Why Human Cytochrome P450c21 Is a Progesterone 21-Hydroxylase (Q35190481)

7 August 2017

title

Why human cytochrome P450c21 is a progesterone 21-hydroxylase (English)

1 reference

7 August 2017

Why Human Cytochrome P450c21 Is a Progesterone 21-Hydroxylase (English)

1 reference

28 November 2024

author name string

Dario Mizrachi

1

1 reference

7 August 2017

Zhu Wang

2

1 reference

7 August 2017

Keliang Xu

5

1 reference

7 August 2017

Kamalesh K. Sharma

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:21446712

28 November 2024

Manisha K. Gupta

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:21446712

28 November 2024

Christopher R. Dwyer

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:21446712

28 November 2024

Richard J. Auchus

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:21446712

28 November 2024

language of work or name

English

0 references

publication date

21 April 2011

1 reference

full work available at URL

7 August 2017

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3165045

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https://europepmc.org/articles/pmc3165045?pdf=render

file format

Portable Document Format

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:21446712

https://europepmc.org/articles/PMC3165045

28 November 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:21446712

https://europepmc.org/articles/PMC3165045?pdf=render

28 November 2024

file format

Portable Document Format

online access status

open access

content deliverer

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:21446712

https://doi.org/10.1021/bi102078e

28 November 2024

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:21446712

https://pubs.acs.org/doi/pdf/10.1021/bi102078e

28 November 2024

1 reference

28 November 2024

1 reference

7 August 2017

volume

50

1 reference

7 August 2017

issue

19

1 reference

7 August 2017

page(s)

3968-3974

1 reference

The Molecular Biology, Biochemistry, and Physiology of Human Steroidogenesis and Its Disorders

7 August 2017

cites work

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New insights into the structural features and functional relevance of human cytochrome P450 2C9. Part I.

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A single amino acid residue, Ala 105, confers 16alpha-hydroxylase activity to human cytochrome P450 17alpha-hydroxylase/17,20 lyase

13 July 2018

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The ins and outs of cytochrome P450s.

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CYP17 Mutation E305G Causes Isolated 17,20-Lyase Deficiency by Selectively Altering Substrate Binding

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The enantiomer of progesterone (ent-progesterone) is a competitive inhibitor of human cytochromes P450c17 and P450c21.

13 July 2018

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Analysis of mammalian cytochrome P450 structure and function by site-directed mutagenesis

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The genetics, pathophysiology, and management of human deficiencies of P450c17.

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Congenital adrenal hyperplasia due to 21-hydroxylase deficiency

13 July 2018

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Mammalian microsomal cytochrome P450 monooxygenase: structural adaptations for membrane binding and functional diversity

13 July 2018

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Molecular modeling of human P450c17 (17alpha-hydroxylase/17,20-lyase): insights into reaction mechanisms and effects of mutations.

13 July 2018

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Results of screening 1.9 million Texas newborns for 21-hydroxylase-deficient congenital adrenal hyperplasia.

13 July 2018

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Cytochrome b5 augments the 17,20-lyase activity of human P450c17 without direct electron transfer

13 July 2018

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Progesterone and testosterone hydroxylation by cytochromes P450 2C19, 2C9, and 3A4 in human liver microsomes

13 July 2018

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Progesterone 16 alpha-hydroxylase activity is catalyzed by human cytochrome P450 17 alpha-hydroxylase

13 July 2018

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Substitution at residue 473 confers progesterone 21-hydroxylase activity to cytochrome P450 2C2.

13 July 2018

1 reference

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Role of cytochromes P-450 in the biosynthesis of steroid hormones.

13 July 2018

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Expression of bovine 17 alpha-hydroxylase cytochrome P-450 cDNA in nonsteroidogenic (COS 1) cells

13 July 2018

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Cloning and sequence of the human gene for P450c17 (steroid 17 alpha-hydroxylase/17,20 lyase): similarity with the gene for P450c21

13 July 2018

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Expression of a full-length cDNA encoding bovine adrenal cytochrome P450C21.

13 July 2018

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A hypervariable region of P450IIC5 confers progesterone 21-hydroxylase activity to P450IIC1.

13 July 2018

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Clinical and Molecular Genetics of Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency

13 July 2018

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Genotype of Yupik Eskimos with congenital adrenal hyperplasia due to 21-hydroxylase deficiency

13 July 2018

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Human cytochromes P450: problems and prospects

13 July 2018

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Molecular model of human CYP21 based on mammalian CYP2C5: structural features correlate with clinical severity of mutations causing congenital adrenal hyperplasia

13 July 2018

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The development of an efficient system for heterologous expression of cytochrome P450s in Escherichia coli using hemA gene co-expression

27 September 2018

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Functional characterization of two novel point mutations in the CYP21 gene causing simple virilizing forms of congenital adrenal hyperplasia due to 21-hydroxylase deficiency

27 September 2018

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5α-reduced C21 steroids are substrates for human cytochrome P450c17

27 September 2018

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Sequence alignments, variabilities, and vagaries.

27 September 2018

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Expression and purification of functional human 17 alpha-hydroxylase/17,20-lyase (P450c17) in Escherichia coli. Use of this system for study of a novel form of combined 17 alpha-hydroxylase/17,20-lyase deficiency

27 September 2018

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Identifiers

DOI

10.1021/BI102078E

1 reference

7 August 2017

1 reference

7 August 2017

1 reference