Fumarate induces redox-dependent senescence by modifying glutathione metabolism (Q35121732)

6 August 2017

title

Fumarate induces redox-dependent senescence by modifying glutathione metabolism (English)

1 reference

6 August 2017

1 reference

Karen Blyth

14

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RuAngelie Edrada-Ebel

RuAngelie Edrada-Ebel

10

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Eyal Gottlieb

Eyal Gottlieb

17

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Christian Frezza

Christian Frezza

16

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Eytan Ruppin

15

Eytan Ruppin

1 reference

6 August 2017

Liang Zheng

1

1 reference

6 August 2017

Simone Cardaci

2

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6 August 2017

Livnat Jerby

3

1 reference

6 August 2017

Elaine D MacKenzie

4

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6 August 2017

Marco Sciacovelli

5

1 reference

6 August 2017

T Isaac Johnson

6

1 reference

6 August 2017

Edoardo Gaude

7

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6 August 2017

Ayala King

8

1 reference

6 August 2017

Joshua D G Leach

9

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6 August 2017

Ann Hedley

11

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6 August 2017

Nicholas A Morrice

12

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6 August 2017

Gabriela Kalna

13

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6 August 2017

language of work or name

English

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publication date

23 January 2015

1 reference

6 August 2017

published in

Nature Communications

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6 August 2017

volume

6

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6 August 2017

page(s)

6001

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Creative Commons Attribution 4.0 International

6 August 2017

copyright license

start time

23 January 2015

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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Renal cyst formation in Fh1-deficient mice is independent of the Hif/Phd pathway: roles for fumarate in KEAP1 succination and Nrf2 signaling

9 July 2018

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Aberrant succination of proteins in fumarate hydratase-deficient mice and HLRCC patients is a robust biomarker of mutation status

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UOK 262 cell line, fumarate hydratase deficient (FH-/FH-) hereditary leiomyomatosis renal cell carcinoma: in vitro and in vivo model of an aberrant energy metabolic pathway in human cancer

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Nrf2:INrf2 (Keap1) signaling in oxidative stress

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Fumarate hydratase deficiency in renal cancer induces glycolytic addiction and hypoxia-inducible transcription factor 1alpha stabilization by glucose-dependent generation of reactive oxygen species.

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Targeted inactivation of fh1 causes proliferative renal cyst development and activation of the hypoxia pathway

9 July 2018

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9 July 2018

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HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability

9 July 2018

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9 July 2018

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Inducible Cre-mediated control of gene expression in the murine gastrointestinal tract: effect of loss of beta-catenin

9 July 2018

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9 July 2018

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Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer

9 July 2018

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9 July 2018

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9 July 2018

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9 July 2018

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Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

9 July 2018

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VHL loss actuates a HIF-independent senescence programme mediated by Rb and p400.

9 July 2018

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Accumulation of Krebs cycle intermediates and over-expression of HIF1alpha in tumours which result from germline FH and SDH mutations

27 September 2018

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The extended catalysis of glutathione transferase

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iMAT: an integrative metabolic analysis tool

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PubMed

https://pubmed.ncbi.nlm.nih.gov/25613188

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Network-based prediction of human tissue-specific metabolism

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PubMed

https://pubmed.ncbi.nlm.nih.gov/25613188

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NCOMMS7001

1 reference

6 August 2017

0 references

1 reference

6 August 2017

1 reference