HIF prolyl and asparaginyl hydroxylases in the biological response to intracellular O(2) levels (Q35164093)

6 August 2017

1 reference

title

HIF prolyl and asparaginyl hydroxylases in the biological response to intracellular O(2) levels (English)

1 reference

6 August 2017

Peter J Ratcliffe

2

0 references

author name string

Norma Masson

series ordinal

1

1 reference

6 August 2017

language of work or name

English

0 references

publication date

1 August 2003

1 reference

6 August 2017

published in

Journal of Cell Science

1 reference

6 August 2017

volume

116

1 reference

6 August 2017

issue

Pt 15

1 reference

6 August 2017

page(s)

3041-3049

1 reference

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

6 August 2017

cites work

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/citations/10.1038/20459

Prolyl 4-hydroxylases and their protein disulfide isomerase subunit

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1242/JCS.00655

Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1242/JCS.00655

Role of prolyl hydroxylation in oncogenically stabilized hypoxia-inducible factor-1alpha

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1242/JCS.00655

Efficient translation of mouse hypoxia-inducible factor-1alpha under normoxic and hypoxic conditions

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1242/JCS.00655

Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1242/JCS.00655

Novel estrogen and tamoxifen induced genes identified by SAGE (Serial Analysis of Gene Expression)

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1242/JCS.00655

Characterization and comparative analysis of the EGLN gene family

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1242/JCS.00655

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1242/JCS.00655

Structural basis for Hif-1 alpha /CBP recognition in the cellular hypoxic response

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1242/JCS.00655

A variant of nuclear localization signal of bipartite-type is required for the nuclear translocation of hypoxia inducible factors (1alpha, 2alpha and 3alpha)

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1242/JCS.00655

Cellular adaptation to hypoxia: O2-sensing protein hydroxylases, hypoxia-inducible transcription factors, and O2-regulated gene expression

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1242/JCS.00655

Sequence determinants in hypoxia-inducible factor-1alpha for hydroxylation by the prolyl hydroxylases PHD1, PHD2, and PHD3.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1242/JCS.00655

Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1242/JCS.00655

Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1242/JCS.00655

HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1242/JCS.00655

Histone deacetylases induce angiogenesis by negative regulation of tumor suppressor genes

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1242/JCS.00655

Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1 alpha

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1242/JCS.00655

Perspectives on oxygen sensing

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1242/JCS.00655

Carboxyl-terminal transactivation activity of hypoxia-inducible factor 1 alpha is governed by a von Hippel-Lindau protein-independent, hydroxylation-regulated association with p300/CBP.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1242/JCS.00655

Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1242/JCS.00655

Regulation of the hypoxia-inducible transcription factor 1alpha by the ubiquitin-proteasome pathway

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1242/JCS.00655

Activation of Hypoxia-inducible Factor-1; Definition of Regulatory Domains within the α Subunit

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1242/JCS.00655

HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1242/JCS.00655

Activation of the HIF pathway in cancer

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1242/JCS.00655

Post-transcriptional regulation of vascular endothelial growth factor mRNA by the product of the VHL tumor suppressor gene

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1242/JCS.00655

Control of the hypoxic response in Drosophila melanogaster by the basic helix-loop-helix PAS protein similar.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1242/JCS.00655

Structural and mechanistic studies on 2-oxoglutarate-dependent oxygenases and related enzymes

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1242/JCS.00655

Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1242/JCS.00655

Overexpression of PH-4, a novel putative proline 4-hydroxylase, modulates activity of hypoxia-inducible transcription factors

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1242/JCS.00655

Jab1 interacts directly with HIF-1alpha and regulates its stability

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1242/JCS.00655

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1242/JCS.00655

Activated pp60c-Src leads to elevated hypoxia-inducible factor (HIF)-1alpha expression under normoxia

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1242/JCS.00655

Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1242/JCS.00655

Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1242/JCS.00655

Induction of hypervascularity without leakage or inflammation in transgenic mice overexpressing hypoxia-inducible factor-1alpha

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1242/JCS.00655

Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1242/JCS.00655

Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1242/JCS.00655

Oxygen sensing and molecular adaptation to hypoxia

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1242/JCS.00655

Hypoxia: the tumor's gateway to progression along the angiogenic pathway

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1242/JCS.00655

Oxygen-dependent ubiquitination and degradation of hypoxia-inducible factor requires nuclear-cytoplasmic trafficking of the von Hippel-Lindau tumor suppressor protein

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1242/JCS.00655

The PAS superfamily: sensors of environmental and developmental signals

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1242/JCS.00655

FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1242/JCS.00655

Intracellular localisation of human HIF-1 alpha hydroxylases: implications for oxygen sensing

