Aldo-keto reductase 1B7 is a target gene of FXR and regulates lipid and glucose homeostasis (Q35107308)

6 August 2017

title

Aldo-keto reductase 1B7 is a target gene of FXR and regulates lipid and glucose homeostasis (English)

1 reference

6 August 2017

5

John Y. L. Chiang

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:21642744

3 December 2024

author name string

Xuemei Ge

1

1 reference

6 August 2017

Liya Yin

2

1 reference

6 August 2017

Huiyan Ma

3

1 reference

6 August 2017

Tiangang Li

4

1 reference

6 August 2017

Yanqiao Zhang

6

1 reference

6 August 2017

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=21642744

3 December 2024

publication date

5 June 2011

1 reference

full work available at URL

6 August 2017

http://www.jlr.org/article/S0022227520369327/pdf

file format

Portable Document Format

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:21642744

https://europepmc.org/articles/PMC3137022

3 December 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:21642744

https://europepmc.org/articles/PMC3137022?pdf=render

3 December 2024

file format

Portable Document Format

online access status

open access

content deliverer

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:21642744

https://doi.org/10.1194/jlr.m015859

3 December 2024

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:21642744

https://api.elsevier.com/content/article/PII:S0022227520369327?httpAccept=text/xml

3 December 2024

1 reference

https://api.elsevier.com/content/article/PII:S0022227520369327?httpAccept=text/plain

3 December 2024

1 reference

https://syndication.highwire.org/content/doi/10.1194/jlr.M015859

3 December 2024

1 reference

Journal of Lipid Research

3 December 2024

published in

1 reference

6 August 2017

volume

52

1 reference

6 August 2017

issue

8

1 reference

6 August 2017

page(s)

1561-1568

1 reference

AKR1B7 is induced by the farnesoid X receptor and metabolizes bile acids

6 August 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137022

Hepatic Hepatocyte Nuclear Factor 4α Is Essential for Maintaining Triglyceride and Cholesterol Homeostasis

9 July 2018

1 reference

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Identification of novel pathways that control farnesoid X receptor-mediated hypocholesterolemia

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137022

Activation of farnesoid X receptor prevents atherosclerotic lesion formation in LDLR-/- and apoE-/- mice

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137022

Discovery of XL335 (WAY-362450), a highly potent, selective, and orally active agonist of the farnesoid X receptor (FXR)

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137022

Farnesoid X receptor deficiency in mice leads to increased intestinal epithelial cell proliferation and tumor development

9 July 2018

1 reference

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Routes to 4-hydroxynonenal: fundamental issues in the mechanisms of lipid peroxidation

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137022

FXR signaling in metabolic disease

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137022

Reactive electrophile species

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137022

AKR1B7 (mouse vas deferens protein) is dispensable for mouse development and reproductive success.

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137022

Spontaneous hepatocarcinogenesis in farnesoid X receptor-null mice

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137022

Coordinated control of bile acids and lipogenesis through FXR-dependent regulation of fatty acid synthase

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137022

Farnesoid X receptor is essential for normal glucose homeostasis

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137022

Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137022

Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137022

FXR regulates organic solute transporters alpha and beta in the adrenal gland, kidney, and intestine

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137022

A farnesoid x receptor-small heterodimer partner regulatory cascade modulates tissue metalloproteinase inhibitor-1 and matrix metalloprotease expression in hepatic stellate cells and promotes resolution of liver fibrosis

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137022

Regulation of the aldo-keto reductase gene akr1b7 by the nuclear oxysterol receptor LXRalpha (liver X receptor-alpha) in the mouse intestine: putative role of LXRs in lipid detoxification processes

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137022

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137022

Natural structural variants of the nuclear receptor farnesoid X receptor affect transcriptional activation

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137022

Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137022

Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137022

Product of side-chain cleavage of cholesterol, isocaproaldehyde, is an endogenous specific substrate of mouse vas deferens protein, an aldose reductase-like protein in adrenocortical cells

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137022

Tissue-specific expression of two aldose reductase-like genes in mice: abundant expression of mouse vas deferens protein and fibroblast growth factor-regulated protein in the adrenal gland

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137022

Altered bile acid profiles in duodenal bile and urine in diabetic subjects

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137022

Antiatherosclerotic effect of farnesoid X receptor

9 July 2018

1 reference

Farnesoid X receptor agonist WAY-362450 attenuates liver inflammation and fibrosis in murine model of non-alcoholic steatohepatitis.

21 January 2018

1 reference

Spontaneous development of liver tumors in the absence of the bile acid receptor farnesoid X receptor

21 January 2018

1 reference

The aldo-keto reductase Akr1b7 gene is a common transcriptional target of xenobiotic receptors pregnane X receptor and constitutive androstane receptor

21 January 2018

1 reference

Altered bile acid metabolism in nonobese, spontaneously diabetic (NOD) mice

21 January 2018

1 reference

Bile acid pool changes and regulation of cholate synthesis in experimental diabetes

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21642744

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Specific changes of bile acid metabolism in spontaneously diabetic Wistar rats

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21642744

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Nuclear receptor-dependent bile acid signaling is required for normal liver regeneration

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21642744

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

23

1 reference

3 December 2024

Identifiers

DOI

10.1194/JLR.M015859

1 reference

6 August 2017

1 reference

6 August 2017

1 reference