Is timing everything? Therapeutic potential of modulators of cardiac Na( ) transporters (Q35164744)

6 August 2017

1 reference

title

Is timing everything? Therapeutic potential of modulators of cardiac Na( ) transporters (English)

1 reference

6 August 2017

Sheila A Doggrell

1

1 reference

6 August 2017

Jules C Hancox

series ordinal

2

1 reference

6 August 2017

language of work or name

English

0 references

publication date

1 July 2003

1 reference

Expert Opinion on Investigational Drugs

6 August 2017

published in

1 reference

6 August 2017

volume

12

1 reference

6 August 2017

issue

7

1 reference

6 August 2017

page(s)

1123-1142

1 reference

Sodium-calcium exchange: a molecular perspective

6 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1517/13543784.12.7.1123

The myocardial Na /H exchanger: a potential therapeutic target for the prevention of myocardial ischaemic and reperfusion injury and attenuation of postinfarction heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.12.7.1123

Molecular cloning and characterization of a novel (Na ,K )/H exchanger localized to the trans-Golgi network

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.12.7.1123

Regulation of cardiac sarcolemmal Na /H exchanger activity by endogenous ligands. Relevance to ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.12.7.1123

Differential effects of angiotensin AT1 and AT2 receptors on the expression, translation and function of the Na -H exchanger and Na -HCO3- symporter in the rat heart after myocardial infarction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.12.7.1123

Upregulation of myocardial Na /H exchanger induced by chronic treatment with a selective inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.12.7.1123

Protective effects of HOE642, a selective sodium-hydrogen exchange subtype 1 inhibitor, on cardiac ischaemia and reperfusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.12.7.1123

Hoe 694, a new Na /H exchange inhibitor and its effects in cardiac ischaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.12.7.1123

Preischaemic as well as postischaemic application of a Na /H exchange inhibitor reduces infarct size in pigs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.12.7.1123

A rapid ischemia-induced apoptosis in isolated rat hearts and its attenuation by the sodium-hydrogen exchange inhibitor HOE 642 (cariporide).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.12.7.1123

Dose-dependent reduction of myocardial infarct mass in rabbits by the NHE-1 inhibitor cariporide (HOE 642).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.12.7.1123

Protection from AMP 579 can be added to that from either cariporide or ischemic preconditioning in ischemic rabbit heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.12.7.1123

Na( )/H( )-exchange inhibition and aprotinin administration: promising tools for myocardial protection during minimally invasive CABG.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.12.7.1123

Discovery of zoniporide: a potent and selective sodium-hydrogen exchanger type 1 (NHE-1) inhibitor with high aqueous solubility

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.12.7.1123

Zoniporide: a potent and highly selective inhibitor of human Na( )/H( ) exchanger-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.12.7.1123

Preischemic and postischemic treatment with a new Na /H -exchange inhibitor, FR183998, shows cardioprotective effects in rats with cardiac ischemia and reperfusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.12.7.1123

Na( )-H exchange inhibition protects against mechanical, ultrastructural, and biochemical impairment induced by low concentrations of lysophosphatidylcholine in isolated rat hearts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.12.7.1123

Regulation of sarcolemmal Na( )/H( ) exchange by hydrogen peroxide in adult rat ventricular myocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.12.7.1123

The Na( )/H( ) exchange inhibitor eniporide as an adjunct to early reperfusion therapy for acute myocardial infarction. Results of the evaluation of the safety and cardioprotective effects of eniporide in acute myocardial infarction (ESCAMI) trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.12.7.1123

Na( )/H( ) exchange inhibitors for cardioprotective therapy: progress, problems and prospects

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.12.7.1123

Effects and interaction, of cariporide and preconditioning on cardiac arrhythmias and infarction in rat in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.12.7.1123

Mitochondrial ATP-sensitive K channels play a role in cardioprotection by Na -H exchange inhibition against ischemia/reperfusion injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.12.7.1123

Successful ventricular defibrillation by the selective sodium-hydrogen exchanger isoform-1 inhibitor cariporide

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.12.7.1123

Effects of moderate hypothermia on sarcolemmal Na( )/H( ) exchanger activity and its inhibition by cariporide in cardiac ventricular myocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.12.7.1123

Sodium/hydrogen-exchanger inhibition during cardioplegic arrest and cardiopulmonary bypass: an experimental study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.12.7.1123

Na /H exchange inhibition improves post-transplant myocardial compliance in 4-hour stored donor hearts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.12.7.1123

Effects of cariporide and losartan on hypertrophy, calcium transients, contractility, and gene expression in congestive heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.12.7.1123

Contributions of endothelin-1 and sodium hydrogen exchanger-1 in the diabetic myocardium.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.12.7.1123

Inhibition of the cardiac electrogenic sodium bicarbonate cotransporter reduces ischemic injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.12.7.1123

Identification of sodium-calcium exchange current in single ventricular cells of guinea-pig

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.12.7.1123

Stoichiometry of Na -Ca2 exchange in inside-out patches excised from guinea-pig ventricular myocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.12.7.1123

A new topological model of the cardiac sarcolemmal Na -Ca2 exchanger

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.12.7.1123

Cardiac Na( )-Ca(2 ) exchange: molecular and pharmacological aspects

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.12.7.1123

Chimeric analysis of Na( )/Ca(2 ) exchangers NCX1 and NCX3 reveals structural domains important for differential sensitivity to external Ni(2 ) or Li( ).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.12.7.1123

Integrative analysis of calcium signalling in cardiac muscle.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.12.7.1123

