Novel pathway of ceramide production in mitochondria: thioesterase and neutral ceramidase produce ceramide from sphingosine and acyl-CoA. (Q35107592)

6 August 2017

title

Novel pathway of ceramide production in mitochondria: thioesterase and neutral ceramidase produce ceramide from sphingosine and acyl-CoA. (English)

1 reference

N-acylsphingosine amidohydrolase 2

6 August 2017

main subject

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GOA release 2020-03-11

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6

Yusuf A Hannun

1 reference

6 August 2017

Sergei A Novgorodov

1

1 reference

6 August 2017

Bill X Wu

2

1 reference

6 August 2017

Tatyana I Gudz

3

1 reference

6 August 2017

Jacek Bielawski

4

1 reference

6 August 2017

Tatiana V Ovchinnikova

5

1 reference

6 August 2017

Lina M Obeid

7

1 reference

6 August 2017

language of work or name

English

0 references

publication date

25 May 2011

1 reference

Journal of Biological Chemistry

6 August 2017

published in

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6 August 2017

volume

286

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6 August 2017

issue

28

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6 August 2017

page(s)

25352-25362

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describes a project that uses

6 August 2017

ImageQuant

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3137106/fullTextXML

inferred from PubMed Central ID database lookup

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9 July 2018

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9 July 2018

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9 July 2018

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9 July 2018

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9 July 2018

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9 July 2018

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9 July 2018

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Purification and Characterization of Long-Chain Acyl-CoA Hydrolase from Rat Liver Mitochondria

9 July 2018

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Dual Localization of Long-Chain Acyl-CoA Hydrolase in Rat Liver: One in the Microsomes and One in the Mitochondrial Matrix

9 July 2018

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Isolation, properties, and regulation of a mitochondrial acyl coenzyme A thioesterase from pig heart

9 July 2018

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9 July 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Ceramide induces release of pro-apoptotic proteins from mitochondria by either a Ca2 -dependent or a Ca2 -independent mechanism

21 January 2018

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Acid sphingomyelinase is indispensable for UV light-induced Bax conformational change at the mitochondrial membrane

21 January 2018

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JNK3 signaling pathway activates ceramide synthase leading to mitochondrial dysfunction

21 January 2018

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https://api.crossref.org/works/10.1074/JBC.M110.214866

Ceramide biogenesis is required for radiation-induced apoptosis in the germ line of C. elegans

21 January 2018

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https://api.crossref.org/works/10.1074/JBC.M110.214866

Ceramide synthesis in the endoplasmic reticulum can permeabilize mitochondria to proapoptotic proteins.

21 January 2018

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C-Myc is a Nrf2-interacting protein that negatively regulates phase II genes through their electrophile responsive elements

21 January 2018

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Purification and characterization of a neutral ceramidase from mouse liver. A single protein catalyzes the reversible reaction in which ceramide is both hydrolyzed and synthesized

21 January 2018

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Biochemical characterization of the reverse activity of rat brain ceramidase. A CoA-independent and fumonisin B1-insensitive ceramide synthase

21 January 2018

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Neutral ceramidase encoded by the Asah2 gene is essential for the intestinal degradation of sphingolipids

21 January 2018

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Combination of C(17) sphingoid base homologues and mass spectrometry analysis as a new approach to study sphingolipid metabolism

21 January 2018

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Large-scale purification and characterization of recombinant Pseudomonas ceramidase: regulation by calcium.

21 January 2018

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Structural requirements of ceramide and sphingosine based inhibitors of mitochondrial ceramidase

21 January 2018

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Concerted regulation of free arachidonic acid and hormone-induced steroid synthesis by acyl-CoA thioesterases and acyl-CoA synthetases in adrenal cells

21 January 2018

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O-glycosylation of mucin-like domain retains the neutral ceramidase on the plasma membranes as a type II integral membrane protein

21 January 2018

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Purification, characterization, molecular cloning, and subcellular distribution of neutral ceramidase of rat kidney

21 January 2018

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Enzymic hydrolysis of sphingolipids. VIII. Purification and properties of rat brain ceramidase

21 January 2018

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Silencing the expression of mitochondrial acyl-CoA thioesterase I and acyl-CoA synthetase 4 inhibits hormone-induced steroidogenesis

21 January 2018

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tBid induces alterations of mitochondrial fatty acid oxidation flux by malonyl-CoA-independent inhibition of carnitine palmitoyltransferase-1.

21 January 2018

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https://api.crossref.org/works/10.1074/JBC.M110.214866

Selective hydrolysis of a mitochondrial pool of sphingomyelin induces apoptosis

21 January 2018

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https://api.crossref.org/works/10.1074/JBC.M110.214866

Improved methods to isolate and subfractionate rat liver mitochondria. Lipid composition of the inner and outer membrane

21 January 2018

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https://api.crossref.org/works/10.1074/JBC.M110.214866

Direct Effect of Ceramide on the Mitochondrial Electron Transport Chain Leads to Generation of Reactive Oxygen Species

21 January 2018

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https://api.crossref.org/works/10.1074/JBC.M110.214866

Pharmacological inhibition or small interfering RNA targeting acid ceramidase sensitizes hepatoma cells to chemotherapy and reduces tumor growth in vivo

21 January 2018

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https://api.crossref.org/works/10.1074/JBC.M110.214866

Ceramide Induces CytochromecRelease from Isolated Mitochondria

21 January 2018

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https://api.crossref.org/works/10.1074/JBC.M110.214866

Fatty acid flip-flop in phospholipid bilayers is extremely fast

21 January 2018

1 reference

12 December 2020

(1S,2R)-D-erythro-2-(N-myristoylamino)-1-phenyl-1-propanol as an inhibitor of ceramidase

1 reference

12 December 2020

Direct Inhibition of Mitochondrial Respiratory Chain Complex III by Cell-permeable Ceramide

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12 December 2020

Simultaneous quantitative analysis of bioactive sphingolipids by high-performance liquid chromatography-tandem mass spectrometry

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12 December 2020

Activation of a novel long-chain free fatty acid generation and export system in mitochondria of diabetic rat hearts

1 reference

12 December 2020

Functional consequences of the sustained or transient activation by Bax of the mitochondrial permeability transition pore

1 reference

12 December 2020

Ceramide Interaction with the Respiratory Chain of Heart Mitochondria†

1 reference

12 December 2020

Free fatty-acid uptake by isolated rat hepatocytes

1 reference

12 December 2020

Ion channel formation by zervamicin-IIB. A molecular modelling study

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M110.214866

1 reference

6 August 2017

1 reference

6 August 2017

1 reference