazone increases insulin sensitivity, reduces blood glucose, insulin, and lipid levels, and lowers blood pressure, in obese, insulin-resistant rhesus monkeys

26 September 2018

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Effects of pioglitazone on glucose and lipid metabolism in normal and insulin resistant animals.

26 September 2018

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In vivo PET studies of the dopamine D2 receptors in rhesus monkeys with long-term MPTP-induced parkinsonism

26 September 2018

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12 December 2020

Mechanism of neuroprotective action of the anti-Parkinson drug rasagiline and its derivatives

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High-performance liquid chromatographic method for the determination of pioglitazone in human plasma using ultraviolet detection and its application to a pharmacokinetic study

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12 December 2020

A call for clinically driven experimental design in assessing neuroprotection in experimental Parkinsonism

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12 December 2020

Thiazolidinedione class of peroxisome proliferator-activated receptor gamma agonists prevents neuronal damage, motor dysfunction, myelin loss, neuropathic pain, and inflammation after spinal cord injury in adult rats

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12 December 2020

A model of experimental autoimmune encephalomyelitis (EAE) in C57BL/6 mice for the characterisation of intervention therapies

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12 December 2020

Estimation of the number of somatostatin neurons in the striatum: an in situ hybridization study using the optical fractionator method

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12 December 2020

MPTP-Induced hemiparkinsonism in nonhuman primates 6-8 years after a single unilateral intracarotid dose

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12 December 2020

Pioglitazone enhances splanchnic glucose uptake as well as peripheral glucose uptake in non-insulin-dependent diabetes mellitus. AD-4833 Clamp-OGL Study Group

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12 December 2020

Parkinson's Disease and Systemic Inflammation

3

1 reference

https://api.crossref.org/works/10.1186/1742-2094-8-91

9 December 2024

Experimental Neurology

20

152

829

ME Emborg-Knott

1998

1 reference

https://api.crossref.org/works/10.1186/1742-2094-8-91

9 December 2024

Identifiers

1 reference

Dimensions Publication ID

7 August 2017

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1 reference

7 August 2017

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