The DNA repair endonuclease XPG interacts directly and functionally with the WRN helicase defective in Werner syndrome (Q35159006)

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31 January 2020

title

The DNA repair endonuclease XPG interacts directly and functionally with the WRN helicase defective in Werner syndrome (English)

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31 January 2020

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5

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31 January 2020

John A. Tainer

9

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31 January 2020

Sophia B Chernikova

2

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Judith Campisi

10

object named as

Judith Campisi

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31 January 2020

author name string

Kelly S Trego

1

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31 January 2020

Albert R Davalos

3

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31 January 2020

J Jefferson P Perry

4

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31 January 2020

Cliff Ng

6

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Miaw-Sheue Tsai

7

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Steven M Yannone

8

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31 January 2020

Priscilla K Cooper

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publication date

15 June 2011

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31 January 2020

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31 January 2020

volume

10

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31 January 2020

issue

12

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31 January 2020

page(s)

1998-2007

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Human Flap Endonuclease Structures, DNA Double-Base Flipping, and a Unified Understanding of the FEN1 Superfamily

31 January 2020

cites work

1 reference

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Molecular cooperation between the Werner syndrome protein and replication protein A in relation to replication fork blockage

13 July 2018

1 reference

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Hyper telomere recombination accelerates replicative senescence and may promote premature aging

13 July 2018

1 reference

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Depletion of Werner helicase results in mitotic hyperrecombination and pleiotropic homologous and nonhomologous recombination phenotypes

13 July 2018

1 reference

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Identification of a coiled coil in werner syndrome protein that facilitates multimerization and promotes exonuclease processivity

13 July 2018

1 reference

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Structural basis for DNA strand separation by the unconventional winged-helix domain of RecQ helicase WRN

13 July 2018

1 reference

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Coordination of dual incision and repair synthesis in human nucleotide excision repair

13 July 2018

1 reference

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XPG: its products and biological roles

13 July 2018

1 reference

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Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining

13 July 2018

1 reference

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Intrinsic ssDNA annealing activity in the C-terminal region of WRN.

13 July 2018

1 reference

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Transcription-coupled nucleotide excision repair in mammalian cells: molecular mechanisms and biological effects

13 July 2018

1 reference

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Sequential recruitment of the repair factors during NER: the role of XPG in initiating the resynthesis step.

13 July 2018

1 reference

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Replication fork regression in vitro by the Werner syndrome protein (WRN): holliday junction formation, the effect of leading arm structure and a potential role for WRN exonuclease activity.

13 July 2018

1 reference

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The human Werner syndrome protein stimulates repair of oxidative DNA base damage by the DNA glycosylase NEIL1

13 July 2018

1 reference

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XPG stabilizes TFIIH, allowing transactivation of nuclear receptors: implications for Cockayne syndrome in XP-G/CS patients

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154418

Domain swapping between FEN-1 and XPG defines regions in XPG that mediate nucleotide excision repair activity and substrate specificity.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154418

Crystal structure of the HRDC domain of human Werner syndrome protein, WRN

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154418

The Werner and Bloom syndrome proteins catalyze regression of a model replication fork

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154418

WRN exonuclease structure and molecular mechanism imply an editing role in DNA end processing

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154418

Recognition of RNA polymerase II and transcription bubbles by XPG, CSB, and TFIIH: insights for transcription-coupled repair and Cockayne Syndrome

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154418

Nuclear matrix support of DNA replication

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154418

Accumulation of Werner protein at DNA double-strand breaks in human cells

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154418

POT1 stimulates RecQ helicases WRN and BLM to unwind telomeric DNA substrates

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154418

RecQ family members combine strand pairing and unwinding activities to catalyze strand exchange

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154418

Severe growth retardation and short life span of double-mutant mice lacking Xpa and exon 15 of Xpg.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154418

Defective telomere lagging strand synthesis in cells lacking WRN helicase activity.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154418

Identification of the XPG region that causes the onset of Cockayne syndrome by using Xpg mutant mice generated by the cDNA-mediated knock-in method

