Engineering high-potency R-spondin adult stem cell growth factors (Q35156403)

6 August 2017

title

Engineering high-potency R-spondin adult stem cell growth factors (English)

1 reference

6 August 2017

1 reference

3

Augen A Pioszak

1 reference

6 August 2017

Margaret L Warner

1

1 reference

6 August 2017

Tufica Bell

series ordinal

2

1 reference

6 August 2017

publication date

12 December 2014

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6 August 2017

published in

Molecular Pharmacology

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6 August 2017

volume

87

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6 August 2017

issue

3

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6 August 2017

page(s)

410-420

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Deciphering key features in protein structures with the new ENDscript server

6 August 2017

cites work

1 reference

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13 July 2018

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Structures of Wnt-Antagonist ZNRF3 and Its Complex with R-Spondin 1 and Implications for Signaling

13 July 2018

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Structural and molecular basis of ZNRF3/RNF43 transmembrane ubiquitin ligase inhibition by the Wnt agonist R-spondin

13 July 2018

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Interaction with both ZNRF3 and LGR4 is required for the signalling activity of R-spondin

13 July 2018

1 reference

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Reconstitution of R-spondin:LGR4:ZNRF3 adult stem cell growth factor signaling complexes with recombinant proteins produced in Escherichia coli

13 July 2018

1 reference

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Induction of intestinal stem cells by R-spondin 1 and Slit2 augments chemoradioprotection

13 July 2018

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Crystal Structures of Lgr4 and Its Complex with R-Spondin1

13 July 2018

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Structure of stem cell growth factor R-spondin 1 in complex with the ectodomain of its receptor LGR5

13 July 2018

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Structural basis for R-spondin recognition by LGR4/5/6 receptors

13 July 2018

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The structural basis of R-spondin recognition by LGR5 and RNF43

13 July 2018

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Growing self-organizing mini-guts from a single intestinal stem cell: mechanism and applications

13 July 2018

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Bacterial expression and purification of a heterodimeric adrenomedullin receptor extracellular domain complex using DsbC-assisted disulfide shuffling

13 July 2018

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The R-spondin family of proteins: emerging regulators of WNT signaling

13 July 2018

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Recurrent R-spondin fusions in colon cancer

13 July 2018

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Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors

13 July 2018

1 reference

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ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner

13 July 2018

1 reference

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The R-spondin protein family

13 July 2018

1 reference

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LGR4 and LGR5 are R-spondin receptors mediating Wnt/β-catenin and Wnt/PCP signalling.

13 July 2018

1 reference

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Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling

13 July 2018

1 reference

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R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling

13 July 2018

1 reference

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The Wnt agonist R-spondin1 regulates systemic graft-versus-host disease by protecting intestinal stem cells.

13 July 2018

1 reference

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A new bioinformatics analysis tools framework at EMBL-EBI.

13 July 2018

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Leucine-rich repeat-containing G-protein-coupled receptors as markers of adult stem cells

13 July 2018

1 reference

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Protective role of R-spondin1, an intestinal stem cell growth factor, against radiation-induced gastrointestinal syndrome in mice

13 July 2018

1 reference

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Structural basis for parathyroid hormone-related protein binding to the parathyroid hormone receptor and design of conformation-selective peptides

13 July 2018

1 reference

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Sustained in vitro intestinal epithelial culture within a Wnt-dependent stem cell niche

13 July 2018

1 reference

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Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

13 July 2018

1 reference

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R-Spondin1 protects mice from chemotherapy or radiation-induced oral mucositis through the canonical Wnt/beta-catenin pathway

13 July 2018

1 reference

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R-Spondin family members regulate the Wnt pathway by a common mechanism

13 July 2018

1 reference

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R-spondin 2 is required for normal laryngeal-tracheal, lung and limb morphogenesis

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4352588

RSPO4 is the major gene in autosomal-recessive anonychia and mutations cluster in the furin-like cysteine-rich domains of the Wnt signaling ligand R-spondin 4.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4352588

Mouse R-spondin2 is required for apical ectodermal ridge maintenance in the hindlimb

13 July 2018

1 reference

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Mutations in R-spondin 4 (RSPO4) underlie inherited anonychia

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4352588

The gene encoding R-spondin 4 (RSPO4), a secreted protein implicated in Wnt signaling, is mutated in inherited anonychia

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4352588

R-spondin1 is essential in sex determination, skin differentiation and malignancy.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4352588

A time- and cost-efficient system for high-level protein production in mammalian cells

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4352588

R-spondin3 is required for mouse placental development

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4352588

R-Spondin proteins: a novel link to beta-catenin activation

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4352588

Mitogenic influence of human R-spondin1 on the intestinal epithelium

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4352588

R-Spondin2 is a secreted activator of Wnt/beta-catenin signaling and is required for Xenopus myogenesis

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4352588

R-spondin1, a novel intestinotrophic mitogen, ameliorates experimental colitis in mice.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4352588

Rspo3 Binds Syndecan 4 and Induces Wnt/PCP Signaling via Clathrin-Mediated Endocytosis to Promote Morphogenesis

27 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25504990

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25504990

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1124/MOL.114.095133

1 reference

6 August 2017

1 reference

6 August 2017

1 reference