Nuclear receptors as therapeutic targets for Alzheimer's disease (Q35165186)

6 August 2017

1 reference

title

Nuclear receptors as therapeutic targets for Alzheimer's disease (English)

1 reference

6 August 2017

0 references

Shweta Mandrekar-Colucci

series ordinal

1

1 reference

6 August 2017

Gary E. Landreth

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:21718217

5 December 2024

language of work or name

English

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publication date

1 July 2011

1 reference

full work available at URL

6 August 2017

https://europepmc.org/articles/pmc3156324?pdf=render

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:21718217

http://www.informapharmascience.com/doi/abs/10.1517/14728222.2011.863043

5 December 2024

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:21718217

https://europepmc.org/articles/PMC3156324

5 December 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:21718217

https://europepmc.org/articles/PMC3156324?pdf=render

5 December 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:21718217

https://doi.org/10.1517/14728222.2011.863043

5 December 2024

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:21718217

http://www.tandfonline.com/doi/pdf/10.1517/14728222.2011.863043

5 December 2024

1 reference

10.1517/14728222.2011.863043

Crossref

DOI

https://api.crossref.org/works/10.1517/14728222.2011.863043

Expert Opinion on Therapeutic Targets

5 December 2024

published in

1 reference

6 August 2017

volume

15

1 reference

6 August 2017

issue

9

1 reference

6 August 2017

page(s)

1085-1097

1 reference

Decreased clearance of CNS beta-amyloid in Alzheimer's disease

6 August 2017

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ATP-binding cassette transporter A1 mediates the beneficial effects of the liver X receptor agonist GW3965 on object recognition memory and amyloid burden in amyloid precursor protein/presenilin 1 mice

28 July 2018

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Rosiglitazone Monotherapy in Mild-to-Moderate Alzheimer’s Disease: Results from a Randomized, Double-Blind, Placebo-Controlled Phase III Study

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28 July 2018

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28 July 2018

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Microglia and inflammation in Alzheimer's disease

28 July 2018

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Inflammation, microglia, and Alzheimer's disease

28 July 2018

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CD14 and toll-like receptors 2 and 4 are required for fibrillar A{beta}-stimulated microglial activation.

28 July 2018

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28 July 2018

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Retinoic acid attenuates beta-amyloid deposition and rescues memory deficits in an Alzheimer's disease transgenic mouse model.

28 July 2018

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Mechanisms of microglia accumulation in Alzheimer's disease: therapeutic implications

28 July 2018

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Coordination of inflammation and metabolism by PPAR and LXR nuclear receptors

28 July 2018

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The RXR agonists PA024 and HX630 have different abilities to activate LXR/RXR and to induce ABCA1 expression in macrophage cell lines

28 July 2018

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PPARgamma agonists as therapeutics for the treatment of Alzheimer's disease

28 July 2018

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Alternative M2 activation of Kupffer cells by PPARdelta ameliorates obesity-induced insulin resistance.

28 July 2018

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28 July 2018

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Protective effects of NSAIDs on the development of Alzheimer disease

28 July 2018

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Dynamics of the microglial/amyloid interaction indicate a role in plaque maintenance

28 July 2018

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Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease.

28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance

28 July 2018

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28 July 2018

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A Oligomer-Induced Aberrations in Synapse Composition, Shape, and Density Provide a Molecular Basis for Loss of Connectivity in Alzheimer's Disease

28 July 2018

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Degradation of fibrillar forms of Alzheimer's amyloid beta-peptide by macrophages

28 July 2018

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28 July 2018

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28 July 2018

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Transcriptional regulation of metabolism

28 July 2018

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PPAR delta: a dagger in the heart of the metabolic syndrome

28 July 2018

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Efficacy of rosiglitazone in a genetically defined population with mild-to-moderate Alzheimer's disease

28 July 2018

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A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-gamma

28 July 2018

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Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo

28 July 2018

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Inactivation of liver X receptor beta leads to adult-onset motor neuron degeneration in male mice

28 July 2018

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Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective

28 July 2018

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28 July 2018

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The liver X receptor ligand T0901317 decreases amyloid beta production in vitro and in a mouse model of Alzheimer's disease

28 July 2018

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28 July 2018

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Retinoic Acid Receptor-Mediated Induction of ABCA1 in Macrophages

28 July 2018

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A cell surface receptor complex for fibrillar beta-amyloid mediates microglial activation.

28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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Peroxisome proliferator-activated receptor gamma-dependent repression of the inducible nitric oxide synthase gene

28 July 2018

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28 July 2018

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Apolipoprotein E is essential for amyloid deposition in the APP(V717F) transgenic mouse model of Alzheimer's disease

28 July 2018

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Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse

28 July 2018

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Association of microglia with amyloid plaques in brains of APP23 transgenic mice

28 July 2018

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28 July 2018

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Slow degradation of aggregates of the Alzheimer's disease amyloid beta-protein by microglial cells.

28 July 2018

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Binding of type II nuclear receptors and estrogen receptor to full and half-site estrogen response elements in vitro

28 July 2018

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Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors alpha and delta

28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma)

28 July 2018

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9-cis retinoic acid is a high affinity ligand for the retinoid X receptor

28 July 2018

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Critical role of astroglial apolipoprotein E and liver X receptor-α expression for microglial Aβ phagocytosis.

28 July 2018

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CC Chemokine Receptor 2 Deficiency Aggravates Cognitive Impairments and Amyloid Pathology in a Transgenic Mouse Model of Alzheimer's Disease

27 September 2018

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Retinoid X receptor gamma signaling accelerates CNS remyelination

27 September 2018

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Identification of a naturally occurring rexinoid, honokiol, that activates the retinoid X receptor

27 September 2018

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Control of macrophage activation and function by PPARs

27 September 2018

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Retinoid X receptor alpha controls innate inflammatory responses through the up-regulation of chemokine expression.