Relation between reverse sodium-calcium exchange and sarcoplasmic reticulum calcium release in guinea pig ventricular cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.12.7.1123

Contribution of reverse-mode sodium–calcium exchange to contractions in failing human left ventricular myocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.12.7.1123

Na -Ca2 exchange activity is localized in the T-tubules of rat ventricular myocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.12.7.1123

The role of Na-Ca exchange current in the cardiac action potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.12.7.1123

Sinoatrial nodal cell ryanodine receptor and Na( )-Ca(2 ) exchanger: molecular partners in pacemaker regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.12.7.1123

Sarcoplasmic reticulum Ca2 release is not a dominating factor in sinoatrial node pacemaker activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.12.7.1123

Cyclic variation of intracellular calcium: a critical factor for cardiac pacemaker cell dominance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.12.7.1123

Anti-adrenergic effect of adenosine on Na( )-Ca(2 ) exchange current recorded from guinea-pig ventricular myocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.12.7.1123

Phenylephrine-induced stimulation of Na /Ca2 exchange in rat ventricular myocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.12.7.1123

Regulation by endothelin-1 of Na -Ca2 exchange current (I(NaCa)) from guinea-pig isolated ventricular myocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.12.7.1123

Autocrine stimulation of cardiac Na( )-Ca(2 ) exchanger currents by endogenous endothelin released by angiotensin II.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.12.7.1123

Evidence for a modulatory effect of external potassium ions on ionic current mediated by the cardiac Na -Ca2 exchanger

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.12.7.1123

Role of Intracellular Sodium Overload in the Genesis of Cardiac Arrhythmias

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.12.7.1123

Na -Ca2 exchanger remodeling in pressure overload cardiac hypertrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.12.7.1123

Sodium channel blockade reduces hypoxic sodium loading and sodium-dependent calcium loading

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.12.7.1123

Reperfusion arrhythmias: new insights into the role of the Na( )/Ca(2 ) exchanger

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.12.7.1123

Reperfusion-induced Ins(1,4,5)P(3) generation and arrhythmogenesis require activation of the Na( )/Ca(2 ) exchanger

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.12.7.1123

Hydroxyl radical-induced acute diastolic dysfunction is due to calcium overload via reverse-mode Na( )-Ca(2 ) exchange

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.12.7.1123

Functional expression of the human cardiac Na /Ca2 exchanger in Sf9 cells: rapid and specific Ni2 transport.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.12.7.1123

Inhibition of Na /Ca2 exchange in membrane vesicle and papillary muscle preparations from guinea pig heart by analogs of amiloride

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.12.7.1123

Clinical potential of sodium-calcium exchanger inhibitors as antiarrhythmic agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.12.7.1123

Inhibitory effect of aprindine on Na /Ca2 exchange current in guinea-pig cardiac ventricular myocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.12.7.1123

Mode-dependent inhibition by quinidine of Na -Ca2 exchanger current from guinea-pig isolated ventricular myocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.12.7.1123

Inhibitory effect of amiodarone on Na( )/Ca(2 ) exchange current in guinea-pig cardiac myocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.12.7.1123

The effect of exchanger inhibitory peptide (XIP) on sodium-calcium exchange current in guinea pig ventricular cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.12.7.1123

Positively charged cyclic hexapeptides, novel blockers for the cardiac sarcolemma Na( )-Ca2 exchanger.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.12.7.1123

Actions of myristyl-FRCRCFa, a cell-permeant blocker of the cardiac sarcolemmal Na-Ca exchanger, tested in rabbit ventricular myocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.12.7.1123

Role of the reverse mode of the Na /Ca2 exchanger in reoxygenation-induced cardiomyocyte injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.12.7.1123

Inhibition by KB-r7943 of the reverse mode of the Na /Ca2 exchanger reduces Ca2 overload in ischemic-reperfused rat hearts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.12.7.1123

Effects of a selective inhibitor of Na /Ca2 exchange, KB-R7943, on reoxygenation-induced injuries in guinea pig papillary muscles

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.12.7.1123

Very low dose of the Na( )/Ca(2 ) exchange inhibitor, KB-R7943, protects ischemic reperfused aged Fischer 344 rat hearts: considerable strain difference in the sensitivity to KB-R7943.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.12.7.1123

The novel Na( )/Ca(2 ) exchange inhibitor KB-R7943 also blocks native and expressed neuronal nicotinic receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.12.7.1123

Effect of SEA0400, a novel inhibitor of sodium-calcium exchanger, on myocardial ionic currents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.12.7.1123

Knockout mice for pharmacological screening: testing the specificity of Na -Ca2 exchange inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.12.7.1123

Protective effects of SEA0400, a novel and selective inhibitor of the Na /Ca2 exchanger, on myocardial ischemia-reperfusion injuries

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.12.7.1123

Arylcyclopropanecarboxyl guanidines as novel, potent, and selective inhibitors of the sodium hydrogen exchanger isoform-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.12.7.1123

Characterization of sabiporide, a new specific NHE-1 inhibitor exhibiting slow dissociation kinetics and cardioprotective effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.12.7.1123

Protection of the ischaemic myocardium by Na /H exchange inhibitors: potential mechanisms of action

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.12.7.1123

Effect of inhibition of Na( )/Ca(2 ) exchanger at the time of myocardial reperfusion on hypercontracture and cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/13543784.12.7.1123

10.1517/13543784.12.7.1123

21 January 2018

Identifiers

DOI

1 reference

6 August 2017

1 reference