Misfolded PrP impairs the UPS by interaction with the 20S proteasome and inhibition of substrate entry (Q35177001)

6 August 2017

title

Misfolded PrP impairs the UPS by interaction with the 20S proteasome and inhibition of substrate entry (English)

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6 August 2017

13

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6 August 2017

Pelagia Deriziotis

1

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James A Nathan

James A Nathan

7

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David M. Smith

David M Smith

3

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Michael H Glickman

Michael H Glickman

10

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John Collinge

11

John Collinge

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6 August 2017

8

Rina Rosenzweig

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6 August 2017

Ralph André

2

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6 August 2017

Rob Goold

4

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6 August 2017

Kerri J Kinghorn

5

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6 August 2017

Mark Kristiansen

6

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6 August 2017

Dasha Krutauz

9

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6 August 2017

Alfred L Goldberg

12

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6 August 2017

language of work or name

English

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publication date

8 July 2011

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6 August 2017

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6 August 2017

volume

30

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6 August 2017

issue

15

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6 August 2017

page(s)

3065-3077

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Expression of mutant or cytosolic PrP in transgenic mice and cells is not associated with endoplasmic reticulum stress or proteasome dysfunction

6 August 2017

cites work

1 reference

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Ubiquitinated proteins activate the proteasome by binding to Usp14/Ubp6, which causes 20S gate opening

28 July 2018

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A tetrahedral transition state at the active sites of the 20S proteasome is coupled to opening of the alpha-ring channel

28 July 2018

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Variably modulated gating of the 26S proteasome by ATP and polyubiquitin

28 July 2018

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HECTD2 is associated with susceptibility to mouse and human prion disease

28 July 2018

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Bortezomib arrests the proliferation of hepatocellular carcinoma cells HepG2 and JHH6 by differentially affecting E2F1, p21 and p27 levels.

28 July 2018

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Differential roles of the COOH termini of AAA subunits of PA700 (19 S regulator) in asymmetric assembly and activation of the 26 S proteasome

28 July 2018

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Prions and the proteasome

28 July 2018

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Mechanism of gate opening in the 20S proteasome by the proteasomal ATPases

28 July 2018

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A general model of prion strains and their pathogenicity

28 July 2018

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Docking of the proteasomal ATPases' carboxyl termini in the 20S proteasome's alpha ring opens the gate for substrate entry

28 July 2018

1 reference

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Abeta inhibits the proteasome and enhances amyloid and tau accumulation

28 July 2018

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Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide

28 July 2018

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Prions and their partners in crime

28 July 2018

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The roles of intracellular protein-degradation pathways in neurodegeneration

28 July 2018

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Good cop, bad cop: the different faces of NF-kappaB

28 July 2018

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ATP binding to PAN or the 26S ATPases causes association with the 20S proteasome, gate opening, and translocation of unfolded proteins.

28 July 2018

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The 1.9 A structure of a proteasome-11S activator complex and implications for proteasome-PAN/PA700 interactions.

28 July 2018

1 reference

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Proteasomes and their kin: proteases in the machine age

28 July 2018

1 reference

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Protein degradation and protection against misfolded or damaged proteins

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160194

Proteasome disassembly and downregulation is correlated with viability during stationary phase

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160194

Molecular distinction between pathogenic and infectious properties of the prion protein

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160194

Protofibrils, pores, fibrils, and neurodegeneration: separating the responsible protein aggregates from the innocent bystanders

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160194

The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160194

The axial channel of the proteasome core particle is gated by the Rpt2 ATPase and controls both substrate entry and product release

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160194

Structural basis for the activation of 20S proteasomes by 11S regulators

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160194

A gated channel into the proteasome core particle

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160194

28 July 2018

1 reference

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p53, the cellular gatekeeper for growth and division

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160194

Mice devoid of PrP are resistant to scrapie

28 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160194

p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160194

Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160194

Stimulation-dependent I kappa B alpha phosphorylation marks the NF-kappa B inhibitor for degradation via the ubiquitin-proteasome pathway

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160194

Novel proteinaceous infectious particles cause scrapie

28 July 2018

1 reference

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Acute polyglutamine expression in inducible mouse model unravels ubiquitin/proteasome system impairment and permanent recovery attributable to aggregate formation.

28 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160194

Interactions of PAN's C-termini with archaeal 20S proteasome and implications for the eukaryotic proteasome–ATPase interactions

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160194

Isolation of mammalian 26S proteasomes and p97/VCP complexes using the ubiquitin-like domain from HHR23B reveals novel proteasome-associated proteins

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160194

Polyubiquitin substrates allosterically activate their own degradation by the 26S proteasome.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160194

Depletion of 26S proteasomes in mouse brain neurons causes neurodegeneration and Lewy-like inclusions resembling human pale bodies.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160194

Disease-associated prion protein oligomers inhibit the 26S proteasome

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160194

Molecular basis of cerebral neurodegeneration in prion diseases.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160194

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160194

Prion protein is ubiquitinated after developing protease resistance in the brains of scrapie-infected mice

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160194

Formation of critical oligomers is a key event during conformational transition of recombinant syrian hamster prion protein

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160194

A transgenic mouse model of the ubiquitin/proteasome system

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160194

Binding of hydrophobic peptides to several non-catalytic sites promotes peptide hydrolysis by all active sites of 20 S proteasomes. Evidence for peptide-induced channel opening in the alpha-rings

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160194

Pathway complexity of prion protein assembly into amyloid

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160194

Post-natal knockout of prion protein alters hippocampal CA1 properties, but does not result in neurodegeneration

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160194

Proteasome inhibitors: from research tools to drug candidates

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160194

Reversible conversion of monomeric human prion protein between native and fibrilogenic conformations.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160194

The ubiquitin-proteasome pathway is required for processing the NF-kappa B1 precursor protein and the activation of NF-kappa B

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160194

The ubiquitin-proteasome proteolytic pathway

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160194

Species-barrier-independent prion replication in apparently resistant species

27 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038/EMBOJ.2011.224

Multiple folding pathways for heterologously expressed human prion protein

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038/EMBOJ.2011.224

Binding of amyloid beta protein to the 20 S proteasome

21 January 2018

1 reference

12 December 2020

Amyloid β-Protein Inhibits Ubiquitin-dependent Protein Degradation in Vitro

1 reference

12 December 2020

The sizes of peptides generated from protein by mammalian 26 and 20 S proteasomes. Implications for understanding the degradative mechanism and antigen presentation

1 reference

12 December 2020

Importance of the different proteolytic sites of the proteasome and the efficacy of inhibitors varies with the protein substrate

1 reference

12 December 2020

Formation of soluble oligomers and amyloid fibrils with physical properties of the scrapie isoform of the prion protein from the C-terminal domain of recombinant murine prion protein mPrP-(121-231)

1 reference

12 December 2020

Oligomerization of the human prion protein proceeds via a molten globule intermediate

1 reference

12 December 2020

Identifiers

DOI

10.1038/EMBOJ.2011.224

1 reference

6 August 2017

1 reference

6 August 2017

1 reference