A novel strategy to inhibit FAK and IGF-1R decreases growth of pancreatic cancer xenografts (Q35104400)

6 August 2017

title

A novel strategy to inhibit FAK and IGF-1R decreases growth of pancreatic cancer xenografts (English)

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6 August 2017

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Donghang Zheng

1

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6 August 2017

Vita Golubovskaya

2

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6 August 2017

Elena Kurenova

3

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6 August 2017

Cheng Wood

4

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6 August 2017

Nicole A Massoll

5

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6 August 2017

David Ostrov

6

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6 August 2017

William G Cance

7

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6 August 2017

Steven N Hochwald

8

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6 August 2017

publication date

1 February 2010

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6 August 2017

published in

Molecular Carcinogenesis

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6 August 2017

volume

49

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6 August 2017

issue

2

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6 August 2017

page(s)

200-209

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A novel small molecule inhibitor of FAK decreases growth of human pancreatic cancer.

6 August 2017

cites work

1 reference

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A small molecule inhibitor, 1,2,4,5-benzenetetraamine tetrahydrochloride, targeting the y397 site of focal adhesion kinase decreases tumor growth

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FAK and IGF-IR interact to provide survival signals in human pancreatic adenocarcinoma cells

9 July 2018

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Inhibition of both focal adhesion kinase and insulin-like growth factor-I receptor kinase suppresses glioma proliferation in vitro and in vivo

9 July 2018

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A novel low-molecular weight inhibitor of focal adhesion kinase, TAE226, inhibits glioma growth

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9 July 2018

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Regulation of hypoxia-inducible factor-1alpha, vascular endothelial growth factor, and angiogenesis by an insulin-like growth factor-I receptor autocrine loop in human pancreatic cancer

9 July 2018

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MEK kinase 1 interacts with focal adhesion kinase and regulates insulin receptor substrate-1 expression

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Role of focal adhesion kinase in MAP kinase activation by insulin-like growth factor-I or insulin

9 July 2018

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9 July 2018

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Multiple Grb2-mediated integrin-stimulated signaling pathways to ERK2/mitogen-activated protein kinase: summation of both c-Src- and focal adhesion kinase-initiated tyrosine phosphorylation events

9 July 2018

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p125Fak focal adhesion kinase is a substrate for the insulin and insulin-like growth factor-I tyrosine kinase receptors

9 July 2018

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Altered Expression of Insulin-like Growth Factor II Receptor in Human Pancreatic Cancer

9 July 2018

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Control of adhesion-dependent cell survival by focal adhesion kinase

9 July 2018

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Increased expression of insulin receptor substrate-1 in human pancreatic cancer

9 July 2018

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Insulin-like growth factor I overexpression in human pancreatic cancer: evidence for autocrine and paracrine roles.

9 July 2018

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Signal transduction by integrins: increased protein tyrosine phosphorylation caused by clustering of beta 1 integrins

9 July 2018

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pp125FAK a structurally distinctive protein-tyrosine kinase associated with focal adhesions

9 July 2018

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Tyrosine phosphorylation of paxillin and pp125FAK accompanies cell adhesion to extracellular matrix: a role in cytoskeletal assembly

9 July 2018

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Regulation of focal adhesion-associated protein tyrosine kinase by both cellular adhesion and oncogenic transformation

9 July 2018

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FAK overexpression upregulates cyclin D3 and enhances cell proliferation via the PKC and PI3-kinase-Akt pathways

9 July 2018

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Focal adhesion kinase and Src mediate integrin regulation of insulin receptor phosphorylation

27 September 2018

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Integrin signalling and tyrosine phosphorylation: just the FAKs?

27 September 2018

1 reference

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Cell adhesion and focal adhesion kinase regulate insulin receptor substrate-1 expression

27 September 2018

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12 December 2020

Impairment of mobility in endodermal cells by FAK deficiency

1 reference

12 December 2020

Stimulation of cell migration by overexpression of focal adhesion kinase and its association with Src and Fyn

1 reference

12 December 2020

Focal adhesion kinase in integrin-mediated signaling

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12 December 2020

Identifiers

DOI

10.1002/MC.20590

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6 August 2017

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6 August 2017

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