Targeted disruption of TGF-beta/Smad3 signaling modulates skin fibrosis in a mouse model of scleroderma (Q35102837)

6 August 2017

title

Targeted disruption of TGF-beta/Smad3 signaling modulates skin fibrosis in a mouse model of scleroderma (English)

1 reference

6 August 2017

1

Gabriella Lakos

1 reference

6 August 2017

Shinsuke Takagawa

2

1 reference

6 August 2017

Shu-Jen Chen

3

1 reference

6 August 2017

Ahalia M Ferreira

4

1 reference

6 August 2017

Gangwen Han

5

1 reference

6 August 2017

Koichi Masuda

6

1 reference

6 August 2017

Xiao-Jing Wang

7

1 reference

6 August 2017

Luisa A DiPietro

8

1 reference

6 August 2017

John Varga

9

1 reference

6 August 2017

language of work or name

English

0 references

publication date

1 July 2004

1 reference

The American Journal of Pathology

6 August 2017

published in

1 reference

6 August 2017

volume

165

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6 August 2017

issue

1

1 reference

6 August 2017

page(s)

203-217

1 reference

Amelioration of radiation-induced fibrosis: inhibition of transforming growth factor-beta signaling by halofuginone.

6 August 2017

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Interference with transforming growth factor-beta/ Smad3 signaling results in accelerated healing of wounds in previously irradiated skin

9 July 2018

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Targeted disruption of TGF-β1/Smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction

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9 July 2018

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Deficient Smad7 expression: a putative molecular defect in scleroderma

9 July 2018

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Mice lacking Smad3 are protected against cutaneous injury induced by ionizing radiation

9 July 2018

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9 July 2018

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9 July 2018

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9 July 2018

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Identification of novel TGF-beta /Smad gene targets in dermal fibroblasts using a combined cDNA microarray/promoter transactivation approach.

9 July 2018

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Lack of skin fibrosis in tight skin (TSK) mice with targeted mutation in the interleukin-4R alpha and transforming growth factor-beta genes.

9 July 2018

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Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation

9 July 2018

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Sp1 and Smad proteins cooperate to mediate transforming growth factor-beta 1-induced alpha 2(I) collagen expression in human glomerular mesangial cells

9 July 2018

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9 July 2018

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Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response

9 July 2018

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Overexpression of activin A in the skin of transgenic mice reveals new activities of activin in epidermal morphogenesis, dermal fibrosis and wound repair

9 July 2018

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Targeted disruption of Smad3 reveals an essential role in transforming growth factor beta-mediated signal transduction

9 July 2018

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Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta

9 July 2018

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Alternatively spliced variant of Smad2 lacking exon 3. Comparison with wild-type Smad2 and Smad3.

9 July 2018

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9 July 2018

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Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene

9 July 2018

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Smad-dependent transcriptional activation of human type VII collagen gene (COL7A1) promoter by transforming growth factor-beta

9 July 2018

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SMADs: mediators and regulators of TGF-beta signaling

9 July 2018

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9 July 2018

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Expression and function of heat shock protein 47: a collagen-specific molecular chaperone in the endoplasmic reticulum

9 July 2018

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Costimulation of fibroblast collagen and transforming growth factor beta1 gene expression by monocyte chemoattractant protein-1 via specific receptors

9 July 2018

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Myofibroblasts from scleroderma skin synthesize elevated levels of collagen and tissue inhibitor of metalloproteinase (TIMP-1) with two forms of TIMP-1.

9 July 2018

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Selective staining of human dermal collagen. II. The use of picrosirius red F3BA with polarization microscopy.

9 July 2018

1 reference

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Transforming growth factor beta (TGF beta) causes a persistent increase in steady-state amounts of type I and type III collagen and fibronectin mRNAs in normal human dermal fibroblasts

9 July 2018

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Transforming growth factor type beta induces monocyte chemotaxis and growth factor production

9 July 2018

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Autoinduction of transforming growth factor beta 1 is mediated by the AP-1 complex

9 July 2018

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Role of monocyte chemoattractant protein-1 and its receptor,CCR-2, in the pathogenesis of bleomycin-induced scleroderma

9 July 2018

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Distribution of phosphorylated Smad2 identifies target tissues of TGF beta ligands in mouse development

27 September 2018

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Mice lacking Smad3 are protected against streptozotocin-induced diabetic glomerulopathy

27 September 2018

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Identification of novel inhibitors of the transforming growth factor beta1 (TGF-beta1) type 1 receptor (ALK5).

27 September 2018

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Smad3 deficiency attenuates bleomycin-induced pulmonary fibrosis in mice

27 September 2018

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Evidence for increased pyridinoline concentration in fibrotic tissues in diffuse systemic sclerosis

27 September 2018

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Functional characterization of transforming growth factor beta signaling in Smad2- and Smad3-deficient fibroblasts

27 September 2018

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CTGF and SMADs, maintenance of scleroderma phenotype is independent of SMAD signaling

27 September 2018

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Bleomycin-induced cutaneous toxicity in the rat: analysis of histopathology and ultrastructure compared with progressive systemic sclerosis (scleroderma

27 September 2018

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Animal model of sclerotic skin. I: Local injections of bleomycin induce sclerotic skin mimicking scleroderma

7 January 2021

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Anti-sclerotic effect of transforming growth factor-beta antibody in a mouse model of bleomycin-induced scleroderma

7 January 2021

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Sustained activation of fibroblast transforming growth factor-beta/Smad signaling in a murine model of scleroderma

7 January 2021

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Determination of hydroxyproline in tissue collagen hydrolysate by derivatization and isocratic reversed-phase high-performance liquid chromatography

7 January 2021

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Expression and regulation of intracellular SMAD signaling in scleroderma skin fibroblasts

7 January 2021

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Selective Staining of Human Dermal Collagen

7 January 2021

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Role of apoptosis and transforming growth factor beta1 in fibroblast selection and activation in systemic sclerosis

7 January 2021

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Animal model of sclerotic skin. V: Increased expression of alpha-smooth muscle actin in fibroblastic cells in bleomycin-induced scleroderma

7 January 2021

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Stimulation of Type I Collagen Transcription in Human Skin Fibroblasts by TGF-β: Involvement of Smad 3

7 January 2021

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Latency-associated peptide prevents skin fibrosis in murine sclerodermatous graft-versus-host disease, a model for human scleroderma

7 January 2021

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Overhydroxylation of lysyl residues is the initial step for altered collagen cross-links and fibril architecture in fibrotic skin

7 January 2021

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Overexpression of monocyte chemoattractant protein 1 in systemic sclerosis: role of platelet-derived growth factor and effects on monocyte chemotaxis and collagen synthesis

7 January 2021

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Monocyte chemoattractant protein 3 as a mediator of fibrosis: Overexpression in systemic sclerosis and the type 1 tight-skin mouse

7 January 2021

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https://api.crossref.org/works/10.1016/S0002-9440(10)63289-0

Anti-TGF-beta treatment prevents skin and lung fibrosis in murine sclerodermatous graft-versus-host disease: a model for human scleroderma

7 January 2021

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15215176

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/S0002-9440(10)63289-0

1 reference

6 August 2017

1 reference

6 August 2017

1 reference