Recombinant factor VIIa analog NN1731 (V158D/E296V/M298Q-FVIIa) enhances fibrin formation, structure and stability in lipidated hemophilic plasma (Q35167279)

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scientific article published on May 10, 2011

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English	Recombinant factor VIIa analog NN1731 (V158D/E296V/M298Q-FVIIa) enhances fibrin formation, structure and stability in lipidated hemophilic plasma	scientific article published on May 10, 2011

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scholarly article

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Europe PubMed Central

PubMed publication ID

6 August 2017

Recombinant factor VIIa analog NN1731 (V158D/E296V/M298Q-FVIIa) enhances fibrin formation, structure and stability in lipidated hemophilic plasma (English)

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Europe PubMed Central

PubMed publication ID

6 August 2017

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Kellie R. Machlus

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Kellie R. Machlus

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:21561645

1 December 2024

Alisa S. Wolberg

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Alisa S. Wolberg

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Europe PubMed Central

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1 December 2024

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Gary Koch

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6 August 2017

Mirella Ezban

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6 August 2017

Ulla Hedner

8

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Europe PubMed Central

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6 August 2017

Laura D. Gray

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:21561645

1 December 2024

Michael A. Hussey

2

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Europe PubMed Central

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Brittany M. Larson

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1 December 2024

Robert A. Campbell

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1 December 2024

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1 December 2024

publication date

10 May 2011

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6 August 2017

full work available at URL

https://cdr.lib.unc.edu/downloads/9g54xs143

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Europe PubMed Central

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1 December 2024

https://europepmc.org/articles/PMC3156970

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Europe PubMed Central

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1 December 2024

https://europepmc.org/articles/PMC3156970?pdf=render

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Europe PubMed Central

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:21561645

1 December 2024

https://doi.org/10.1016/j.thromres.2011.04.009

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:21561645

1 December 2024

https://api.elsevier.com/content/article/PII:S0049384811001721?httpAccept=text/xml

1 reference

10.1016/J.THROMRES.2011.04.009

https://api.crossref.org/works/10.1016/J.THROMRES.2011.04.009

1 December 2024

https://api.elsevier.com/content/article/PII:S0049384811001721?httpAccept=text/plain

1 reference

10.1016/J.THROMRES.2011.04.009

https://api.crossref.org/works/10.1016/J.THROMRES.2011.04.009

1 December 2024

Thrombosis Research

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

128

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

6

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

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describes a project that uses

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Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3156970/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

Intravascular inhibition of factor VIIa and the analogue NN1731 by antithrombin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156970

13 July 2018

Cellular procoagulant activity dictates clot structure and stability as a function of distance from the cell surface

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156970

13 July 2018

Enhancement of factor VIIa haemostatic efficacy by formulation with PEGylated liposomes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156970

13 July 2018

Recombinant factor VIIa: its background, development and clinical use.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156970

13 July 2018

Thrombin generation and fibrin clot structure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156970

13 July 2018

Activity and regulation of factor VIIa analogs with increased potency at the endothelial cell surface

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156970

13 July 2018

The alphaC domains of fibrinogen affect the structure of the fibrin clot, its physical properties, and its susceptibility to fibrinolysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156970

13 July 2018

Dosing with recombinant factor viia based on current evidence

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156970

13 July 2018

A new approach to treatment of bleeding episodes in young hemophilia patients: a single bolus megadose of recombinant activated factor VII (NovoSeven).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156970

13 July 2018

Rational design of coagulation factor VIIa variants with substantially increased intrinsic activity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156970

13 July 2018

Manipulation of the membrane binding site of vitamin K-dependent proteins: Enhanced biological function of human factor VII

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156970

13 July 2018

Platelet activity of high-dose factor VIIa is independent of tissue factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156970

13 July 2018

Native fibrin gel networks observed by 3D microscopy, permeation and turbidity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156970

13 July 2018

Mechanism by which recombinant factor VIIa shortens the aPTT: activation of factor X in the absence of tissue factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156970

13 July 2018

Production of large unilamellar vesicles by a rapid extrusion procedure: characterization of size distribution, trapped volume and ability to maintain a membrane potential

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156970

27 September 2018

Effects of tissue factor, thrombomodulin and elevated clotting factor levels on thrombin generation in the calibrated automated thrombogram.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156970

27 September 2018

Faster onset of effect and greater efficacy of NN1731 compared with rFVIIa, aPCC and FVIII in tail bleeding in hemophilic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156970

27 September 2018

Evaluation of the safety and pharmacokinetics of a fast-acting recombinant FVIIa analogue, NN1731, in healthy male subjects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156970

27 September 2018

Factor VIIa and its potential therapeutic use in bleeding-associated pathologies.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156970

27 September 2018

Effects of factor VIII inhibitor bypassing activity (FEIBA), recombinant factor VIIa or both on thrombin generation in normal and haemophilia A plasma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156970

27 September 2018

Effect of recombinant factor VIIa variant (NN1731) on platelet function, clot structure and force onset time in whole blood from healthy volunteers and haemophilia patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156970

27 September 2018

A novel approach to improving recombinant factor VIIa activity with a preserved platelet preparation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156970

27 September 2018

Haemophilia patients exhibit prolonged coagulation time but normal lag time of thrombin generation test: are these results really discordant?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156970

27 September 2018

Factor VIIa analogue (V158D/E296V/M298Q-FVIIa) normalises clot formation in whole blood from patients with severe haemophilia A.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156970

27 September 2018

A variant of recombinant factor VIIa with enhanced procoagulant and antifibrinolytic activities in an in vitro model of hemophilia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156970

27 September 2018

Prerequisites for recombinant factor VIIa-induced thrombin generation in plasmas deficient in factors VIII, IX or XI.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156970

27 September 2018

High dose factor VIIa improves clot structure and stability in a model of haemophilia B.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156970

27 September 2018

Augmented intrinsic activity of Factor VIIa by replacement of residues 305, 314, 337 and 374: evidence of two unique mutational mechanisms of activity enhancement

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156970

27 September 2018

Enhanced in vitro procoagulant and antifibrinolytic potential of superactive variants of recombinant factor VIIa in severe hemophilia A.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156970

27 September 2018

The role of recombinant factor VIIa (FVIIa) in fibrin structure in the absence of FVIII/FIX.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156970

27 September 2018

Improved hemostasis with superactive analogs of factor VIIa in a mouse model of hemophilia A.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156970

27 September 2018

Factor VIII inhibitor-bypassing agents act by inducing thrombin generation and can be monitored by a thrombin generation assay

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156970

27 September 2018

Influence of factor VIIa and phospholipids on coagulation in "acquired" hemophilia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156970

27 September 2018

Rationale for the use of high dose rFVIIa in a high-titre inhibitor patient with haemophilia B during major orthopaedic procedures

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156970

27 September 2018

The haemostatic plug in haemophilia A: a morphological study of haemostatic plug formation in bleeding time skin wounds of patients with severe haemophilia A.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156970

27 September 2018

A possible mechanism of action of activated factor VII independent of tissue factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/21561645

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prolonged in-vivo half-life of factor VIIa by fusion to albumin

1 reference

https://pubmed.ncbi.nlm.nih.gov/21561645

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fibrin gel structure obtained with a FVIIa analogue with enhanced FX-activating potential in haemophilia

1 reference

https://pubmed.ncbi.nlm.nih.gov/21561645

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activated protein C cleaves factor Va more efficiently on endothelium than on platelet surfaces

1 reference

https://pubmed.ncbi.nlm.nih.gov/21561645

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Changes in membrane phospholipid distribution during platelet activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/21561645

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.THROMRES.2011.04.009

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

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