Ketogenesis prevents diet-induced fatty liver injury and hyperglycemia (Q35145496)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25347470 AND SRC:MED&resulttype=core&format=json

21 February 2020

title

Ketogenesis prevents diet-induced fatty liver injury and hyperglycemia (English)

1 reference

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21 February 2020

1 reference

10

1 reference

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21 February 2020

8

Elizabeth M Brunt

1 reference

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21 February 2020

author name string

David G Cotter

1

1 reference

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21 February 2020

Baris Ercal

2

1 reference

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21 February 2020

Xiaojing Huang

3

1 reference

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21 February 2020

Jamison M Leid

4

1 reference

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21 February 2020

D André d'Avignon

5

1 reference

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21 February 2020

Mark J Graham

6

1 reference

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21 February 2020

Dennis J Dietzen

7

1 reference

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21 February 2020

Gary J Patti

9

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21 February 2020

language of work or name

English

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publication date

27 October 2014

1 reference

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Journal of Clinical Investigation

21 February 2020

published in

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21 February 2020

volume

124

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21 February 2020

issue

12

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21 February 2020

page(s)

5175-5190

1 reference

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Inflammation triggers production of dimethylsphingosine from oligodendrocytes.

21 February 2020

cites work

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A nuclear pyruvate dehydrogenase complex is important for the generation of acetyl-CoA and histone acetylation

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Impairments of hepatic gluconeogenesis and ketogenesis in PPARα-deficient neonatal mice

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Nucleocytosolic depletion of the energy metabolite acetyl-coenzyme a stimulates autophagy and prolongs lifespan

13 July 2018

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13 July 2018

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13 July 2018

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Direct assessment of hepatic mitochondrial oxidative and anaplerotic fluxes in humans using dynamic 13C magnetic resonance spectroscopy

13 July 2018

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SIRT5 regulates the mitochondrial lysine succinylome and metabolic networks

13 July 2018

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13 July 2018

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13 July 2018

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Role of choline deficiency in the Fatty liver phenotype of mice fed a low protein, very low carbohydrate ketogenic diet

13 July 2018

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Toward 'omic scale metabolite profiling: a dual separation-mass spectrometry approach for coverage of lipid and central carbon metabolism

13 July 2018

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Impact of peripheral ketolytic deficiency on hepatic ketogenesis and gluconeogenesis during the transition to birth.

13 July 2018

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Association of ketone body levels with hyperglycemia and type 2 diabetes in 9,398 Finnish men.

13 July 2018

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Progression of NAFLD to diabetes mellitus, cardiovascular disease or cirrhosis

13 July 2018

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Ketone body metabolism and cardiovascular disease

13 July 2018

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Nonalcoholic fatty liver disease: an emerging threat to obese and diabetic individuals

13 July 2018

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Clinical Review: Nonalcoholic fatty liver disease: a novel cardiometabolic risk factor for type 2 diabetes and its complications.

13 July 2018

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Successful adaptation to ketosis by mice with tissue-specific deficiency of ketone body oxidation

13 July 2018

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A quantitative map of the liver mitochondrial phosphoproteome reveals posttranslational control of ketogenesis

13 July 2018

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Dissociating fatty liver and diabetes

13 July 2018

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An accelerated workflow for untargeted metabolomics using the METLIN database

13 July 2018

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Germline deletion of pantothenate kinases 1 and 2 reveals the key roles for CoA in postnatal metabolism

13 July 2018

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Effect of diet composition on coenzyme A and its thioester pools in various rat tissues

13 July 2018

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Interplay between lipids and branched-chain amino acids in development of insulin resistance

13 July 2018

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The problem of establishing relationships between hepatic steatosis and hepatic insulin resistance

13 July 2018

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13 July 2018

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Elevated TCA cycle function in the pathology of diet-induced hepatic insulin resistance and fatty liver

13 July 2018

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Mechanisms for insulin resistance: common threads and missing links

13 July 2018

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Excessive hepatic mitochondrial TCA cycle and gluconeogenesis in humans with nonalcoholic fatty liver disease

13 July 2018

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Flux through hepatic pyruvate carboxylase and phosphoenolpyruvate carboxykinase detected by hyperpolarized 13C magnetic resonance

13 July 2018

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Hormonal regulation of hepatic glucose production in health and disease

13 July 2018

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13 July 2018

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Human HMGCS2 regulates mitochondrial fatty acid oxidation and FGF21 expression in HepG2 cell line

13 July 2018

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Mitochondrial dysfunction in nonalcoholic steatohepatitis

13 July 2018

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Obligate role for ketone body oxidation in neonatal metabolic homeostasis

13 July 2018

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mTORC1 controls fasting-induced ketogenesis and its modulation by ageing.

