Caveolae: mining little caves for new cancer targets (Q35190153)

7 August 2017

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title

Caveolae: mining little caves for new cancer targets (English)

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7 August 2017

Lucy A Carver

1

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7 August 2017

Jan E Schnitzer

series ordinal

2

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7 August 2017

language of work or name

English

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publication date

1 August 2003

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7 August 2017

published in

Nature Reviews Cancer

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7 August 2017

volume

3

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7 August 2017

issue

8

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7 August 2017

page(s)

571-581

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Endothelial plasmalemmal vesicles have a characteristic striped bipolar surface structure

7 August 2017

cites work

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Caveolin, a protein component of caveolae membrane coats

31 March 2020

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VIP21/caveolin is a cholesterol-binding protein

31 March 2020

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Separation of Caveolae from Associated Microdomains of GPI-Anchored Proteins

31 March 2020

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A role for lipid shells in targeting proteins to caveolae, rafts, and other lipid domains

31 March 2020

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Segregation of heterotrimeric G proteins in cell surface microdomains. G(q) binds caveolin to concentrate in caveolae, whereas G(i) and G(s) target lipid rafts by default

31 March 2020

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Organized endothelial cell surface signal transduction in caveolae distinct from glycosylphosphatidylinositol-anchored protein microdomains

31 March 2020

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Localization of platelet-derived growth factor-stimulated phosphorylation cascade to caveolae

31 March 2020

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Rapid mechanotransduction in situ at the luminal cell surface of vascular endothelium and its caveolae

31 March 2020

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In situ flow activates endothelial nitric oxide synthase in luminal caveolae of endothelium with rapid caveolin dissociation and calmodulin association

31 March 2020

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Dissecting the interaction between nitric oxide synthase (NOS) and caveolin. Functional significance of the nos caveolin binding domain in vivo

31 March 2020

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Src tyrosine kinases, Galpha subunits, and H-Ras share a common membrane-anchored scaffolding protein, caveolin. Caveolin binding negatively regulates the auto-activation of Src tyrosine kinases

31 March 2020

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Endothelial nitric oxide synthase is regulated by tyrosine phosphorylation and interacts with caveolin-1

31 March 2020

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Endothelial nitric oxide synthase targeting to caveolae. Specific interactions with caveolin isoforms in cardiac myocytes and endothelial cells

31 March 2020

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Caveolin-1 regulates shear stress-dependent activation of extracellular signal-regulated kinase

31 March 2020

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Reciprocal regulation of endothelial nitric-oxide synthase by Ca2 -calmodulin and caveolin

31 March 2020

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In vivo delivery of the caveolin-1 scaffolding domain inhibits nitric oxide synthesis and reduces inflammation

31 March 2020

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Loss of caveolae, vascular dysfunction, and pulmonary defects in caveolin-1 gene-disrupted mice

31 March 2020

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Caveolin-1 regulates transforming growth factor (TGF)-beta/SMAD signaling through an interaction with the TGF-beta type I receptor

31 March 2020

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Filipin-sensitive caveolae-mediated transport in endothelium: reduced transcytosis, scavenger endocytosis, and capillary permeability of select macromolecules

31 March 2020

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Plasma membrane cholesterol is a key molecule in shear stress-dependent activation of extracellular signal-regulated kinase

31 March 2020

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Non-coated membrane invaginations are involved in binding and internalization of cholera and tetanus toxins

31 March 2020

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Role of GTP hydrolysis in fission of caveolae directly from plasma membranes

31 March 2020

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Caveolae: from basic trafficking mechanisms to targeting transcytosis for tissue-specific drug and gene delivery in vivo

31 March 2020

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Rab proteins mediate Golgi transport of caveola-internalized glycosphingolipids and correct lipid trafficking in Niemann-Pick C cells

31 March 2020

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Caveolin cycles between plasma membrane caveolae and the Golgi complex by microtubule-dependent and microtubule-independent steps

31 March 2020

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Caveolin moves from caveolae to the Golgi apparatus in response to cholesterol oxidation

31 March 2020

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Distinct caveolae-mediated endocytic pathways target the Golgi apparatus and the endoplasmic reticulum

31 March 2020

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Clathrin-dependent and -independent internalization of plasma membrane sphingolipids initiates two Golgi targeting pathways