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1242/JCS.00655

Multiple splice variants of the human HIF-3 alpha locus are targets of the von Hippel-Lindau E3 ubiquitin ligase complex

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1242/JCS.00655

Hypoxia-inducible factor 1alpha protein expression is controlled by oxygen-regulated ubiquitination that is disrupted by deletions and missense mutations

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1242/JCS.00655

Inducible operation of the erythropoietin 3' enhancer in multiple cell lines: evidence for a widespread oxygen-sensing mechanism

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1242/JCS.00655

Induction of HIF-1alpha in response to hypoxia is instantaneous

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1242/JCS.00655

Angiogenesis is induced in a rabbit model of hindlimb ischemia by naked DNA encoding an HIF-1alpha/VP16 hybrid transcription factor

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1242/JCS.00655

Structure of factor-inhibiting hypoxia-inducible factor 1: An asparaginyl hydroxylase involved in the hypoxic response pathway

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1242/JCS.00655

Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1242/JCS.00655

Cobalt inhibits the interaction between hypoxia-inducible factor-alpha and von Hippel-Lindau protein by direct binding to hypoxia-inducible factor-alpha

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1242/JCS.00655

Insulin stimulates hypoxia-inducible factor 1 through a phosphatidylinositol 3-kinase/target of rapamycin-dependent signaling pathway

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1242/JCS.00655

Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1242/JCS.00655

Molecular basis of the VHL hereditary cancer syndrome

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1242/JCS.00655

Mammalian EGLN genes have distinct patterns of mRNA expression and regulation

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1242/JCS.00655

Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1242/JCS.00655

The transcriptional activation function of the HIF-like factor requires phosphorylation at a conserved threonine

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1242/JCS.00655

Peptide blockade of HIFalpha degradation modulates cellular metabolism and angiogenesis

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1242/JCS.00655

The iron(II) and 2-oxoacid-dependent dioxygenases and their role in metabolism

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1242/JCS.00655

Inhibitory PAS domain protein (IPAS) is a hypoxia-inducible splicing variant of the hypoxia-inducible factor-3alpha locus

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1242/JCS.00655

Oxygen-regulated and transactivating domains in endothelial PAS protein 1: comparison with hypoxia-inducible factor-1alpha.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1242/JCS.00655

HIF-1-dependent transcriptional activity is required for oxygen-mediated HIF-1alpha degradation

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1242/JCS.00655

HIF-1: mediator of physiological and pathophysiological responses to hypoxia

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1242/JCS.00655

Differential regulation of HIF-1 alpha prolyl-4-hydroxylase genes by hypoxia in human cardiovascular cells

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1242/JCS.00655

Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1242/JCS.00655

The contribution of VHL substrate binding and HIF1-alpha to the phenotype of VHL loss in renal cell carcinoma

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1242/JCS.00655

Falkor, a novel cell growth regulator isolated by a functional genetic screen

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1242/JCS.00655

A conserved family of prolyl-4-hydroxylases that modify HIF

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1242/JCS.00655

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1242/JCS.00655

von Hippel-Lindau protein binds hyperphosphorylated large subunit of RNA polymerase II through a proline hydroxylation motif and targets it for ubiquitination

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1242/JCS.00655

Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1242/JCS.00655

A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1242/JCS.00655

Transactivation and inhibitory domains of hypoxia-inducible factor 1alpha. Modulation of transcriptional activity by oxygen tension

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1242/JCS.00655

Software and database for the analysis of mutations in the VHL gene

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1242/JCS.00655

p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1alpha (HIF-1alpha) and enhance the transcriptional activity of HIF-1.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1242/JCS.00655

Regulation and destabilization of HIF-1alpha by ARD1-mediated acetylation

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1242/JCS.00655

Signal transduction in hypoxic cells: inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia-inducible factor-1alpha

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1242/JCS.00655

Structure of a cephalosporin synthase

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1242/JCS.00655

FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1242/JCS.00655

SM-20 is a novel mitochondrial protein that causes caspase-dependent cell death in nerve growth factor-dependent neurons

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1242/JCS.00655

Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1242/JCS.00655

Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1 alpha

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1242/JCS.00655

Hypoxia-inducible factor asparaginyl hydroxylase (FIH-1) catalyses hydroxylation at the beta-carbon of asparagine-803

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1242/JCS.00655

EPAS1 trans-activation during hypoxia requires p42/p44 MAPK

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1242/JCS.00655

Identifiers

DOI

10.1242/JCS.00655

1 reference

6 August 2017

1 reference