27 September 2018

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2010 Alzheimer's disease facts and figures

27 September 2018

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Efficacy of PPAR-γ agonist pioglitazone in mild Alzheimer disease

27 September 2018

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A PPARdelta agonist reduces amyloid burden and brain inflammation in a transgenic mouse model of Alzheimer's disease

27 September 2018

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PPAR-delta senses and orchestrates clearance of apoptotic cells to promote tolerance

27 September 2018

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Liver X receptor activation restores memory in aged AD mice without reducing amyloid

27 September 2018

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Activation of Wnt signaling by lithium and rosiglitazone reduced spatial memory impairment and neurodegeneration in brains of an APPswe/PSEN1DeltaE9 mouse model of Alzheimer's disease.

27 September 2018

1 reference

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Macrophage-mediated degradation of beta-amyloid via an apolipoprotein E isoform-dependent mechanism.

27 September 2018

1 reference

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Pioglitazone improved cognition in a pilot study on patients with Alzheimer's disease and mild cognitive impairment with diabetes mellitus

27 September 2018

1 reference

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Powerful beneficial effects of macrophage colony-stimulating factor on beta-amyloid deposition and cognitive impairment in Alzheimer's disease

27 September 2018

1 reference

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Alternative activation of macrophages: an immunologic functional perspective

27 September 2018

1 reference

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Complete rescue of cerebrovascular function in aged Alzheimer's disease transgenic mice by antioxidants and pioglitazone, a peroxisome proliferator-activated receptor gamma agonist

27 September 2018

1 reference

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ApoE promotes the proteolytic degradation of Abeta

27 September 2018

1 reference

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Arginase I induction by modified lipoproteins in macrophages: a peroxisome proliferator-activated receptor-gamma/delta-mediated effect that links lipid metabolism and immunity

27 September 2018

1 reference

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Interleukin-4 mediates the neuroprotective effects of rosiglitazone in the aged brain.

27 September 2018

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Deletion of tumor necrosis factor death receptor inhibits amyloid beta generation and prevents learning and memory deficits in Alzheimer's mice

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156324

Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like disease

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156324

The LXR agonist TO901317 selectively lowers hippocampal Abeta42 and improves memory in the Tg2576 mouse model of Alzheimer's disease

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156324

Normal hematopoiesis after conditional targeting of RXRalpha in murine hematopoietic stem/progenitor cells.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156324

The effects of ABCA1 on cholesterol efflux and Abeta levels in vitro and in vivo.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156324

Lack of ABCA1 considerably decreases brain ApoE level and increases amyloid deposition in APP23 mice

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156324

Deletion of Abca1 increases Abeta deposition in the PDAPP transgenic mouse model of Alzheimer disease

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156324

The absence of ABCA1 decreases soluble ApoE levels but does not diminish amyloid deposition in two murine models of Alzheimer disease.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156324

Microglial phagocytosis induced by fibrillar beta-amyloid and IgGs are differentially regulated by proinflammatory cytokines.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156324

Acute treatment with the PPARgamma agonist pioglitazone and ibuprofen reduces glial inflammation and Abeta1-42 levels in APPV717I transgenic mice

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156324

Insulin resistance contributes to aberrant stress responses in the Tg2576 mouse model of Alzheimer's disease

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156324

Anti-inflammatory drug therapy alters beta-amyloid processing and deposition in an animal model of Alzheimer's disease.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156324

ABCA1 modulates CSF cholesterol levels and influences the age at onset of Alzheimer's disease

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156324

Human and murine ApoE markedly alters A beta metabolism before and after plaque formation in a mouse model of Alzheimer's disease

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156324

Anti-inflammatory actions of peroxisome proliferator-activated receptor gamma agonists in Alzheimer's disease

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156324

A selective peroxisome proliferator-activated receptor delta agonist promotes reverse cholesterol transport

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156324

Peroxisome proliferator-activated receptor gamma ligands suppress the transcriptional activation of cyclooxygenase-2. Evidence for involvement of activator protein-1 and CREB-binding protein/p300.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156324

Uptake, degradation, and release of fibrillar and soluble forms of Alzheimer's amyloid beta-peptide by microglial cells.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156324

Occurrence of the diffuse amyloid beta-protein (Abeta) deposits with numerous Abeta-containing glial cells in the cerebral cortex of patients with Alzheimer's disease

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156324

Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156324

Differential expression and activation of a family of murine peroxisome proliferator-activated receptors

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156324

Role of the beta-amyloid protein in Alzheimer's disease.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3156324

Knock-out and transgenic mouse models of tauopathies.

27 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1517/14728222.2011.863043

Purification of apolipoprotein E attenuates isoform-specific binding to beta-amyloid

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21718217

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Chemokine monocyte chemoattractant protein-1 is expressed by astrocytes after mechanical injury to the brain

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21718217

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Journal of Clinical Investigation

52

118

671

Wahrle SE

2008

1 reference

10.1517/14728222.2011.863043

Crossref

DOI

https://api.crossref.org/works/10.1517/14728222.2011.863043

10.1517/14728222.2011.863043

5 December 2024

Identifiers

DOI

1 reference

release_e3la36hdvndf7lzsx6qykhckde

6 August 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/e3la36hdvndf7lzsx6qykhckde

mapped directly with Wikidata item

24 November 2022

based on heuristic

PMC publication ID

3156324

1 reference

6 August 2017

1 reference