31 March 2020

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Endocytosis of simian virus 40 into the endoplasmic reticulum

31 March 2020

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Caveolar endocytosis of simian virus 40 reveals a new two-step vesicular-transport pathway to the ER

31 March 2020

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Localization of autocrine motility factor receptor to caveolae and clathrin-independent internalization of its ligand to smooth endoplasmic reticulum

31 March 2020

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Ligands internalized through coated or noncoated invaginations follow a common intracellular pathway

31 March 2020

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Dynamin at the neck of caveolae mediates their budding to form transport vesicles by GTP-driven fission from the plasma membrane of endothelium

31 March 2020

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Endothelial caveolae have the molecular transport machinery for vesicle budding, docking, and fusion including VAMP, NSF, SNAP, annexins, and GTPases

31 March 2020

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Transcytosis in the continuous endothelium of the myocardial microvasculature is inhibited by N-ethylmaleimide

31 March 2020

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Nucleotide-dependent conformational changes in dynamin: evidence for a mechanochemical molecular spring

31 March 2020

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Dynamin-mediated internalization of caveolae.

31 March 2020

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Sequestration of GPI-anchored proteins in caveolae triggered by cross-linking

31 March 2020

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GPI-anchored proteins, glycosphingolipids, and sphingomyelin are sequestered to caveolae only after crosslinking

31 March 2020

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Update on the cellular and molecular basis of capillary permeability

31 March 2020

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Targeting endothelium and its dynamic caveolae for tissue-specific transcytosis in vivo: a pathway to overcome cell barriers to drug and gene delivery

31 March 2020

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Structure and function of sphingolipid- and cholesterol-rich membrane rafts

31 March 2020

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Immunoisolation of caveolae with high affinity antibody binding to the oligomeric caveolin cage. Toward understanding the basis of purification.

31 March 2020

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Glycolipid-anchored proteins in neuroblastoma cells form detergent-resistant complexes without caveolin

31 March 2020

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Induction of caveolae in the apical plasma membrane of Madin-Darby canine kidney cells

31 March 2020

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Endocytosis of GPI-anchored proteins in human lymphocytes: role of glycolipid-based domains, actin cytoskeleton, and protein kinases

31 March 2020

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Placental alkaline phosphatase, a GPI-anchored protein, is clustered in clathrin-coated vesicles

31 March 2020

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GPI-anchored proteins are delivered to recycling endosomes via a distinct cdc42-regulated, clathrin-independent pinocytic pathway.

31 March 2020

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Tumor cell growth inhibition by caveolin re-expression in human breast cancer cells

31 March 2020

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Recombinant expression of caveolin-1 in oncogenically transformed cells abrogates anchorage-independent growth

31 March 2020

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Caveolin-1 inhibits epidermal growth factor-stimulated lamellipod extension and cell migration in metastatic mammary adenocarcinoma cells (MTLn3). Transformation suppressor effects of adenovirus-mediated gene delivery of caveolin-1.

31 March 2020

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Caveolin-1 inhibits anchorage-independent growth, anoikis and invasiveness in MCF-7 human breast cancer cells

31 March 2020

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Caveolin-1 expression sensitizes fibroblastic and epithelial cells to apoptotic stimulation

31 March 2020

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Targeted downregulation of caveolin-1 is sufficient to drive cell transformation and hyperactivate the p42/44 MAP kinase cascade

31 March 2020

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Caveolin-1, a putative tumour suppressor gene

31 March 2020

2 references

31 March 2020

inferred from DOI database lookup

7 January 2021

based on heuristic

Tyrosine phosphorylation of caveolin-1 in the endothelium

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Reduction of caveolin and caveolae in oncogenically transformed cells

31 March 2020

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Reciprocal regulation of neu tyrosine kinase activity and caveolin-1 protein expression in vitro and in vivo. Implications for human breast cancer

31 March 2020

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Caveolin-1 is down-regulated in human ovarian carcinoma and acts as a candidate tumor suppressor gene

31 March 2020

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Down-regulation of caveolin-1, a candidate tumor suppressor gene, in sarcomas

31 March 2020

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Caveolin 1-mediated regulation of receptor tyrosine kinase-associated phosphatidylinositol 3-kinase activity by ceramide

31 March 2020

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Chromosomal localization, genomic organization, and developmental expression of the murine caveolin gene family (Cav-1, -2, and -3). Cav-1 and Cav-2 genes map to a known tumor suppressor locus (6-A2/7q31).

