Involvement of metformin and AMPK in the radioresponse and prognosis of luminal versus basal-like breast cancer treated with radiotherapy (Q35149589)

25427448

6 August 2017

title

Involvement of metformin and AMPK in the radioresponse and prognosis of luminal versus basal-like breast cancer treated with radiotherapy (English)

1 reference

25427448

adaptive radiation therapy

6 August 2017

main subject

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2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25427448 AND SRC:MED&resulttype=core&format=json

9 June 2020

Andrew Green

4

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25427448 AND SRC:MED&resulttype=core&format=json

9 June 2020

Emad A. Rakha

5

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25427448 AND SRC:MED&resulttype=core&format=json

9 June 2020

Ian Ellis

6

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9 June 2020

Stewart Martin

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9 June 2020

author name string

Yimin Zhang

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25427448 AND SRC:MED&resulttype=core&format=json

9 June 2020

Kerstie Johnson

3

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9 June 2020

David A L Morgan

7

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9 June 2020

language of work or name

English

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publication date

1 December 2014

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6 August 2017

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9 June 2020

volume

5

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25427448 AND SRC:MED&resulttype=core&format=json

9 June 2020

issue

24

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9 June 2020

page(s)

12936-12949

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25427448 AND SRC:MED&resulttype=core&format=json

Metformin sensitizes prostate cancer cells to radiation through EGFR/p-DNA-PKCS in vitro and in vivo.

9 June 2020

cites work

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13 July 2018

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Metformin does not affect risk of biochemical recurrence following radical prostatectomy: results from the SEARCH database.

13 July 2018

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AMP-Activated Protein Kinase α 2 Isoform Suppression in Primary Breast Cancer Alters AMPK Growth Control and Apoptotic Signaling

13 July 2018

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Effect of metformin on prostate cancer outcomes after radical prostatectomy

13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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Metformin reduces endogenous reactive oxygen species and associated DNA damage

13 July 2018

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Ionizing radiation regulates the expression of AMP-activated protein kinase (AMPK) in epithelial cancer cells: modulation of cellular signals regulating cell cycle and survival

13 July 2018

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AMP-activated protein kinase (AMPK) mediates nutrient regulation of thioredoxin-interacting protein (TXNIP) in pancreatic beta-cells

13 July 2018

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Metformin and thiazolidinediones are associated with improved breast cancer-specific survival of diabetic women with HER2 breast cancer.

13 July 2018

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Effect of metformin on survival outcomes in diabetic patients with triple receptor‐negative breast cancer

13 July 2018

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Metformin suppresses ovarian cancer growth and metastasis with enhancement of cisplatin cytotoxicity in vivo.

13 July 2018

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Type 2 diabetes increases and metformin reduces total, colorectal, liver and pancreatic cancer incidences in Taiwanese: a representative population prospective cohort study of 800,000 individuals

13 July 2018

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Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes

13 July 2018

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Ionizing radiation activates AMP-activated kinase (AMPK): a target for radiosensitization of human cancer cells

13 July 2018

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The biological, clinical and prognostic implications of p53 transcriptional pathways in breast cancers

13 July 2018

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Histological evaluation of AMPK signalling in primary breast cancer

13 July 2018

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The LKB1-AMPK pathway: metabolism and growth control in tumour suppression

13 July 2018

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13 July 2018

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New users of metformin are at low risk of incident cancer: a cohort study among people with type 2 diabetes

13 July 2018

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Metformin and pathologic complete responses to neoadjuvant chemotherapy in diabetic patients with breast cancer

13 July 2018

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Metformin induces unique biological and molecular responses in triple negative breast cancer cells

13 July 2018

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13 July 2018

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Basal phenotype identifies a poor prognostic subgroup of breast cancer of clinical importance

13 July 2018

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13 July 2018

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13 July 2018

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Identification of phosphorylation sites in AMP-activated protein kinase (AMPK) for upstream AMPK kinases and study of their roles by site-directed mutagenesis

13 July 2018

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Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications

13 July 2018

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13 July 2018

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13 July 2018

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Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4350336

Identification of thioredoxin-binding protein-2/vitamin D(3) up-regulated protein 1 as a negative regulator of thioredoxin function and expression

13 July 2018

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13 July 2018

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Resistance to Dasatinib in primary chronic lymphocytic leukemia lymphocytes involves AMPK-mediated energetic re-programming

13 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4350336

Clinical pathological characteristics and prognostic analysis of diabetic women with luminal subtype breast cancer

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4350336

Metformin use and all-cause and prostate cancer-specific mortality among men with diabetes

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4350336

AMP-activated protein kinase signaling is upregulated in papillary thyroid cancer.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4350336

Association of metformin use with cancer incidence and mortality: a meta-analysis.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4350336

Dual effect of metformin on breast cancer proliferation in a randomized presurgical trial

27 September 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4350336

A potential mechanism of metformin-mediated regulation of glucose homeostasis: inhibition of Thioredoxin-interacting protein (Txnip) gene expression.

27 September 2018

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27 September 2018

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AMPK regulates metabolism and survival in response to ionizing radiation

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4350336

AMP-activated protein kinase: a cellular energy sensor with a key role in metabolic disorders and in cancer.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4350336

Metformin reduces intracellular reactive oxygen species levels by upregulating expression of the antioxidant thioredoxin via the AMPK-FOXO3 pathway

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4350336

REporting recommendations for tumor MARKer prognostic studies (REMARK).

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4350336

Expression of thioredoxin system and related peroxiredoxin proteins is associated with clinical outcome in radiotherapy treated early stage breast cancer

27 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25427448

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Association of diabetes mellitus and metformin use with biochemical recurrence in patients treated with radical prostatectomy for prostate cancer

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25427448

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.18632/ONCOTARGET.2683

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25427448 AND SRC:MED&resulttype=core&format=json

9 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25427448 AND SRC:MED&resulttype=core&format=json

9 June 2020

25427448

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25427448 AND SRC:MED&resulttype=core&format=json