13 July 2018

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SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production

13 July 2018

1 reference

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Risk of Cardiovascular Disease in Patients with Nonalcoholic Fatty Liver Disease

13 July 2018

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Pantothenate kinase 1 is required to support the metabolic transition from the fed to the fasted state

13 July 2018

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Adaptation of myocardial substrate metabolism to a ketogenic nutrient environment

13 July 2018

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Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance.

13 July 2018

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Early hepatic insulin resistance in mice: a metabolomics analysis

13 July 2018

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Palmitoylation of ketogenic enzyme HMGCS2 enhances its interaction with PPARalpha and transcription at the Hmgcs2 PPRE.

13 July 2018

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13 July 2018

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13 July 2018

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Identification of a physiologically relevant endogenous ligand for PPARalpha in liver

13 July 2018

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Lysine acetylation targets protein complexes and co-regulates major cellular functions

13 July 2018

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Regulation of myocardial ketone body metabolism by the gut microbiota during nutrient deprivation

13 July 2018

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ATP-citrate lyase links cellular metabolism to histone acetylation

13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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Nonalcoholic fatty liver disease and mitochondrial dysfunction

13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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Genetic basis of mitochondrial HMG-CoA synthase deficiency

13 July 2018

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13 July 2018

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Atypical expression of mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase in subcutaneous adipose tissue of male rats

13 July 2018

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Structure, function and regulation of pyruvate carboxylase

13 July 2018

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Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase: a control enzyme in ketogenesis

13 July 2018

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A mitochondrial ketogenic enzyme regulates its gene expression by association with the nuclear hormone receptor PPARalpha

13 July 2018

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Physiological roles of ketone bodies as substrates and signals in mammalian tissues

13 July 2018

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Regulation of hepatic fatty acid oxidation and ketone body production

13 July 2018

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Activities of enzymes involved in acetoacetate utilization in adult mammalian tissues

13 July 2018

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Glucagon activates mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase in vivo by decreasing the extent of succinylation of the enzyme

13 July 2018

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Amelioration of adverse effects of valproic acid on ketogenesis and liver coenzyme A metabolism by cotreatment with pantothenate and carnitine in developing mice: possible clinical significance

13 July 2018

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Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase deficiency: clinical course and description of causal mutations in two patients

13 July 2018

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28 July 2018

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New case of mitochondrial HMG-CoA synthase deficiency. Functional analysis of eight mutations

27 September 2018

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Effects of insulin on ketogenesis following fasting in lean and obese men.

27 September 2018

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Adipose tissue fatty acid metabolism in insulin-resistant men.

27 September 2018

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Effects of fasting on insulin action and glucose kinetics in lean and obese men and women

27 September 2018

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Ketone body metabolism in lean and obese women

27 September 2018

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Hepatic mitochondrial 3-hydroxy-3-methylglutaryl-coenzyme a synthase deficiency

27 September 2018

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Fasting hypoketotic coma in a child with deficiency of mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase.

27 September 2018

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Control mechanisms of gluconeogenesis and ketogenesis. I. Effects of oleate on gluconeogenesis in perfused rat liver.

27 September 2018

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Mitochondrial HMG-CoA synthase deficiency: identification of two further patients carrying two novel mutations

27 September 2018

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Effects of hepatotoxic doses of acetaminophen and furosemide on tissue concentrations of CoASH and CoASSG in vivo

27 September 2018

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12 December 2020

The inhibitory effects of acyl-coenzyme a esters on the pyruvate and α-oxoglutarate dehydrogenase complexes

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12 December 2020

Control mechanisms of gluconeogenesis and ketogenesis. II. Interactions between fatty acid oxidation and the citric acid cycle in perfused rat liver

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12 December 2020

Control factors affecting gluconeogenesis in perfused rat liver. Effects of 4-pentenoic acid

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12 December 2020

Reversal of the adverse chronic effects of the unsaturated derivative of valproic acid--2-n-propyl-4-pentenoic acid--on ketogenesis and liver coenzyme A metabolism by a single injection of pantothenate, carnitine, and acetylcysteine in developing mi

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12 December 2020

Determination of acetyl-CoA enrichment in rat heart and skeletal muscle by 1H nuclear magnetic resonance analysis of glutamate in tissue extracts

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12 December 2020

Identifiers

DOI

10.1172/JCI76388

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25347470 AND SRC:MED&resulttype=core&format=json

21 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25347470 AND SRC:MED&resulttype=core&format=json

21 February 2020

PubMed publication ID

25347470

1 reference