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154418

Deficiency in the nuclease activity of xeroderma pigmentosum G in mice leads to hypersensitivity to UV irradiation

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154418

Bloom syndrome cells undergo p53-dependent apoptosis and delayed assembly of BRCA1 and NBS1 repair complexes at stalled replication forks

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154418

The Werner syndrome protein stimulates DNA polymerase beta strand displacement synthesis via its helicase activity

13 July 2018

1 reference

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Structural determinants for substrate binding and catalysis by the structure-specific endonuclease XPG

13 July 2018

1 reference

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Homologous recombination resolution defect in werner syndrome

13 July 2018

1 reference

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Telomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicases

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154418

Relationship of neurologic degeneration to genotype in three xeroderma pigmentosum group G patients.

13 July 2018

1 reference

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Reversible manipulation of telomerase expression and telomere length. Implications for the ionizing radiation response and replicative senescence of human cells

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154418

Translocation of Cockayne syndrome group A protein to the nuclear matrix: possible relevance to transcription-coupled DNA repair

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154418

Xeroderma pigmentosum/cockayne syndrome complex: first neuropathological study and review of eight other cases

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154418

Factors influencing the removal of thymine glycol from DNA in gamma-irradiated human cells

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154418

Werner syndrome protein is regulated and phosphorylated by DNA-dependent protein kinase

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154418

The Bloom's and Werner's syndrome proteins are DNA structure-specific helicases

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154418

Werner helicase relocates into nuclear foci in response to DNA damaging agents and co-localizes with RPA and Rad51.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154418

Werner's syndrome protein (WRN) migrates Holliday junctions and co-localizes with RPA upon replication arrest

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154418

DNA damage-dependent nuclear dynamics of the Mre11 complex

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154418

Sequence complexity of disordered protein

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154418

The Werner syndrome protein: an update

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154418

Characterization of the human and mouse WRN 3'-->5' exonuclease

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154418

The Werner syndrome gene product co-purifies with the DNA replication complex and interacts with PCNA and topoisomerase I.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154418

Accumulation of premutagenic DNA lesions in mice defective in removal of oxidative base damage

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154418

Functional and physical interaction between WRN helicase and human replication protein A

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154418

Conserved residues of human XPG protein important for nuclease activity and function in nucleotide excision repair

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154418

Postnatal growth failure, short life span, and early onset of cellular senescence and subsequent immortalization in mice lacking the xeroderma pigmentosum group G gene

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154418

Nucleotide excision repair 3' endonuclease XPG stimulates the activity of base excision repairenzyme thymine glycol DNA glycosylase

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154418

The DNA repair endonuclease XPG binds to proliferating cell nuclear antigen (PCNA) and shares sequence elements with the PCNA-binding regions of FEN-1 and cyclin-dependent kinase inhibitor p21

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154418

Translocation of a UV-damaged DNA binding protein into a tight association with chromatin after treatment of mammalian cells with UV light.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154418

Retracted: A common mutational pattern in Cockayne syndrome patients from xeroderma pigmentosum group G: implications for a second XPG function

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154418

Identical defects in DNA repair in xeroderma pigmentosum group G and rodent ERCC group 5

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154418

XPG endonuclease makes the 3' incision in human DNA nucleotide excision repair

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154418

RPA involvement in the damage-recognition and incision steps of nucleotide excision repair

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154418

Mutator phenotype of Werner syndrome is characterized by extensive deletions

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154418

Core filaments of the nuclear matrix

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154418

Biochemical characterization of the WRN-FEN-1 functional interaction

13 July 2018

1 reference

Crossref

https://api.crossref.org/works/10.4161/CC.10.12.15878

The RecQ helicase WRN is required for normal replication fork progression after DNA damage or replication fork arrest

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.4161/CC.10.12.15878

The DNA damage machinery and homologous recombination pathway act consecutively to protect human telomeres

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21558802

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.4161/CC.10.12.15878

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21558802 AND SRC:MED&resulttype=core&format=json

31 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21558802 AND SRC:MED&resulttype=core&format=json

31 January 2020

PubMed publication ID

21558802

1 reference