31 March 2020

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Hypermethylation of the caveolin-1 gene promoter in prostate cancer

31 March 2020

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Analysis of the CAVEOLIN-1 gene at human chromosome 7q31.1 in primary tumours and tumour-derived cell lines

31 March 2020

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Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

31 March 2020

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Effects of an Rb mutation in the mouse

31 March 2020

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Loss of Apc heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncated Apc gene

31 March 2020

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Defects in caveolin-1 cause dilated cardiomyopathy and pulmonary hypertension in knockout mice

31 March 2020

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Caveolin-1 mutations (P132L and null) and the pathogenesis of breast cancer: caveolin-1 (P132L) behaves in a dominant-negative manner and caveolin-1 (-/-) null mice show mammary epithelial cell hyperplasia

31 March 2020

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Loss of caveolin-1 gene expression accelerates the development of dysplastic mammary lesions in tumor-prone transgenic mice

31 March 2020

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Caveolin-1 is regulated by c-myc and suppresses c-myc-induced apoptosis

31 March 2020

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Up-regulation of caveolae and caveolar constituents in multidrug-resistant cancer cells

31 March 2020

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Caveolin-1 expression is associated with high-grade bladder cancer

31 March 2020

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Overexpression of caveolin-1 in esophageal squamous cell carcinoma correlates with lymph node metastasis and pathologic stage

31 March 2020

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Identification of caveolin-1 in lipoprotein particles secreted by exocrine cells

31 March 2020

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Upregulation of caveolin in multidrug resistant cancer cells: functional implications

31 March 2020

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Intrasarcolemmal Proliferation of the VX2 Carcinoma

31 March 2020

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Angiogenesis in cancer and other diseases

31 March 2020

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Induction of angiogenesis during the transition from hyperplasia to neoplasia

31 March 2020

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The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor

31 March 2020

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High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis

31 March 2020

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VEGF and the quest for tumour angiogenesis factors

31 March 2020

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Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid

31 March 2020

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Microvascular hyperpermeability in caveolin-1 (-/-) knock-out mice. Treatment with a specific nitric-oxide synthase inhibitor, L-NAME, restores normal microvascular permeability in Cav-1 null mice

31 March 2020

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Predominant role of endothelial nitric oxide synthase in vascular endothelial growth factor-induced angiogenesis and vascular permeability

31 March 2020

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Vesiculo-vacuolar organelles and the regulation of venule permeability to macromolecules by vascular permeability factor, histamine, and serotonin

31 March 2020

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Caveolae and vesiculo-vacuolar organelles in bovine capillary endothelial cells cultured with VPF/VEGF on floating Matrigel-collagen gels

31 March 2020

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Colocalization prostacyclin (PGI2) synthase--caveolin-1 in endothelial cells and new roles for PGI2 in angiogenesis.

31 March 2020

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Mechanisms of normal and tumor-derived angiogenesis

31 March 2020

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Caveolin-1 expression enhances endothelial capillary tubule formation

31 March 2020

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Angiogenesis activators and inhibitors differentially regulate caveolin-1 expression and caveolae formation in vascular endothelial cells. Angiogenesis inhibitors block vascular endothelial growth factor-induced down-regulation of caveolin-1.

31 March 2020

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Regulation of vascular endothelial growth factor receptor-2 activity by caveolin-1 and plasma membrane cholesterol.

31 March 2020

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Vascular targeting as a strategy for cancer therapy

31 March 2020

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Vascular targeting--a new approach to the therapy of solid tumors

31 March 2020

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31 March 2020

Immunotoxins: an update

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Barriers to drug delivery in solid tumors

31 March 2020

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The fine structure of the gall bladder epithelium of the mouse.

31 March 2020

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Endothelial plasmalemmal vesicles as elements in a system of branching invaginations from the cell surface

31 March 2020

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The endothelial vesicle system in cryofixed frog mesenteric capillaries analysed by ultrathin serial sectioning

31 March 2020

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Fluid and protein fluxes across small and large pores in the microvasculature. Application of two-pore equations

31 March 2020

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Dynamic activation of endothelial nitric oxide synthase by Hsp90.

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRC1146

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Dimensions Publication ID

7 August 2017

1046310421

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