Progestin and antiprogestin responsiveness in breast cancer is driven by the PRA/PRB ratio via AIB1 or SMRT recruitment to the CCND1 and MYC promoters. (Q35181201)

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English	Progestin and antiprogestin responsiveness in breast cancer is driven by the PRA/PRB ratio via AIB1 or SMRT recruitment to the CCND1 and MYC promoters.	scientific article

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22 February 2020

Progestin and antiprogestin responsiveness in breast cancer is driven by the PRA/PRB ratio via AIB1 or SMRT recruitment to the CCND1 and MYC promoters (English)

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22 February 2020

Sebastián Giulianelli

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22 February 2020

Britta Jacobsen

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22 February 2020

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Claudia Lanari

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22 February 2020

Alfredo A Molinolo

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Alfredo Molinolo

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22 February 2020

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Victoria Wargon

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22 February 2020

Marina Riggio

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22 February 2020

Gonzalo R Sequeira

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22 February 2020

Paola Rojas

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22 February 2020

María May

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22 February 2020

María L Polo

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22 February 2020

María A Gorostiaga

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22 February 2020

Virginia Novaro

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22 February 2020

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12 November 2014

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22 February 2020

International Journal of Cancer

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22 February 2020

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22 February 2020

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22 February 2020

2680-2692

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22 February 2020

Novel, low cost, highly effective, handmade steroid pellets for experimental studies

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Differential regulation of breast cancer-associated genes by progesterone receptor isoforms PRA and PRB in a new bi-inducible breast cancer cell line

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Estrogen receptor alpha mediates progestin-induced mammary tumor growth by interacting with progesterone receptors at the cyclin D1/MYC promoters

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13 July 2018

Antiprogestins in breast cancer treatment: are we ready?

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Antiprogestin mifepristone inhibits the growth of cancer cells of reproductive and non-reproductive origin regardless of progesterone receptor expression.

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Interaction between FGFR-2, STAT5, and progesterone receptors in breast cancer.

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13 July 2018

CDB-4124, a Progesterone Receptor Modulator, Inhibits Mammary Carcinogenesis by Suppressing Cell Proliferation and Inducing Apoptosis

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Hypermethylation of the progesterone receptor A in constitutive antiprogestin-resistant mouse mammary carcinomas.

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Cooperative activation of cyclin D1 and progesterone receptor gene expression by the SRC-3 coactivator and SMRT corepressor

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Progesterone action in human tissues: regulation by progesterone receptor (PR) isoform expression, nuclear positioning and coregulator expression

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Nuclear receptor coregulators in cancer biology

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Positive association between nuclear Runx2 and oestrogen-progesterone receptor gene expression characterises a biological subtype of breast cancer.

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The MPA mouse breast cancer model: evidence for a role of progesterone receptors in breast cancer.

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Progesterone receptor action: translating studies in breast cancer models to clinical insights

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ER alpha negative breast cancer cells restore response to endocrine therapy by combination treatment with both HDAC inhibitor and DNMT inhibitor

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13 July 2018

Progestins reinitiate cell cycle progression in antiestrogen-arrested breast cancer cells through the B-isoform of progesterone receptor

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A structural and in vitro characterization of asoprisnil: a selective progesterone receptor modulator

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Direct observation of individual endogenous protein complexes in situ by proximity ligation

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Breast cancer patients with progesterone receptor PR-A-rich tumors have poorer disease-free survival rates

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Three novel hormone-responsive cell lines derived from primary human breast carcinomas: functional characterization.

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13 July 2018

Defective mammary gland morphogenesis in mice lacking the progesterone receptor B isoform

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Unfolding the action of progesterone receptors

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13 July 2018

Role of the estrogen receptor coactivator AIB1 (SRC-3) and HER-2/neu in tamoxifen resistance in breast cancer

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Coactivator/corepressor ratios modulate PR-mediated transcription by the selective receptor modulator RU486

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CDB-4124 and its putative monodemethylated metabolite, CDB-4453, are potent antiprogestins with reduced antiglucocorticoid activity: in vitro comparison to mifepristone and CDB-2914.

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The opposing transcriptional activities of the two isoforms of the human progesterone receptor are due to differential cofactor binding

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Differential gene regulation by the two progesterone receptor isoforms in human breast cancer cells

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Breast cancer and hormone-replacement therapy: the Million Women Study

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RAC3 overexpression is a transforming and proliferative signal that contributes to tumoral development

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Progesterone receptor isoforms, PR-B and PR-A, in breast cancer: correlations with clinicopathologic tumor parameters and expression of AP-1 factors

1 reference

https://pubmed.ncbi.nlm.nih.gov/25363551

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of the progestin antagonist RU 486 on T-47D breast cancer cell cycle kinetics and cell cycle regulatory genes

1 reference

https://pubmed.ncbi.nlm.nih.gov/25363551

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of progesterone receptor A and B expression in human breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/25363551

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Progesterone receptor isoforms in normal and malignant breast

1 reference

https://pubmed.ncbi.nlm.nih.gov/25363551

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1002/IJC.29304

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25363551 AND SRC:MED&resulttype=core&format=json

22 February 2020

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22 February 2020

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Europe PubMed Central

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22 February 2020

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