A small-molecule IAP inhibitor overcomes resistance to cytotoxic therapies in malignant gliomas in vitro and in vivo (Q35133408)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21724651 AND SRC:MED&resulttype=core&format=json

6 February 2020

title

A small-molecule IAP inhibitor overcomes resistance to cytotoxic therapies in malignant gliomas in vitro and in vivo (English)

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6 February 2020

1

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6 February 2020

Mark W. Kieran

8

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6 February 2020

Andrew L. Kung

10

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6 February 2020

4

Eva M Fast

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6 February 2020

author name string

Joanna Keating

2

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6 February 2020

Santosh Kesari

3

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6 February 2020

Leigh Zawel

5

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6 February 2020

Naren Ramakrishna

6

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6 February 2020

Jessica Barnes

7

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6 February 2020

Sophie E M Veldhuijzen van Zanten

9

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6 February 2020

publication date

1 July 2011

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6 February 2020

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6 February 2020

volume

13

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6 February 2020

issue

8

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6 February 2020

page(s)

820-829

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Small-molecule XIAP inhibitors enhance gamma-irradiation-induced apoptosis in glioblastoma

6 February 2020

cites work

1 reference

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Resistance of human glioblastoma multiforme cells to growth factor inhibitors is overcome by blockade of inhibitor of apoptosis proteins

13 July 2018

1 reference

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Malignant gliomas in adults

13 July 2018

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Anti-apoptosis mechanisms in malignant gliomas.

13 July 2018

1 reference

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A Smac mimetic rescue screen reveals roles for inhibitor of apoptosis proteins in tumor necrosis factor-alpha signaling

13 July 2018

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Therapeutic targeting of apoptosis pathways in cancer.

13 July 2018

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IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis

13 July 2018

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Potentiation of antileukemic therapies by Smac mimetic, LBW242: effects on mutant FLT3-expressing cells

13 July 2018

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Olig2-regulated lineage-restricted pathway controls replication competence in neural stem cells and malignant glioma

13 July 2018

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Bcl2L12 inhibits post-mitochondrial apoptosis signaling in glioblastoma

13 July 2018

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Glioma stem cells promote radioresistance by preferential activation of the DNA damage response

13 July 2018

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Targeting mitochondrial factor Smac/DIABLO as therapy for multiple myeloma (MM)

13 July 2018

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Synthetic Smac peptide enhances the effect of etoposide-induced apoptosis in human glioblastoma cell lines

13 July 2018

1 reference

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Noninvasive bioluminescence imaging of luciferase expressing intracranial U87 xenografts: correlation with magnetic resonance imaging determined tumor volume and longitudinal use in assessing tumor growth and antiangiogenic treatment effect

13 July 2018

1 reference

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Efficacy of vincristine and etoposide with escalating cyclophosphamide in poor-prognosis pediatric brain tumors

13 July 2018

1 reference

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Sensitization for gamma-irradiation-induced apoptosis by second mitochondria-derived activator of caspase

13 July 2018

1 reference

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Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors.

13 July 2018

1 reference

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Angiogenesis and apoptosis in glioma: two arenas for promising new therapies

13 July 2018

1 reference

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Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma

13 July 2018

1 reference

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Identification of human brain tumour initiating cells

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3145470

A small molecule Smac mimic potentiates TRAIL- and TNFalpha-mediated cell death

13 July 2018

1 reference

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Supratentorial high-grade astrocytoma and diffuse brainstem glioma: two challenges for the pediatric oncologist

13 July 2018

1 reference

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X-linked inhibitor regulating TRAIL-induced apoptosis in chemoresistant human primary glioblastoma cells

13 July 2018

1 reference

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A small-molecule antagonist of CXCR4 inhibits intracranial growth of primary brain tumors.

13 July 2018

1 reference

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Smac agonists sensitize for Apo2L/TRAIL- or anticancer drug-induced apoptosis and induce regression of malignant glioma in vivo

13 July 2018

1 reference

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Quantitatively determined survivin expression levels are of prognostic value in human gliomas

13 July 2018

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Intracranial inhibition of platelet-derived growth factor-mediated glioblastoma cell growth by an orally active kinase inhibitor of the 2-phenylaminopyrimidine class.

13 July 2018

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Antagonists of growth hormone-releasing hormone inhibit the growth of U-87MG human glioblastoma in nude mice.

13 July 2018

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A human IAP-family gene, apollon, expressed in human brain cancer cells

13 July 2018

1 reference

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Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors

13 July 2018

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Expression of two types of receptor for insulin-like growth factors in human malignant glioma.

13 July 2018

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Amplification and/or overexpression of platelet-derived growth factor receptors and epidermal growth factor receptor in human glial tumors

13 July 2018

1 reference

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Platelet-derived growth factor and its receptors in human glioma tissue: expression of messenger RNA and protein suggests the presence of autocrine and paracrine loops

13 July 2018

1 reference

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Expression and biological activity of X-linked inhibitor of apoptosis (XIAP) in human malignant glioma

13 July 2018

1 reference

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Expression of PDGF and PDGF receptors in human astrocytoma operation specimens supports the existence of an autocrine loop.

27 September 2018

1 reference

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Apoptosis in gliomas: molecular mechanisms and therapeutic implications

27 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1093/NEUONC/NOR066

Tumor response to radiotherapy regulated by endothelial cell apoptosis

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21724651

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1093/NEUONC/NOR066

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21724651 AND SRC:MED&resulttype=core&format=json

6 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21724651 AND SRC:MED&resulttype=core&format=json

6 February 2020

PubMed publication ID

21724651

1 reference