Deficient synthesis of glutathione underlies oxidative stress in aging and can be corrected by dietary cysteine and glycine supplementation (Q35163911)

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8 February 2020

title

Deficient synthesis of glutathione underlies oxidative stress in aging and can be corrected by dietary cysteine and glycine supplementation (English)

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8 February 2020

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4

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8 February 2020

author name string

Rajagopal V Sekhar

1

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8 February 2020

Sanjeet G Patel

2

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8 February 2020

Anuradha P Guthikonda

3

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8 February 2020

Ashok Balasubramanyam

5

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8 February 2020

George E Taffet

6

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8 February 2020

Farook Jahoor

7

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8 February 2020

language of work or name

English

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publication date

27 July 2011

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American Journal of Clinical Nutrition

8 February 2020

published in

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8 February 2020

volume

94

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8 February 2020

issue

3

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8 February 2020

page(s)

847-853

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Glutathione Synthesis Is Diminished in Patients With Uncontrolled Diabetes and Restored by Dietary Supplementation With Cysteine and Glycine

8 February 2020

cites work

1 reference

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Pro-oxidant shift in glutathione redox state during aging

13 July 2018

1 reference

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Markers of oxidative stress in erythrocytes during aging in humans

13 July 2018

1 reference

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In vivo rates of erythrocyte glutathione synthesis in adults with sickle cell disease.

13 July 2018

1 reference

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Glutathione metabolism during aging and in Alzheimer disease

13 July 2018

1 reference

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Synthesis of erythrocyte glutathione in healthy adults consuming the safe amount of dietary protein

13 July 2018

1 reference

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13 July 2018

1 reference

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Methods for measuring glutathione concentration and rate of synthesis

13 July 2018

1 reference

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Blood glutathione synthesis rates in healthy adults receiving a sulfur amino acid-free diet

13 July 2018

1 reference

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Glutathione in human plasma: decline in association with aging, age-related macular degeneration, and diabetes

13 July 2018

1 reference

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Lipid peroxidation, antioxidant protection and aging

13 July 2018

1 reference

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Increased protein requirements in elderly people: new data and retrospective reassessments

13 July 2018

1 reference

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Reversal of age-associated decline in immune responsiveness by dietary glutathione supplementation in mice

13 July 2018

1 reference

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Amino acids and proteins in relation to the nutrition of elderly people

13 July 2018

1 reference

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Low blood glutathione levels in healthy aging adults

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3155927

Cysteine and Glycine Supplementation Modulate the Metabolic Response to Tumor Necrosis Factor α in Rats Fed a Low Protein Diet

13 July 2018

1 reference

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Erythrocyte glutathione concentration and production during hyperinsulinemia, hyperglycemia, and endotoxemia in healthy humans

13 July 2018

1 reference

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Oxidant stress in healthy normal-weight, overweight, and obese individuals

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3155927

Effect of glutathione (GSH) depletion on DNA damage and blood chemistry in aged and young rats

27 September 2018

1 reference

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One-step solid-phase extraction procedure for F(2)-isoprostanes.

27 September 2018

1 reference

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Age-associated decline in gamma-glutamylcysteine synthetase gene expression in rats.

27 September 2018

1 reference

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Whole-body protein turnover in the healthy elderly

27 September 2018

1 reference

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27 September 2018

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12 December 2020

Protein-deficient pigs cannot maintain reduced glutathione homeostasis when subjected to the stress of inflammation

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12 December 2020

Effect of liver cirrhosis and age on the glutathione concentration in the plasma, erythrocytes, and gastric mucosa of man

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12 December 2020

Splanchnic and whole-body leucine kinetics in young and elderly men

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12 December 2020

Protein requirements and ageing: metabolic demand and efficiency of utilization

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12 December 2020

An impediment to glutathione diffusion in older normal human lenses: a possible precondition for nuclear cataract

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12 December 2020

Ferrous ion oxidation in presence of xylenol orange for detection of lipid hydroperoxides in plasma

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12 December 2020

Antioxidant systems in rat lens as a function of age: effect of chronic administration of vitamin E and ascorbate

1 reference

12 December 2020

Effects of nonsulfur and sulfur amino acids on the regulation of hepatic enzymes of cysteine metabolism

1 reference

12 December 2020

Effects of the association of aging and obesity on lipids, lipoproteins and oxidative stress biomarkers: A comparison of older with young men

1 reference

12 December 2020

In vivo rates of erythrocyte glutathione synthesis in children with severe protein-energy malnutrition

1 reference

12 December 2020

Changes in glutathione and glutathione metabolizing enzymes in erythrocytes and lymphocytes of mice as a function of age

1 reference

12 December 2020

Changes in glutathione and its metabolizing enzymes in human erythrocytes and lymphocytes with age

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12 December 2020

Glutathione and lipid peroxidation in the aging rat

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12 December 2020

Glutathione and lymphocyte activation: a function of ageing and auto-immune disease

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12 December 2020

Lipid peroxidation and antioxidant enzymatic systems in rat retina as a function of age

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12 December 2020

Identifiers

DOI

10.3945/AJCN.110.003483

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21795440 AND SRC:MED&resulttype=core&format=json

8 February 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21795440 AND SRC:MED&resulttype=core&format=json

8 February 2020

PubMed publication ID

21795440

1 reference